Propranolol for Misophonia
What You Need to Know Before You Apply
What is the purpose of this trial?
This trial tests whether a single 20 mg dose of propranolol, a beta-blocker, can temporarily ease the emotional and physical symptoms of misophonia, a condition where certain sounds trigger intense emotional reactions. Researchers aim to identify who might respond best to this treatment and assess the safety of propranolol for those with misophonia. Participants should have significant symptoms, such as strong reactions to specific sounds, and be able to visit Littleton, CO, for the study. As an Early Phase 1 trial, this research explores how propranolol affects individuals with misophonia, offering participants a chance to contribute to groundbreaking insights into potential treatments.
Is there any evidence suggesting that propranolol is likely to be safe for humans?
Research has shown that propranolol has been used safely in various situations. The FDA has approved propranolol for treating high blood pressure and anxiety, indicating its well-established safety. Other studies have used propranolol in doses higher than the 20 mg being tested for misophonia, with some patients experiencing symptom relief and no serious side effects.
For instance, one case study found that a 60 mg dose eliminated misophonia symptoms without major issues. Another report noted significant symptom improvement in a patient taking propranolol, again without significant side effects.
This trial is in an early phase, designed to test both the effectiveness and safety of a single 20 mg dose of propranolol for misophonia. Researchers are still assessing how well propranolol is tolerated for this specific use. However, its previous use in other conditions provides some reassurance about its safety.12345Why do researchers think this study treatment might be promising for misophonia?
Propranolol is unique because it targets misophonia by potentially dampening the fight-or-flight response associated with sound triggers. While most treatments for misophonia focus on cognitive and behavioral therapies, propranolol acts as a beta-blocker, which may reduce the physical symptoms of anxiety triggered by certain sounds. Researchers are excited about propranolol because it offers a pharmacological approach that could provide quicker symptom relief compared to the standard non-drug therapies.
What evidence suggests that propranolol might be an effective treatment for misophonia?
Research has shown that propranolol, a beta-blocker, can reduce emotional and physical reactions in people with misophonia. One study found that propranolol stopped both emotional and physical responses to triggers, such as certain sounds or sights. Participants in that study had lower scores on the Amsterdam Misophonia Scale, which measures the severity of misophonia symptoms. The benefits were modest but persisted for a year, suggesting both short- and long-term advantages. In this trial, some participants will receive a one-time dose of 20 mg propranolol, which may work by calming the body's stress response, potentially lessening misophonia symptoms.1236
Are You a Good Fit for This Trial?
This trial is for individuals who experience strong negative reactions to specific sounds, a condition known as misophonia. Participants should be able to take a one-time dose of propranolol. Details on eligibility criteria are not fully provided.Inclusion Criteria
Timeline for a Trial Participant
Screening
Participants are screened for eligibility to participate in the trial
Treatment
Participants receive a one-time dose of 20 mg oral propranolol or placebo
Follow-up
Participants are monitored for safety and effectiveness after treatment
What Are the Treatments Tested in This Trial?
Interventions
- Propranolol
Find a Clinic Near You
Who Is Running the Clinical Trial?
Bloom Mental Health, LLC
Lead Sponsor