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What is Ramelteon
RamelteonThe Generic name of this drug
Treatment SummaryRamelteon is a medication used to treat insomnia, specifically delayed sleep onset. It works by binding to the melatonin receptors in the brain and is the first medication of its kind. It is non-habit forming and has no potential for abuse.
Rozeremis the brand name
Ramelteon Overview & Background
Brand Name
Generic Name
First FDA Approval
How many FDA approvals?
Rozerem
Ramelteon
2005
29
Approved as Treatment by the FDA
Ramelteon, also known as Rozerem, is approved by the FDA for 1 uses including Insomnia .Insomnia
Helps manage Insomnia
Effectiveness
How Ramelteon Affects PatientsRamelteon is the first drug specifically designed to imitate the natural hormone melatonin. Melatonin helps regulate our sleep-wake cycle by affecting an area of the brain called the suprachiasmatic nuclei. Ramelteon binds to melatonin receptors located in the suprachiasmatic nuclei and works by mimicking melatonin. It also has an active metabolite that is less potent but circulates in higher concentrations. This metabolite has a weak effect on a receptor called 5HT2b.
How Ramelteon works in the bodyRamelteon helps people fall asleep by mimicking the effects of melatonin. Melatonin is a hormone the body produces in response to darkness that helps signal to the body that it's time to sleep. Ramelteon binds to melatonin receptors in the brain, stimulating sleepiness and aiding in the onset of sleep. It does not interact with any other neurotransmitters, hormones, or receptors, so it only affects the body's sleep cycle.
When to interrupt dosage
The proposed dosage of Ramelteon is contingent upon the established condition. The measure of dosage likewise varies, in accordance with the administration technique enumerated in the table beneath.Condition
Dosage
Administration
Insomnia
, 8.0 mg
, Tablet, film coated, Oral, Tablet, film coated - Oral, Tablet - Oral, Tablet
Warnings
Ramelteon ContraindicationsCondition
Risk Level
Notes
Severe Sleep Apnea
Do Not Combine
Severe Hepatic Impairment
Do Not Combine
Pharmacotherapy
Do Not Combine
Pulse Frequency
Do Not Combine
development of angioedema
Do Not Combine
Common Ramelteon Drug Interactions
Drug Name
Risk Level
Description
Azelastine
Major
Ramelteon may increase the central nervous system depressant (CNS depressant) activities of Azelastine.
Deutetrabenazine
Major
The risk or severity of sedation and somnolence can be increased when Ramelteon is combined with Deutetrabenazine.
Ethanol
Major
Ramelteon may increase the central nervous system depressant (CNS depressant) activities of Ethanol.
Oliceridine
Major
The risk or severity of hypotension, sedation, death, somnolence, and respiratory depression can be increased when Ramelteon is combined with Oliceridine.
Sodium oxybate
Major
Ramelteon may increase the central nervous system depressant (CNS depressant) activities of Sodium oxybate.
Ramelteon Novel Uses: Which Conditions Have a Clinical Trial Featuring Ramelteon?
82 active clinical trials are actively investigating the potential of Ramelteon to provide relief from Insomnia.Condition
Clinical Trials
Trial Phases
Insomnia
91 Actively Recruiting
Phase 4, Not Applicable, Phase 2, Phase 3, Phase 1, Early Phase 1
Ramelteon Reviews: What are patients saying about Ramelteon?
5Patient Review
2/18/2022 I've had insomnia for over a year and have tried everything to get rid of it. This drug, in combination with hormone therapy and stress-reducing techniques like EFT (tapping) and CBT, has finally done the trick. I'm so grateful!
4.3Patient Review
4/9/2008 I've been struggling to fall asleep soundly for months, but this treatment has finally helped me. I didn't experience any of the negative side effects that I did with other medications, which is great. It took a little while to really take effect (about a week), but it was worth the wait!
4Patient Review
10/23/2007 I experienced some strange dreams while taking this medication, but they weren't bothersome enough to outweigh the positives.
3.3Patient Review
3/7/2021 I find that this medication makes me drowsy during the day, to the point where people might think I'm abusing drugs. I also wake up in the middle of the night and can't fall back asleep. All things considered, I think it's better to just not take this medication.
3.3Patient Review
12/21/2009 I get a headache every morning after taking this medication, but I'm also taken several others that list drowsiness as a potential side effect.
2.7Patient Review
12/26/2007 This medication really helped me fall asleep quickly, but unfortunately I didn't stay asleep for very long.
2.3Patient Review
2/11/2011 I'm still chronically sleepless, taking the recommended 8mg dosage. I sometimes can manage a short nap in the afternoon, but that's about it.
2.3Patient Review
12/3/2020 The cost of this treatment is unfortunately quite high, and I didn't find it helpful for my insomnia at all.
2Patient Review
6/14/2021 If this medication worked as intended, it would be great. Unfortunately, more often than not it fails to deliver on its promises. When that happens, I end up feeling extremely depressed and sleepless. The next day is always a total wash for me energy-wise. Thankfully, I was able to quit after just six days of use.
1.3Patient Review
4/17/2010 Both times I took this medication, I woke up a few hours later unable to fall back asleep. In addition, the next morning I noticed my face was swollen. This has led me to believe that Ambien would be better for me.
1Patient Review
4/1/2019 I've given this medication a month's chance, and it has not helped me sleep in the slightest. If anything, I feel more exhausted from lack of sleep and taking this pill. I'm seeing my psychiatrist soon to ask for something else; Ambien made me feel horrible the next day, Belsomra and Rozerem did nothing at all, while Xanax sometimes worked. 100% reliable help is what I need every night; insomnia is already too much to handle!
1Patient Review
2/3/2020 This treatment did not help me sleep.
Patient Q&A Section about ramelteon
These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.What are the side effects of ramelteon?
"Symptoms may include: lightheadedness, fatigue, excessive sleepiness during the day, nausea, or worsening sleep problems."
Answered by AI
Is ramelteon a sleeping pill?
"Ramelteon is a treatment for insomnia, characterized by difficulty falling asleep or staying asleep. Ramelteon helps patients fall asleep more quickly and sleep more soundly throughout the night. Over time, however, sleep medications like this one may become less effective if taken every night."
Answered by AI
Is ramelteon the same as melatonin?
"Ramelteon (Rozerem) and melatonin are not the same, but both work in the same areas of the brain to help maintain a regular sleep cycle. Ramelteon (Rozerem) is a medication approved by the FDA to treat insomnia. Melatonin is a natural hormone your body makes and is also available as a supplement."
Answered by AI
Is ramelteon similar to Ambien?
"Rozerem is a sleeping medication that is not habit-forming, unlike some other sleep medications."
Answered by AI