Bryophyllum Pinnatum Tea for Kidney Stones

Age: 18+

Sex: Any

Trial Phase: Phase < 1

Sponsor: Indra Gupta

Must not be taking: Stone-preventing medications

Disqualifiers: Pregnancy, Cancer, Gluten intolerance, others

No Placebo Group All trial participants will receive the active study treatment (no placebo)

Compensation: Varies

Number of Visits: 2

Duration: 11 days

25 Participants Needed

Trial Summary

What is the purpose of this trial?

The aim of this randomized placebo-controlled double-blind crossover clinical trial is to test the ability of a traditional tea made from the leaf of the Bryophyllum pinnatum (B. pinnatum) plant in decreasing urinary calcium content in patients with recurrent calcium-based kidney stones.

Research Team

Indra Gupta, MD

Principal Investigator

Research Institute at the McGill University Health Centre

Eligibility Criteria

This trial is for people who frequently get calcium-based kidney stones. Participants should be adults with a history of these stones and willing to drink assigned teas regularly. Specific health conditions or medications that could interfere with the study are reasons for exclusion.

Inclusion Criteria

I have had a kidney stone or high calcium in my urine in the last 3 years.

Had an ultrasound or CT imaging within the previous 6 months showing no evidence of current obstructive kidney stone

Agrees to maintain current lifestyle habits and avoid taking new supplements during the study period

Exclusion Criteria

I have a condition like hyperparathyroidism or IBD that causes calcium stones.

Patients who are pregnant or nursing or who are trying to become pregnant

I am currently taking B. pinnatum or products with polyphenols.

Timeline

Screening

Participants are screened for eligibility to participate in the trial

2-4 weeks

Treatment

Participants receive either B. pinnatum tea or placebo and undergo urine and blood analysis

11 days

2 visits (in-person)

Follow-up

Participants are monitored for safety and effectiveness after treatment

4 weeks

Treatment Details

Interventions

• Bryophyllum Pinnatum Tea

Trial Overview The study tests if Bryophyllum pinnatum tea can reduce urinary calcium in recurrent kidney stone patients, compared to a placebo tea. It's randomized and double-blind, meaning neither researchers nor participants know who gets the real or placebo tea until after results.

Participant Groups

Group I: Placebo - First Experimental Treatment 2 Interventions

Participants in this arm will receive 250 mL of sweetened placebo tea on day 1 and then on day 2, they will submit urine and blood for analysis for biochemistry. On day 10, participants will receive 250 mL of sweetened B. pinnatum tea. On day 11, they will again submit a 24-hour urine collection and a blood sample for analysis.

Group II: B. pinnatum tea - First Experimental Treatment 2 Interventions

Participants in this arm will receive 250 mL of sweetened B. pinnatum tea on day 1 and then on day 2, they will submit urine and blood for analysis for biochemistry. On day 10, participants will receive 250 mL of sweetened placebo tea. On day 11, they will again submit a 24-hour urine collection and a blood sample for analysis.

Who Is Running the Clinical Trial?

Indra Gupta

Lead Sponsor