Oxytocin + Oxycodone for Pain
What You Need to Know Before You Apply
What is the purpose of this trial?
Some research suggests that administration of oxytocin with oxycodone may reduce its abuse liability and improve its ability to reduce pain. In a 6-session laboratory study, the investigators will be evaluating the effects of oxycodone and oxytocin (combined and separately, across sessions) on experimentally-induced pain, subjective effects, decision-making, and activation of different neural substrates.
Will I have to stop taking my current medications?
The trial information does not specify whether you need to stop taking your current medications. However, it does mention that participants should not have any significant physical diseases or major psychiatric disorders, which might imply some restrictions on medications. It's best to discuss your specific medications with the trial coordinators.
Is the combination of oxytocin and oxycodone generally safe for humans?
What makes the drug oxytocin + oxycodone unique for pain management?
This drug combination is unique because it combines oxycodone, a common opioid pain reliever, with oxytocin, a hormone that has potential analgesic (pain-relieving) properties and may offer pain relief with fewer side effects. Oxytocin's role in pain management is being explored for its non-addictive nature and ability to modulate pain through different mechanisms than traditional opioids.678910
What data supports the effectiveness of the drug combination of oxytocin and oxycodone for pain management?
Research shows that oxycodone, when combined with acetaminophen, is effective for managing moderate-to-severe pain due to their complementary actions, which may suggest potential benefits when combined with other agents like oxytocin. Additionally, oxycodone alone has been effective in reducing pain in various settings, including postoperative and cancer-related pain.211121314
Who Is on the Research Team?
Meredith S Berry, PhD
Principal Investigator
University of Florida
Are You a Good Fit for This Trial?
This trial is for English-speaking individuals who occasionally use opioids recreationally, have normal blood pressure and heart rate, a clean EKG, are within 20% of ideal body weight, and don't suffer from chronic pain. Pregnant or nursing women, those with significant diseases or metal implants that affect MRI safety, or people seeking drug abuse treatment cannot participate.Inclusion Criteria
Exclusion Criteria
Timeline for a Trial Participant
Screening
Participants are screened for eligibility to participate in the trial
Treatment
Participants receive oxycodone and oxytocin (combined and separately) across 6 sessions to evaluate effects on pain and abuse liability
Follow-up
Participants are monitored for safety and effectiveness after treatment
What Are the Treatments Tested in This Trial?
Interventions
- oxycodone
- oxytocin
oxycodone is already approved in United States, Canada, European Union for the following indications:
- Severe pain
- Chronic pain
- Severe pain
- Chronic pain
- Severe pain
- Chronic pain
Find a Clinic Near You
Who Is Running the Clinical Trial?
University of Florida
Lead Sponsor
National Institute on Drug Abuse (NIDA)
Collaborator