Dapansutrile for Heart Attack Recovery
What You Need to Know Before You Apply
What is the purpose of this trial?
This trial tests a pill called dapansutrile on heart attack patients who received prompt care. The pill aims to reduce inflammation, which can help lower harmful artery plaque and improve heart function.
Will I have to stop taking my current medications?
The trial information does not specify if you need to stop taking your current medications. However, if you are using immunosuppressive medications, you may not be eligible to participate.
How is the drug Dapansutrile unique for heart attack recovery?
Dapansutrile is unique because it targets inflammation, which is a key factor in heart attack recovery, by inhibiting a specific protein involved in the inflammatory process. This approach is different from traditional treatments that primarily focus on improving blood flow or reducing heart workload.12345
Are You a Good Fit for This Trial?
This trial is for individuals who have had a type I heart attack and received reperfusion therapy within the last 48 hours. They must have certain levels of artery plaque or thickness to join. People with severe kidney issues, recent strokes, allergies to specific agents, pregnancy, life-threatening complications from their heart attack, certain infections or cancers can't participate.Inclusion Criteria
Exclusion Criteria
Timeline for a Trial Participant
Screening
Participants are screened for eligibility to participate in the trial
Treatment
Participants are randomized to receive either placebo or the oral inflammasome (NLRP3) inhibitor dapansutrile
Follow-up
Participants are monitored for safety and effectiveness after treatment
What Are the Treatments Tested in This Trial?
Interventions
- Dapansutrile
- Placebo
Find a Clinic Near You
Who Is Running the Clinical Trial?
University of Virginia
Lead Sponsor