Metal Detoxification for Acute Myeloid Leukemia
Trial Summary
What is the purpose of this trial?
The goal of this clinical research study is to learn if metal detoxification (with calcium disodium edetate \[Ca-EDTA\] and dimercaptosuccinic acid \[DMSA\]) during standard therapy can help improve outcomes in patients with intermediate-risk, high-risk, or secondary AML compared to standard therapy alone. Researchers think lowering the level of metals found in the blood/bone marrow may help to control the disease and/or improve the response to chemotherapy.
Do I have to stop taking my current medications for this trial?
The trial protocol does not specify whether you need to stop taking your current medications. It's best to discuss your specific situation with the study team or your doctor.
Is the metal detoxification treatment generally safe for humans?
How does the drug Ca-EDTA, DMSA differ from other treatments for acute myeloid leukemia?
Ca-EDTA and DMSA are unique in treating acute myeloid leukemia because they focus on detoxifying heavy metals, which may impact survival rates, unlike traditional treatments that target cancer cells directly. This approach is based on research suggesting that metal levels in the body can influence leukemia outcomes.23467
Research Team
Maro Ohanian, DO
Principal Investigator
M.D. Anderson Cancer Center
Eligibility Criteria
This trial is for individuals with intermediate-risk, high-risk, or secondary Acute Myeloid Leukemia (AML). Participants should be undergoing standard therapy for AML. Specific inclusion and exclusion criteria details are not provided but would typically relate to health status and prior treatments.Inclusion Criteria
Exclusion Criteria
Timeline
Screening
Participants are screened for eligibility to participate in the trial
Treatment
Participants receive metal detoxification with DMSA and Ca-EDTA during standard AML therapy
Follow-up
Participants are monitored for safety and effectiveness after treatment
Treatment Details
Interventions
- Ca-EDTA
- DMSA
Find a Clinic Near You
Who Is Running the Clinical Trial?
M.D. Anderson Cancer Center
Lead Sponsor