90 Participants Needed

Optical Imaging for Gum Disease

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WM
SY
Overseen BySeok-Hyun Yun, PhD
Age: 18+
Sex: Any
Trial Phase: Academic
Sponsor: Massachusetts General Hospital
No Placebo GroupAll trial participants will receive the active study treatment (no placebo)

What You Need to Know Before You Apply

What is the purpose of this trial?

The overall goal of this study is to develop OCT Vibrography (aka OCT elastography) as a novel tool for measuring biomechanical properties of human tissues in vivo.

Will I have to stop taking my current medications?

The trial information does not specify whether you need to stop taking your current medications.

Is optical imaging for gum disease safe for humans?

Optical imaging techniques like Optical Coherence Tomography (OCT) are generally considered safe for humans as they are non-invasive and do not use harmful radiation, making them suitable for imaging oral tissues.12345

How does the optical imaging treatment for gum disease differ from other treatments?

Optical imaging for gum disease uses optical coherence tomography (OCT), a noninvasive method that provides detailed images of oral tissues without the need for X-rays or biopsies. This treatment is unique because it allows for real-time monitoring and early detection of periodontal disease by capturing high-resolution images of both hard and soft tissues in the mouth.25678

What data supports the effectiveness of the treatment Optical Imaging for Gum Disease?

Research shows that Optical Coherence Tomography (OCT) can effectively image and monitor gum disease by providing detailed images of the tissues in the mouth. It has been used to track improvements in gum health after treatment, making it a useful tool for diagnosing and following up on periodontal disease.258910

Who Is on the Research Team?

SY

Seok-Hyun Yun, PhD

Principal Investigator

Massachusetts General Hospital

Are You a Good Fit for This Trial?

This trial is for people aged 18-75 with healthy eyes. It's designed to test a new imaging technique on various tissues, including gums, skin, and corneas.

Inclusion Criteria

I am between 18 and 75 years old with healthy skin.
I am 18-40 years old with mild or moderate keratoconus.

Exclusion Criteria

I have had eye diseases or surgeries in the past.
I have diabetes or a family history of glaucoma.
Group 1: Subjects allergic to anesthetic eyedrop, especially proparacaine
See 6 more

Timeline for a Trial Participant

Screening

Participants are screened for eligibility to participate in the trial

2-4 weeks

Imaging

Optical imaging of the cornea, skin, and gingiva in healthy subjects and cornea in keratoconus subjects

1 year

Follow-up

Participants are monitored for safety and effectiveness after imaging procedures

4 weeks

What Are the Treatments Tested in This Trial?

Interventions

  • Optical imaging of the tissues
Trial Overview The study is testing OCT Vibrography (OCT elastography), an optical imaging method that measures how stiff or elastic human tissues are without needing surgery.
How Is the Trial Designed?
4Treatment groups
Experimental Treatment
Group I: Keratoconus corneaExperimental Treatment1 Intervention
Group II: Healthy skinExperimental Treatment1 Intervention
Group III: Healthy gingivaExperimental Treatment1 Intervention
Group IV: Healthy corneaExperimental Treatment1 Intervention

Find a Clinic Near You

Who Is Running the Clinical Trial?

Massachusetts General Hospital

Lead Sponsor

Trials
3,066
Recruited
13,430,000+

Massachusetts Eye and Ear Infirmary

Collaborator

Trials
115
Recruited
15,000+

Published Research Related to This Trial

Optical coherence tomography (OCT) has been successfully used to visualize periodontal structures and assess treatment outcomes in 14 patients with periodontal disease, demonstrating its potential as a noninvasive tool for dental practice.
The study showed that OCT can effectively identify improvements in periodontal health, such as reductions in gingival thickness and biofilm, over a follow-up period of up to 90 days, indicating its usefulness in monitoring treatment progress.
Optical coherence tomography follow-up of patients treated from periodontal disease.Fernandes, LO., Mota, CCBO., Oliveira, HO., et al.[2020]
Optical coherence tomography (OCT) effectively differentiates between various human oral tissues, such as enamel, cortical bone, trabecular bone, and fatty tissue, based on qualitative and quantitative analyses.
The study found that OCT provided comparable information to cone beam computed tomography regarding tissue properties, indicating its potential as a reliable imaging technique for assessing hard and soft tissues in oral applications.
Tissue characterization using optical coherence tomography and cone beam computed tomography: a comparative pilot study.Mahdian, M., Salehi, HS., Lurie, AG., et al.[2017]
A new optical coherence tomography (OCT) system has been developed that can produce high-resolution images of both hard and soft tissues in the oral cavity, specifically demonstrating its capability in imaging porcine periodontal tissues.
This is the first time OCT has been applied to biologic hard tissue imaging, suggesting it could be a valuable tool for diagnosing periodontal diseases by clearly visualizing critical interfaces like enamel-cementum and gingiva-tooth.
Imaging of hard- and soft-tissue structure in the oral cavity by optical coherence tomography.Colston, BW., Everett, MJ., Da Silva, LB., et al.[2022]

Citations

Optical coherence tomography follow-up of patients treated from periodontal disease. [2020]
Tissue characterization using optical coherence tomography and cone beam computed tomography: a comparative pilot study. [2017]
Imaging of hard- and soft-tissue structure in the oral cavity by optical coherence tomography. [2022]
Observation and determination of periodontal tissue profile using optical coherence tomography. [2018]
Optical coherence tomography diagnostic imaging. [2008]
Structural validation of oral mucosal tissue using optical coherence tomography. [2021]
In vivo diagnosis of oral dysplasia and malignancy using optical coherence tomography: preliminary studies in 50 patients. [2021]
In Vivo Endoscopic Optical Coherence Tomography of the Healthy Human Oral Mucosa: Qualitative and Quantitative Image Analysis. [2020]
The Use of Optical Coherence Tomography in Dental Diagnostics: A State-of-the-Art Review. [2023]
Dental optical coherence tomography. [2021]
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