Propranolol for Misophonia

Overseen By Bloom Mental Health Clinic

Age: 18+

Sex: Any

Trial Phase: Phase < 1

Sponsor: Bloom Mental Health, LLC

Must not be taking: Beta blockers, Alpha blockers

Disqualifiers: Cardiovascular disease, Asthma, Diabetes, Pregnancy, others

Compensation: Varies

Number of Visits: 1

Duration: Single session

20 Participants Needed

What You Need to Know Before You Apply

What is the purpose of this trial?

This trial tests whether a single 20 mg dose of propranolol, a beta-blocker, can temporarily ease the emotional and physical symptoms of misophonia, a condition where certain sounds trigger intense emotional reactions. Researchers aim to identify who might respond best to this treatment and assess the safety of propranolol for those with misophonia. Participants should have significant symptoms, such as strong reactions to specific sounds, and be able to visit Littleton, CO, for the study. As an Early Phase 1 trial, this research explores how propranolol affects individuals with misophonia, offering participants a chance to contribute to groundbreaking insights into potential treatments.

Do I need to stop taking my current medications to join the trial?

The trial does not specify if you need to stop all current medications, but you cannot participate if you are taking propranolol or other medications that could interfere with propranolol, like other beta blockers or certain blood pressure medications. It's best to discuss your current medications with the study clinician to see if they might interfere.

Is there any evidence suggesting that propranolol is likely to be safe for humans?

Research has shown that propranolol has been used safely in various situations. The FDA has approved propranolol for treating high blood pressure and anxiety, indicating its well-established safety. Other studies have used propranolol in doses higher than the 20 mg being tested for misophonia, with some patients experiencing symptom relief and no serious side effects.

For instance, one case study found that a 60 mg dose eliminated misophonia symptoms without major issues. Another report noted significant symptom improvement in a patient taking propranolol, again without significant side effects.

This trial is in an early phase, designed to test both the effectiveness and safety of a single 20 mg dose of propranolol for misophonia. Researchers are still assessing how well propranolol is tolerated for this specific use. However, its previous use in other conditions provides some reassurance about its safety. ^{1 2 3 4 5}

Why do researchers think this study treatment might be promising for misophonia?

Propranolol is unique because it targets misophonia by potentially dampening the fight-or-flight response associated with sound triggers. While most treatments for misophonia focus on cognitive and behavioral therapies, propranolol acts as a beta-blocker, which may reduce the physical symptoms of anxiety triggered by certain sounds. Researchers are excited about propranolol because it offers a pharmacological approach that could provide quicker symptom relief compared to the standard non-drug therapies.

What evidence suggests that propranolol might be an effective treatment for misophonia?

Research has shown that propranolol, a beta-blocker, can reduce emotional and physical reactions in people with misophonia. One study found that propranolol stopped both emotional and physical responses to triggers, such as certain sounds or sights. Participants in that study had lower scores on the Amsterdam Misophonia Scale, which measures the severity of misophonia symptoms. The benefits were modest but persisted for a year, suggesting both short- and long-term advantages. In this trial, some participants will receive a one-time dose of 20 mg propranolol, which may work by calming the body's stress response, potentially lessening misophonia symptoms. ^{1 2 3 6}

Are You a Good Fit for This Trial?

This trial is for individuals who experience strong negative reactions to specific sounds, a condition known as misophonia. Participants should be able to take a one-time dose of propranolol. Details on eligibility criteria are not fully provided.

Inclusion Criteria

* Age 18-65.

* Able to complete study visit(s) in Littleton, CO.

* Able to give informed consent.

Timeline for a Trial Participant

Screening

Participants are screened for eligibility to participate in the trial

1-2 weeks

Treatment

Participants receive a one-time dose of 20 mg oral propranolol or placebo

Single session

1 visit (in-person)

Follow-up

Participants are monitored for safety and effectiveness after treatment

1 week

What Are the Treatments Tested in This Trial?

Interventions

• Propranolol

Trial Overview

The study is testing if a single dose of 20 mg oral propranolol can help with the emotional and physical symptoms caused by misophonia compared to a placebo. It also aims to identify factors predicting who might benefit from this treatment.

How Is the Trial Designed?

Group I: Propranolol Pill Experimental Treatment 1 Intervention

10 participants will take one-time dose of 20 mg propranolol pill

Group II: Placebo Pill Placebo Group 1 Intervention

10 participants will take be given a matching one-time dose of placebo

Who Is Running the Clinical Trial?

Bloom Mental Health, LLC

Lead Sponsor

Citations

1.

pubmed.ncbi.nlm.nih.gov

pubmed.ncbi.nlm.nih.gov/35029865/

β-Blockers for the Treatment of Misophonia and Misokinesia

Propranolol eliminated the emotional and physiological effects of both the auditory and visual triggers, with an Amsterdam Misophonia Scale score reduction ...

2.

clinicaltrials.gov

clinicaltrials.gov/study/NCT07271485

Study Details | NCT07271485 | Propranolol for Misophonia

The primary goal of this study is to investigate whether a one-time dose of 20 mg oral propranolol can temporarily reduce the adverse ...

3.

withpower.com

withpower.com/trial/early-phase-1-misophonia-5-2023-22686

Behavioral + Propranolol for Misophonia (Miso Prop Trial)

Research has shown that propranolol, a beta-blocker, can help reduce the emotional and physical reactions linked to misophonia. One case study demonstrated ...

4.

pmc.ncbi.nlm.nih.gov

pmc.ncbi.nlm.nih.gov/articles/PMC10276561/

A systematic review of treatments for misophonia - PMC

Effects were modest and maintained at 1-year follow-up, suggesting short and long-term benefit for misophonia symptoms. The same research group previously ...

5.

journals.lww.com

journals.lww.com/aips/fulltext/9900/quieting_the_triggers__exploring_therapeutic.139.aspx

Exploring Therapeutic Avenues for Misophonia

One patient with comorbid misophonia and misokinesia experienced a reduction in A-MISO-S scores from 15 to 2 after propranolol use, and further ...

6.

researchgate.net

researchgate.net/publication/357855233_b-Blockers_for_the_Treatment_of_Misophonia_and_Misokinesia

β-Blockers for the Treatment of Misophonia and Misokinesia

A moderate dose (60 mg) of propranolol completely eliminated multiple auditory and visual trigger symptoms related to other people eating. His ...