AAA Group (Aim 3A) for Abdominal Aortic Aneurysm

Washington University School of Medicine, Saint Louis, MO
Abdominal Aortic Aneurysm+1 More ConditionsAAA Group (Aim 3A) - DiagnosticTest
Eligibility
40 - 80
All Sexes
What conditions do you have?
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Study Summary

This trial is testing a new approach for the diagnosis and targeted therapy of abdominal aortic aneurysm (AAA), a degenerative vascular disease which is typically asymptomatic until rupture, resulting in high mortality.

Eligible Conditions
  • Abdominal Aortic Aneurysm
  • Non-AAA (No Abdominal Aortic Aneurysm)

Treatment Effectiveness

Phase-Based Effectiveness

1 of 3
Phase < 1

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Study Objectives

4 Primary · 0 Secondary · Reporting Duration: 4 years

4 years
Assess imaging reproducibility of 64Cu-DOTA-ECL1i PET/CT in non-surgical AAA patients.
Assess the 64Cu-DOTA-ECL1i imaging characteristics in AAA patients undergoing open repair and non-AAA volunteers to determine the relationship between tracer uptake and molecular characterization of prospectively collected AAA tissues.
Determine the binding characteristics of 64Cu-DOTA-ECL1i in ex vivo human AAA specimens and correlate with associated histopathological features
Determine the relationship between 64Cu-DOTA-ECL1i binding, regional CCR2 gene expression, cytokine profiles and local matrix metalloproteinase (MMP) activity.

Trial Safety

Phase-Based Safety

1 of 3

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Awards & Highlights

No Placebo Group
All patients enrolled in this trial will receive the new treatment.

Trial Design

3 Treatment Groups

AAA Group (Aim 3B-Reproducibility)
1 of 3
Non-AAA Group
1 of 3
AAA Group (Aim 3A)
1 of 3

Experimental Treatment

50 Total Participants · 3 Treatment Groups

Primary Treatment: AAA Group (Aim 3A) · No Placebo Group · Phase < 1

AAA Group (Aim 3B-Reproducibility)
DiagnosticTest
Experimental Group · 1 Intervention: AAA Group (Aim 3B-Reproducibility) · Intervention Types: DiagnosticTest
Non-AAA Group
DiagnosticTest
Experimental Group · 1 Intervention: Non-AAA Group · Intervention Types: DiagnosticTest
AAA Group (Aim 3A)
DiagnosticTest
Experimental Group · 1 Intervention: AAA Group (Aim 3A) · Intervention Types: DiagnosticTest

Trial Logistics

Trial Timeline

Screening: ~3 weeks
Treatment: Varies
Reporting: 4 years

Who is running the clinical trial?

Washington University School of MedicineLead Sponsor
1,846 Previous Clinical Trials
2,280,523 Total Patients Enrolled
Mohamed M. Zayed, MDPrincipal InvestigatorWashington University of Medicine
1 Previous Clinical Trials
1 Total Patients Enrolled

Eligibility Criteria

Age 40 - 80 · All Participants · 1 Total Inclusion Criteria

Mark “Yes” if the following statements are true for you:
Whether or not you smoke cigarettes does not affect your eligibility.
References

Frequently Asked Questions

Is this research accommodating participants who are older than 25 years of age?

"As per the study's eligibility requirements, applicants must be between 40 and 80 years of age." - Anonymous Online Contributor

Unverified Answer

What is the cap for participation in this experimental undertaking?

"Affirmative, the information on clinicaltrials.gov corroborates that this trial is currently enrolling participants. It was first made visible to the public on February 17th 2021 and its last update came July 11th 2022. A total of 50 volunteers are sought from a single research site." - Anonymous Online Contributor

Unverified Answer

Are there still opportunities to participate in this experiment?

"Affirmative. The information located on clinicaltrials.gov implies that this study is actively seeking participants with the first posting occurring February 17th 2021 and the most recent update being July 11th 2022. 50 patients are needed from 1 centre." - Anonymous Online Contributor

Unverified Answer

May I submit my candidacy for this clinical experiment?

"This clinical trial seeks fifty participants between 40 and 80 years of age who have aneurysm. Additional requirements include being above the age of forty, having or not having active tobacco use, patients with known AAAs by CT angiogram (men ≥ 5.5 cm, women ≥ 5.0cm), exhibiting willingness to follow protocol instructions for study procedures, as well as non-AAA volunteers that can provide a documented absence of AAA via exam and recent screening ultrasound (US)." - Anonymous Online Contributor

Unverified Answer
Please Note: These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.

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