EEG Characteristics in ECT
Age: 18+
Sex: Any
Trial Phase: Phase < 1
Sponsor: University of New Mexico
No Placebo GroupAll trial participants will receive the active study treatment (no placebo)
Trial Summary
What is the purpose of this trial?
This trial is testing a treatment for depression using electric shocks to the brain while patients are asleep with either ketamine or methohexital. The goal is to see how slow brain waves change during the treatment and if these changes can show how well the treatment is working. Ketamine has long been used as an alternative anesthetic for ECT and appears to initially enhance the benefits of ECT.
Eligibility Criteria
Inclusion Criteria
Structured Clinical Interview for DSM-5 will confirm diagnosis of MDD or BPD-depressed (with or without psychotic features
The clinical indications for ECT including treatment resistance or a need for a rapid and definitive response;
Hamilton Depression Rating Scale 24-item (HDRS-24) > 21;
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Treatment Details
Interventions
- Ketamine
- Methohexital
Participant Groups
2Treatment groups
Experimental Treatment
Active Control
Group I: KetamineExperimental Treatment1 Intervention
Standard of care anesthesia that suppresses slow wave characteristics
Group II: MethohexitalActive Control1 Intervention
Standard of care anesthesia that does not affect slow wave characteristics
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Who Is Running the Clinical Trial?
University of New Mexico
Lead Sponsor
Trials
393
Recruited
3,526,000+
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