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Oxytocin + Oxycodone for Pain
Study Summary
This trial will study whether taking oxytocin with oxycodone may reduce abuse liability and improve pain reduction.
Eligibility Criteria
Inclusion Criteria
You may be eligible if you check “Yes” for the criteria belowTimeline
Treatment Details
Study Objectives
Outcome measures can provide a clearer picture of what you can expect from a treatment.Trial Design
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Who is running the clinical trial?
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- I have not had chronic pain in the last 3 months.My heart's electrical activity is normal and my blood tests show no major health issues.You are not currently seeking treatment for drug abuse.You have a problem with using illegal drugs or are currently experiencing withdrawal symptoms from any abused drug (excluding nicotine and caffeine).I am not pregnant or nursing.Your weight cannot be too much lower or higher than what is considered healthy for your body size.You must tell us if you use opioids for non-medical reasons.You have a serious physical illness or mental health condition.
- Group 1: placebo+placebo
- Group 2: Oral oxycodone (2.5mg) + intranasal oxytocin (48 IU)
- Group 3: oxycodone (5mg) + intranasal oxytocin (48 IU)
- Group 4: Oral oxycodone (5mg) + intranasal placebo
- Group 5: oxytocin+placebo
- Group 6: Oral oxycodone (2.5mg) + intranasal placebo
- All Individual Drugs Already Approved - Therapies where all constituent drugs have already been approved are likely to have better-understood side effect profiles.
- Approved for 10 Other Conditions - This treatment demonstrated efficacy for 10 other conditions.
- Screening: It may take up to 3 Weeks to process to see if you qualify in this trial.
- Treatment: The duration you will receive the treatment varies.
- Follow Ups: You may be asked to continue sharing information regarding the trial for 6 Months after you stop receiving the treatment.
Frequently Asked Questions
Is there an age limit for participating in this experiment?
"This study has an age range criterion of 21 to 45 years old. Patients younger or older than this range will be ineligible for enrollment."
Is this trial looking to accept more participants at the present moment?
"At the moment, this medical investigation is searching for participants to join. Initially posted on December 1st 2022 and edited lastly on November 17th 2022, clinicaltrials.gov has documented these details."
Am I a suitable candidate to take part in this research endeavor?
"This medical experiment is enrolling 45 individuals aged 21 - 45 who currently experience acute pain. To qualify, participants must be proficient in English and report any recreational opioid use. Furthermore, they must also maintain a body mass index within 20% of their ideal weight, not have chronic pain (discomfort on most days during the past 3 months), possess systolic blood pressure less than or equal to 140 mmHg with diastolic blood pressure <= 90mmHg and heart rate lower than or equal to 90 beats per minute; additionally having a normal electrocardiogram readout as well as healthy clinical lab results are paramount for eligibility"
How many individuals may take part in this research endeavor?
"Affirmative. The information on clinicaltrials.gov attests that this research is currently recruiting participants - the initial post was made on December 1st 2022, and it has been recently revised as of November 17th 2022. 45 individuals must be recruited from a single site."
How is the combination of oxycodone and oxytocin typically employed therapeutically?
"Oxycodone+oxytocin is employed to treat inevitable abortion and additional conditions, like incomplete labor, uterine contraction, and miscarriage."
What precedent exists for the combination of oxycodone and oxytocin in scientific research?
"Currently, 77 oxycodone+oxytocin clinical trials are taking place with 15 in Phase 3. Omaha, Nebraska is the primary hub of these studies; however 124 medical sites host these trials across the country."
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