Prophylactic Antibiotics for Bladder Cancer
What You Need to Know Before You Apply
What is the purpose of this trial?
Using a randomized 2 arm design, this study is being conducted to test for non-inferiority of no prophylactic antibiotic therapy versus the prophylactic oral antibiotic, nitrofurantoin, through comparison of rates of postoperative urinary tract infections within the 90-day postoperative period in patients with muscle invasive bladder cancer who undergo radical cystectomy with urinary diversion.
Will I have to stop taking my current medications?
The trial information does not specify if you need to stop taking your current medications. However, if you are currently receiving antimicrobials for an active infection, you would not be eligible to participate.
Is nitrofurantoin safe for humans?
How does the drug nitrofurantoin differ from other treatments for bladder cancer?
Who Is on the Research Team?
Hamed Ahmadi, MD
Principal Investigator
University of Minnesota
Are You a Good Fit for This Trial?
This trial is for individuals with muscle invasive bladder cancer who are undergoing radical cystectomy and urinary diversion. Specific eligibility details aren't provided, but typically participants must meet certain health criteria to join.Inclusion Criteria
Exclusion Criteria
Timeline for a Trial Participant
Screening
Participants are screened for eligibility to participate in the trial
Treatment
Participants undergo radical cystectomy with urinary diversion and are randomized to receive either no prophylactic antibiotics or prophylactic oral antibiotic, nitrofurantoin, postoperatively
Follow-up
Participants are monitored for postoperative urinary tract infections and other outcomes
What Are the Treatments Tested in This Trial?
Interventions
- Nitrofurantoin
Find a Clinic Near You
Who Is Running the Clinical Trial?
University of Minnesota
Lead Sponsor