IMD Drug Screening for Adenoid Cystic Carcinoma
Trial Summary
Will I have to stop taking my current medications?
The trial protocol does not specify if you need to stop taking your current medications. However, if you are on systemic anticoagulation (blood thinners), this should be discussed with the study's principal investigator and your surgeon.
How is the Implantable Microdevice (IMD) treatment unique for adenoid cystic carcinoma?
The Implantable Microdevice (IMD) is unique because it allows for in-vivo (inside the body) testing of multiple cancer drugs directly within the tumor, helping to identify the most effective treatment without exposing the whole body to the drugs. This personalized approach can optimize treatment strategies by assessing drug response in the tumor's natural environment, which is not possible with standard treatments.12345
What is the purpose of this trial?
This trial tests a tiny device that releases multiple drugs directly into tumors in patients with a specific type of head and neck cancer. The device helps doctors find out which drugs are most effective by analyzing it after it is removed during surgery.
Research Team
Glenn J. Hanna, M.D
Principal Investigator
Dana-Farber Cancer Institute
Eligibility Criteria
This trial is for adults over 18 with adenoid cystic carcinoma of the salivary glands, who are fit for surgery and have a tumor at least 1 cm in size. They must not be pregnant, on other experimental drugs, or have serious illnesses that could risk biopsy/surgery safety.Inclusion Criteria
Exclusion Criteria
Timeline
Screening
Participants are screened for eligibility to participate in the trial
IMD Placement
Interventional radiology guided placement of the implantable microdevice (IMD) into the tumor
Surgical Resection
Planned oncologic resection with IMD retrieval and tumor specimen analysis for local drug response
Adjuvant Treatment
Standard of care adjuvant treatment following surgical resection
Follow-up
Participants are monitored for safety and effectiveness after treatment, including biomarker and gene expression analysis
Treatment Details
Interventions
- Implantable Microdevice (IMD)
Find a Clinic Near You
Who Is Running the Clinical Trial?
Dana-Farber Cancer Institute
Lead Sponsor
Adenoid Cystic Carcinoma Research Foundation
Collaborator
Adenoid Cystic Carcinoma Research Foundation
Collaborator