Visudyne

Pathologic myopia, Histoplasmosis retinitis, Subfoveal Choroidal Neovascularization (CNV) + 1 more
Treatment
20 Active Studies for Visudyne

What is Visudyne

VerteporfinThe Generic name of this drug
Treatment SummaryVerteporfin, also known by the brand name Visudyne, is a drug used to treat wet form macular degeneration. The drug is administered and then triggered by nonthermal red light with a wavelength of 693 nm in the presence of oxygen. The light and oxygen activate the drug creating highly reactive substances which damage the blood vessels in the affected area. This blocks the vessels and eliminates abnormal blood vessels.
Visudyneis the brand name
image of different drug pills on a surface
Visudyne Overview & Background
Brand Name
Generic Name
First FDA Approval
How many FDA approvals?
Visudyne
Verteporfin
2000
4

Effectiveness

How Visudyne Affects PatientsVerteporfin, also known as benzoporphyrin derivative, is a medication used with laser treatment to reduce abnormal blood vessels in the eye caused by certain conditions, such as wet macular degeneration. When exposed to red light at a certain wavelength (693 nm) and oxygen, it reacts and produces oxygen radicals that damage the blood vessels and block them.
How Visudyne works in the bodyVerteporfin is spread throughout the body when taken. When activated by light, it creates oxygen molecules that can damage cells. This damage can be used to close off blood vessels in the eye, and form clots. It can also be used to kill tumor cells, because the oxygen molecules it creates are toxic. Verteporfin seems to collect more in newly-formed blood vessels and in the retina.

When to interrupt dosage

The dose of Visudyne relies on the diagnosed situation, including Age-Related Macular Degeneration, Histoplasmosis retinitis and Pathologic myopia. The measure of dosage is contingent upon the approach of delivery recorded in the table beneath.
Condition
Dosage
Administration
Pathologic myopia
, 15.0 mg, 2.0 mg/mL
, Intravenous, Injection, powder, lyophilized, for solution, Injection, powder, lyophilized, for solution - Intravenous, Powder, for solution, Powder, for solution - Intravenous, Injection, powder, for solution, Injection, powder, for solution - Intravenous
Histoplasmosis retinitis
, 15.0 mg, 2.0 mg/mL
, Intravenous, Injection, powder, lyophilized, for solution, Injection, powder, lyophilized, for solution - Intravenous, Powder, for solution, Powder, for solution - Intravenous, Injection, powder, for solution, Injection, powder, for solution - Intravenous
Subfoveal Choroidal Neovascularization (CNV)
, 15.0 mg, 2.0 mg/mL
, Intravenous, Injection, powder, lyophilized, for solution, Injection, powder, lyophilized, for solution - Intravenous, Powder, for solution, Powder, for solution - Intravenous, Injection, powder, for solution, Injection, powder, for solution - Intravenous
Age-Related Macular Degeneration
, 15.0 mg, 2.0 mg/mL
, Intravenous, Injection, powder, lyophilized, for solution, Injection, powder, lyophilized, for solution - Intravenous, Powder, for solution, Powder, for solution - Intravenous, Injection, powder, for solution, Injection, powder, for solution - Intravenous

Warnings

Visudyne Contraindications
Condition
Risk Level
Notes
Porphyria
Do Not Combine
There are 2 known major drug interactions with Visudyne.
Common Visudyne Drug Interactions
Drug Name
Risk Level
Description
Porfimer sodium
Minor
Verteporfin may increase the photosensitizing activities of Porfimer sodium.
Padeliporfin
Moderate
Verteporfin may increase the photosensitizing activities of Padeliporfin.
Visudyne Toxicity & Overdose RiskTaking too much of this drug or exposing the treated eye to too much light may lead to a lack of oxygen in the normal retinal vessels, which can cause a significant decrease in vision that could be permanent. An overdose of the drug may also increase the amount of time a patient is sensitive to bright light.
image of a doctor in a lab doing drug, clinical research

Visudyne Novel Uses: Which Conditions Have a Clinical Trial Featuring Visudyne?

17 active investigations are assessing the potential of Visudyne to address Histoplasmosis retinitis, Pathologic myopia and Age-Related Macular Degeneration.
Condition
Clinical Trials
Trial Phases
Histoplasmosis retinitis
0 Actively Recruiting
Subfoveal Choroidal Neovascularization (CNV)
0 Actively Recruiting
Pathologic myopia
0 Actively Recruiting
Age-Related Macular Degeneration
20 Actively Recruiting
Phase 4, Phase 2, Phase 1, Not Applicable, Early Phase 1, Phase 3

Visudyne Reviews: What are patients saying about Visudyne?

2.7Patient Review
7/21/2008
Visudyne for Histoplasmosis Fungus Disease of the Eye
I had a PDT with Visudyne and an Avastin shot. I lost my sight for five minutes, which was scary, but I felt that the two drugs together worked better than in the past. I was in pain for two days, but I felt like I recovered faster than after my previous treatments.
1.7Patient Review
6/18/2011
Visudyne for Formation of New Blood Vessels in the Choroid of the Eye
Do not use this for eye problems. The after effects have been as if I am poisened.No improvement to my sight but vomiting, nausea, joint pains & stiffness,nervous disorder & trembling in left arm. General feeling of unspecified neurological disturbance at 5 weeks after photo dynamic therapy with Visudyne injection.
1Patient Review
9/13/2011
Visudyne for Age-Related Wet Macular Degeneration
My vision actually worsened after using this treatment for wet macular degeneration.

Patient Q&A Section about visudyne

These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.

Is Visudyne available in USA?

"At this time, there is no Visudyne equivalent available in the US. This means that it is not possible to get the same exact medication from another source. There are fraudulent online pharmacies which may claim to sell a generic version of Visudyne, but this would be illegal."

Answered by AI

What company makes Visudyne?

"Bausch + Lomb strives to provide patients with the best possible treatments for retinal conditions. Our three primary treatments are: Xipere, Visudyne, and Retisert. Xipere is a retinal prosthesis that helps patients to see better. Visudyne is an anti-angiogenic drug that helps to prevent the growth of new blood vessels in the retina. Retisert is a silicone implant that helps to release a continuous stream of medication directly to the back of the eye."

Answered by AI

What is Visudyne used for?

"Verteporfin for injection is used along with laser light treatment to stop leaking from blood vessels in the eye due to the following serious eye conditions: age-related macular degeneration, pathologic myopia, or choroidal neovascularization."

Answered by AI

How much is Visudyne cost?

"A brief guide to the cost of Visudyne: one powder for injection costs approximately $1,800."

Answered by AI

Clinical Trials for Visudyne

Have you considered Visudyne clinical trials? We made a collection of clinical trials featuring Visudyne, we think they might fit your search criteria.
Have you considered Visudyne clinical trials? We made a collection of clinical trials featuring Visudyne, we think they might fit your search criteria.
Have you considered Visudyne clinical trials? We made a collection of clinical trials featuring Visudyne, we think they might fit your search criteria.
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