THC for Cannabis Use
(RiDE-2 Trial)
Trial Summary
Will I have to stop taking my current medications?
Yes, you will need to stop taking any medication that could interact with a single dose of Δ9-THC.
What data supports the effectiveness of the drug THC for cannabis use?
THC, a major component of cannabis, is used in FDA-approved drugs like nabiximols to help with pain and muscle stiffness in multiple sclerosis, and dronabinol for nausea in cancer patients and appetite loss in AIDS patients. This suggests THC can have therapeutic effects, although its use is limited by its mind-altering properties.12345
Is THC generally safe for human use?
How is the drug THC unique for treating cannabis use?
THC is unique because it is the main psychoactive component of cannabis and is being studied for its potential to help manage cannabis use itself, which is different from other treatments that might not directly involve cannabinoids. This approach leverages THC's interaction with the body's cannabinoid receptors, which is not a common mechanism in other treatments for cannabis use.1112131415
What is the purpose of this trial?
The purpose of this study is to better understand how people's mood, behavior, and brains respond to different recreational drugs. We are also trying to understand why some people may feel differently or their brain may respond differently than other people after taking the same recreational drug.
Eligibility Criteria
This trial is for healthy individuals interested in how recreational drugs like cannabis affect mood, behavior, and brain response. Participants should not have a history of prescription drug abuse or substance use disorders.Inclusion Criteria
Exclusion Criteria
Timeline
Screening
Participants are screened for eligibility to participate in the trial
Treatment
Participants receive THC or placebo during the first or second laboratory visit, with fMRI scanning to assess mood, behavior, and brain response
Follow-up
Participants are monitored for safety and effectiveness after treatment, with assessments of substance use and CUD/SUD symptoms
Treatment Details
Interventions
- THC
Find a Clinic Near You
Who Is Running the Clinical Trial?
University of Illinois at Chicago
Lead Sponsor