Exercise for Obesity
What You Need to Know Before You Apply
What is the purpose of this trial?
This trial explores how different types of exercise affect body fat and help control blood sugar and weight. Participants will join one of several exercise programs, ranging from high to moderate intensity, based on their health condition. The trial seeks individuals who are either healthy or have type 2 diabetes and have been overweight or obese, excluding those currently dieting or trying to lose weight.
As an unphased trial, this study provides a unique opportunity to contribute to understanding the impact of exercise on health.
Will I have to stop taking my current medications?
The trial excludes people using beta-blockers or thiazolidinediones, so you would need to stop these medications to participate. The protocol does not specify other medication restrictions.
What prior data suggests that this exercise intervention is safe?
Research has shown that high-intensity training can improve fitness and reduce body fat in adults with obesity. Although more demanding, it is generally safe and often yields good results without major issues.
Evidence supports the safety and effectiveness of moderate-intensity training. It helps reduce liver fat and manage weight in people who are overweight or obese. This type of exercise is easy to do regularly without causing harm.
Studies have demonstrated the safety of both high and moderate-intensity training. Participants in these studies did not report any significant negative effects. Therefore, both types of exercise are considered safe options for those looking to improve health and manage weight.12345Why are researchers excited about this trial?
Researchers are excited about these exercise interventions for obesity because they explore the potential of tailored exercise programs to improve health outcomes. Unlike conventional treatments for obesity, which often involve medication or surgery, these interventions focus on high and moderate intensity training tailored to different body types and health conditions. This trial offers a personalized approach, aiming to understand how specific exercise regimens can effectively manage obesity and related conditions like type 2 diabetes. By examining how varying exercise intensities impact different groups, the study seeks to offer insights into more sustainable and accessible obesity management strategies.
What evidence suggests that this trial's exercise interventions could be effective for obesity?
This trial will compare different exercise interventions for managing obesity. Participants will join various treatment arms, including high-intensity and moderate-intensity exercise programs. Studies have shown that high-intensity workouts effectively improve fitness and reduce body fat. Research indicates that high-intensity exercise benefits fat loss and metabolism. Meanwhile, moderate-intensity exercise also reduces body fat and waist size, especially with at least 150 minutes of aerobic exercise weekly. Both exercise types are beneficial, but high-intensity workouts might slightly better improve body composition, which is the balance of muscle and fat in the body.14678
Who Is on the Research Team?
Laurie J Goodyear, PhD
Principal Investigator
Joslin Diabetes Center
Are You a Good Fit for This Trial?
This trial is for adults aged 25-55 with varying body weights and conditions: healthy, overweight, obese, or with type 2 diabetes. Participants should have a BMI within certain ranges depending on their health status and controlled HbA1c levels. Those pregnant, on specific medications, with severe hypertension or other serious health issues are excluded.Inclusion Criteria
Exclusion Criteria
Timeline for a Trial Participant
Screening
Participants are screened for eligibility to participate in the trial
Treatment
Participants undergo a 10-week exercise program with varying intensity based on their group assignment
Follow-up
Participants are monitored for changes in adipose tissue characteristics and metabolic homeostasis after the exercise program
What Are the Treatments Tested in This Trial?
Interventions
- Exercise Intervention
Trial Overview
The study investigates how exercise affects white adipose tissue (body fat) in relation to sugar regulation and weight control. It aims to understand if regular physical activity can lead to beneficial changes in the body's handling of sugar among different groups of people.
How Is the Trial Designed?
4
Treatment groups
Experimental Treatment
Eligible subjects will undergo a 10-week moderate intensity exercise program.
Eligible subjects will undergo a 10-week moderate intensity exercise program.
Eligible subjects will undergo a 10-week moderate intensity exercise program.
Eligible subjects will undergo a 10-week high intensity exercise program
Find a Clinic Near You
Who Is Running the Clinical Trial?
Joslin Diabetes Center
Lead Sponsor
National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
Collaborator
Citations
High intensity training in obesity: a Meta‐analysis - PMC
Training at high intensity is superior to improve cardiopulmonary fitness and to reduce %body fat in adults with obesity compared to traditional exercise.
Outcomes from a 12-Month Intervention in Overweight Adults
HIIT showed no difference in weight or visceral fat compared to standard exercise after 12 months, but regular HIIT showed weight and fat reduction. HIIT was ...
Comparative effects of high-intensity interval training and ...
Overall, for college students living with obesity, both HIIT and MICT have shown positive effects. Among these, HIIT demonstrates greater ...
Effects of high intensity interval training and moderate ...
The objective of this meta-analysis is to evaluate and compare the effectiveness of HIIT and MICT on enjoyment and affective responses in overweight or obese ...
The Combined Effects of High-Intensity Interval Exercise ...
Almost all studies (93%) demonstrated effectiveness of high-intensity interval training of various protocols in reducing body fat, improving metabolic health ...
The effect of high-intensity interval training on health ...
The proportion of overweight and obese individuals in this demographic has skyrocketed, jumping from just 8% in 1990 to a staggering 20% in 2022 ...
Feasibility and efficacy of adding high-intensity interval ...
In Denmark, up to 16% of children and adolescents suffer from overweight or obesity [1]. Children and adolescents with obesity are at increased ...
NCT03361644 | The Role of High Intensity Interval Training ...
Inclusion Criteria: Age of 12 to 16 years with obesity (BMI ≥95% percentile for age and gender according to the CDC Growth Charts). Have ...
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