Brain Monitoring for Speech Perception

Age: 18+

Sex: Any

Trial Phase: Academic

Sponsor: University of Pennsylvania

Disqualifiers: Uncorrected vision, Uncorrected hearing, others

No Placebo Group All trial participants will receive the active study treatment (no placebo)

Compensation: Varies

Number of Visits: Unknown

100 Participants Needed

Trial Summary

Will I have to stop taking my current medications?

The trial information does not specify whether you need to stop taking your current medications.

What data supports the effectiveness of the treatment Intracranial Encephalography for speech perception?

Research shows that intracranial encephalography (iEEG) can help understand how the brain processes speech by separating neural responses to different types of speech, like visual and auditory. This method has been used to study speech perception in epilepsy patients, suggesting it could be useful for improving speech understanding in complex situations. ^{1 2 3 4 5}

Is intracranial encephalography safe for humans?

The research articles do not provide specific safety data for intracranial encephalography, but they discuss its use in clinical settings for speech and brain activity monitoring, suggesting it is used under controlled conditions. ^{1 6 7 8 9}

How does this treatment for speech perception differ from other treatments?

This treatment is unique because it uses brain monitoring with implanted electrodes to directly decode and synthesize speech from brain activity, providing broader coverage and access to deeper brain structures compared to traditional methods that focus on the brain's surface. ^{1 2 10 11 12}

What is the purpose of this trial?

Understanding speech is one of the most important functions of the human brain. We use information from both the auditory modality (the voice the of person we are talking to) and the visual modality (the facial movements of the person we are talking to) to understand speech. We will use intracranial encephalography to study the organization and operation of the brain during audiovisual speech perception.

Eligibility Criteria

This trial is for individuals who are already scheduled to undergo neurosurgery for a brain disorder. Participants must have normal or corrected-to-normal vision and hearing to be eligible.

Inclusion Criteria

I am scheduled for neurosurgery to treat a brain disorder.

Exclusion Criteria

My vision and hearing are normal with correction.

Timeline

Screening

Participants are screened for eligibility to participate in the trial

2-4 weeks

Procedure

Participants undergo intracranial encephalography to study brain activity during audiovisual speech perception

1 day

Follow-up

Participants are monitored for safety and effectiveness after the procedure

4 weeks

Treatment Details

Interventions

• Intracranial Encephalography

Trial Overview The study aims to understand how the human brain processes speech by observing both auditory (sound) and visual (facial movements) information using intracranial encephalography during audiovisual speech perception.

Who Is Running the Clinical Trial?

University of Pennsylvania

Lead Sponsor

Trials

2,118

Recruited

45,270,000+

Columbia University

Collaborator

Trials

1,529

Recruited

2,832,000+

Baylor College of Medicine

Collaborator

Trials

1,044

Recruited

6,031,000+

Findings from Research

A new dataset was created from 10 participants, capturing intracranial EEG data from 1103 electrodes while they read individual words, providing high-resolution insights into the neural processes of speech production.

This dataset can be utilized to enhance our understanding of speech mechanisms and to advance technologies like speech Brain-Computer Interfaces and neuroprostheses, which could help individuals with speech impairments.

NCBI (Pubmed)

pubmed.ncbi.nlm.nih.gov

Dataset of Speech Production in intracranial.Electroencephalography. Verwoert, M., Ottenhoff, MC., Goulis, S., et al.[2022]

In a pilot study involving 8 subjects with refractory epilepsy, a 40-Hz auditory tone significantly reduced interictal epileptiform discharge (IED) rates by an average of 35.25% in those with high baseline IED rates, particularly in mesial and lateral temporal brain regions.

This research suggests that 40-Hz auditory stimulation could serve as a noninvasive adjunctive treatment to help manage IEDs in epilepsy, warranting further investigation in larger populations.

NCBI (Pubmed)

pubmed.ncbi.nlm.nih.gov

40-Hz auditory stimulation for intracranial interictal activity: A pilot study. Quon, RJ., Leslie, GA., Camp, EJ., et al.[2022]

References

1. United States pubmed.ncbi.nlm.nih.gov

Contributions of Stereotactic EEG Electrodes in Grey and White Matter to Speech Activity Detection. [2022]

2. Netherlands pubmed.ncbi.nlm.nih.gov

Cortical bases of speech perception: evidence from functional lesion studies. [2022]

3. United States pubmed.ncbi.nlm.nih.gov

Responses to Visual Speech in Human Posterior Superior Temporal Gyrus Examined with iEEG Deconvolution. [2021]

4. United States pubmed.ncbi.nlm.nih.gov

Lateralized Cerebral Processing of Abstract Linguistic Structure in Clear and Degraded Speech. [2022]

5. England pubmed.ncbi.nlm.nih.gov

Speech Comprehension: Stimulating Discussions at a Cocktail Party. [2019]

6. Netherlands pubmed.ncbi.nlm.nih.gov

Recording EEG in cochlear implant users: Guidelines for experimental design and data analysis for optimizing signal quality and minimizing artifacts. [2022]

7. United States pubmed.ncbi.nlm.nih.gov

A supervised data-driven spatial filter denoising method for speech artifacts in intracranial electrophysiological recordings. [2023]

8. England pubmed.ncbi.nlm.nih.gov

Dataset of Speech Production in intracranial.Electroencephalography. [2022]

9. Denmark pubmed.ncbi.nlm.nih.gov

40-Hz auditory stimulation for intracranial interictal activity: A pilot study. [2022]

10. England pubmed.ncbi.nlm.nih.gov

Analysis of speech sounds is left-hemisphere predominant at 100-150ms after sound onset. [2019]

11. United States pubmed.ncbi.nlm.nih.gov

Multivariate analysis of speech envelope tracking reveals coupling beyond auditory cortex. [2022]

12. Russia (Federation) pubmed.ncbi.nlm.nih.gov

[Mismatch negativity and its hemodynamic equivalent (based on fMRI) in research of speech perception in healthy and in speech disorders]. [2015]