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Brain Stimulation for Schizophrenia

N/A
Recruiting
Led By Philip Gerretsen, MD, PhD
Research Sponsored by Centre for Addiction and Mental Health
Eligibility Criteria Checklist
Specific guidelines that determine who can or cannot participate in a clinical trial
Must have
DSM-V diagnosis of SCZ or schizoaffective disorder
Be older than 18 years old
Timeline
Screening 3 weeks
Treatment Varies
Follow Up during 3-month follow up phase
Awards & highlights

Study Summary

This trial will explore whether a non-invasive brain stimulation called transcranial direct current stimulation (tDCS) can help improve adherence to antipsychotic medication in people with schizophrenia.

Who is the study for?
This trial is for adults with schizophrenia or schizoaffective disorder who are on a stable medication regimen and can consent to participate. It's not for pregnant individuals, those with certain learning difficulties, severe thought disorders, recent substance dependence (except caffeine/nicotine), metal implants/pacemakers, acute suicidal/homicidal thoughts, or other major medical/neurological illnesses.Check my eligibility
What is being tested?
The study tests transcranial direct current stimulation (tDCS) as an additional treatment to help patients with schizophrenia stick to their antipsychotic medication schedule. Participants will receive either the active tDCS or a sham (fake) version in 20 sessions to compare effects on medication adherence.See study design
What are the potential side effects?
While tDCS is generally considered safe, potential side effects may include mild itching, tingling or discomfort at the electrode site during stimulation. There might also be fatigue or headache after the session but serious side effects are rare.

Eligibility Criteria

Inclusion Criteria

You may be eligible if you check “Yes” for the criteria below
Select...
I have been diagnosed with schizophrenia or schizoaffective disorder.

Timeline

Screening ~ 3 weeks
Treatment ~ Varies
Follow Up ~during 3-month follow up phase
This trial's timeline: 3 weeks for screening, Varies for treatment, and during 3-month follow up phase for reporting.

Treatment Details

Study Objectives

Outcome measures can provide a clearer picture of what you can expect from a treatment.
Primary outcome measures
Medication adherence - Clinician Rating
Medication adherence - Pill Count
Medication adherence - Plasma Monitoring
Secondary outcome measures
Insight into Psychosis

Trial Design

2Treatment groups
Experimental Treatment
Placebo Group
Group I: Active TDCSExperimental Treatment1 Intervention
In the active condition, a constant current of 2 mA intensity will be applied for 20 min to the parietal regions, using P3 as the cathode and P4 as the anode.
Group II: Sham TDCSPlacebo Group1 Intervention
In the sham condition, stimulation will be administered using the same parameters at the site of active treatment, but the current will be turned off after 30 seconds.

Find a Location

Who is running the clinical trial?

Centre for Addiction and Mental HealthLead Sponsor
356 Previous Clinical Trials
81,352 Total Patients Enrolled
58 Trials studying Schizophrenia
4,125 Patients Enrolled for Schizophrenia
Philip Gerretsen, MD, PhDPrincipal InvestigatorCentre for Addiction and Mental Health
5 Previous Clinical Trials
188 Total Patients Enrolled
4 Trials studying Schizophrenia
128 Patients Enrolled for Schizophrenia

Frequently Asked Questions

These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.

What is the quota of participants accepted to this research endeavor?

"Affirmative. According to the information hosted on clinicaltrials.gov, this experiment was first posted on August 15th 2019 and is currently looking for 106 volunteers from 1 trial site. The study's details were most recently updated in June 2nd 2022."

Answered by AI

Is there an ongoing recruitment process for this experiment?

"As documented on clinicaltrials.gov, this medical trial is in the process of recruiting participants. It was first published on August 15th 2019 and last modified on June 2nd 2022."

Answered by AI

Who else is applying?

What state do they live in?
Texas
How old are they?
18 - 65
What portion of applicants met pre-screening criteria?
Did not meet criteria
Recent research and studies
clinicaltrials.govStudy
The Effects of Non-invasive Brain Stimulation on Treatment Adherence in Schizophrenia
Philip Gerretsen 2019. "The Effects of Non-invasive Brain Stimulation on Treatment Adherence in Schizophrenia". ClinicalTrials.gov. https://clinicaltrials.gov/ct2/show/NCT04033679.
~13 spots leftby Dec 2024
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