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Zinc Oxide vs. Petrolatum for Scarring

Phase < 1
Recruiting
Led By Lina Husienzad, MD
Research Sponsored by Lina Husienzad
Eligibility Criteria Checklist
Specific guidelines that determine who can or cannot participate in a clinical trial
Must have
End to end symmetry (surgical site is not grossly asymmetric from end to end)
≥ 18 years of age
Timeline
Screening 3 weeks
Treatment Varies
Follow Up six months post-operative follow-up
Awards & highlights

Study Summary

This trial is testing whether zinc oxide or petrolatum is more effective in healing scars. Patients will apply either zinc oxide or petrolatum to one half of their scar daily for a month and keep a log of their activities. They will be seen at 1 week, 4 weeks, 8 weeks, and 6 months post-operatively for photographic scar assessment and to complete the patient portion of the Patient and Observer Scar Assessment Scale. Trained observers will score the observer portion of the scale.

Who is the study for?
This trial is for adults who've had routine skin surgery with a straight-line scar at least 4.5cm long on non-scalp areas. The surgical site must be symmetrical and not visibly infected. People under 18 or those allergic to topical zinc oxide, as well as those with grossly infected scars or visibly asymmetric scars, cannot participate.Check my eligibility
What is being tested?
The study compares the effects of zinc oxide ointment versus petrolatum (a moisturizing agent) on post-surgical scarring. Participants will apply these treatments to different halves of their scar daily for a month and attend follow-up visits for photographic assessments and scoring using the Patient and Observer Scar Assessment Scale.See study design
What are the potential side effects?
Potential side effects may include skin irritation or an allergic reaction where the ointments are applied, especially in individuals sensitive to ingredients in zinc oxide.

Eligibility Criteria

Inclusion Criteria

You may be eligible if you check “Yes” for the criteria below
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My surgical site looks the same on both ends.
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I am 18 years old or older.
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My surgery scar is at least 4.5 cm long.
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My treatment site does not show signs of infection.

Timeline

Screening ~ 3 weeks
Treatment ~ Varies
Follow Up ~1 week, 4 weeks, 8 weeks, six months post-operatively
This trial's timeline: 3 weeks for screening, Varies for treatment, and 1 week, 4 weeks, 8 weeks, six months post-operatively for reporting.

Treatment Details

Study Objectives

Outcome measures can provide a clearer picture of what you can expect from a treatment.
Primary outcome measures
Change in % epidermal linear seal between weeks 1 and 4 post-operative
POSAS (patient and observer scar assessment score)
POSAS (patient and observer scar assessment score) change between 8 weeks and six months
+1 more
Secondary outcome measures
Communicable Diseases

Trial Design

1Treatment groups
Experimental Treatment
Group I: Single arm - split scar studyExperimental Treatment1 Intervention
Surgical closures, at least 4.5cm in length, will be split and zinc oxide ointment applied to half and petrolatum ointment to the other half

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Who is running the clinical trial?

Lina HusienzadLead Sponsor
Lauren CrowLead Sponsor
Lina Husienzad, MDPrincipal InvestigatorResident Physician, PGY-3

Frequently Asked Questions

These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.

Are there existing surveys that attest to the efficacy of this treatment?

"At this time, 8 studies on the efficacy of this treatment are underway. Of these, 0 have progressed to Phase 3 clinical trials. Most research centres are situated in Boston but there are 11 locations overall hosting investigations for this medication."

Answered by AI

Are there any available openings for participants in this experiment?

"Affirmative. According to clinicaltrials.gov, the trial is currently accepting new participants and was initially posted on September 1st 2021. The study requires 30 enrollees from a single medical centre as of April 14th 2022."

Answered by AI

What is the conventional application of this remedy?

"Generally, this medication is applied to sunburns. However, additional applications may involve treating dermabrasion and chafing of the skin."

Answered by AI

How many individuals are receiving the benefits of this trial's protocol?

"Affirmative. The information furnished on clinicaltrials.gov confirms that this research, which commenced in September 2021, is currently seeking participants. 30 individuals are being admitted at a single site for the duration of the trial."

Answered by AI
~5 spots leftby Sep 2024