Pradaxa

Deep Vein Thrombosis (DVT), Deep Vein Thrombosis, Pulmonary Embolism + 12 more
Treatment
12 FDA approvals
20 Active Studies for Pradaxa

What is Pradaxa

Dabigatran etexilateThe Generic name of this drug
Treatment SummaryDabigatran etexilate is a medication that helps prevent blood clots by inhibiting thrombin, an enzyme involved in clotting. It is taken orally and is converted to a drug called dabigatran when it is metabolized in the body. It was approved by the FDA in 2010 and is commonly prescribed to prevent venous thromboembolic events. Unlike warfarin, it does not require monitoring with lab tests, making it a convenient treatment option.
Pradaxais the brand name
image of different drug pills on a surface
Pradaxa Overview & Background
Brand Name
Generic Name
First FDA Approval
How many FDA approvals?
Pradaxa
Dabigatran etexilate
2010
23

Approved as Treatment by the FDA

Dabigatran etexilate, also known as Pradaxa, is approved by the FDA for 12 uses including Recurrent Pulmonary Embolism (Disorder) and Deep Vein Thrombosis .
Recurrent Pulmonary Embolism (Disorder)
Deep Vein Thrombosis
Prophylaxis of Deep Vein Thrombosis
Deep vein thrombosis recurrent
Pulmonary Embolism
Pulmonary Embolism
Total Knee Arthroplasty
Deep Vein Thrombosis
Pulmonary Embolism
Disease
Deep Vein Thrombosis
recurrent Prophylaxis of Deep Vein Thrombosis

Effectiveness

How Pradaxa Affects PatientsDabigatran is a type of medicine that prevents blood clots. Its effects can be seen through longer clotting times in tests like the activated partial thromboplastin time (aPTT), ecarin clotting time (ECT), thrombin time (TT), and dilute thrombin time (dTT). There is an increased risk of bleeding when taking dabigatran, especially if taken with other medicines like antiplatelet agents, fibrinolytic therapy, heparins, or NSAIDs. It should not be used with neuraxial anesthesia or spinal puncture as it
How Pradaxa works in the bodyDabigatran works to balance coagulation in the body. Normally, thrombin, a serine protease, activates prothrombin which then forms fibrin fibres and platelets to form clots. Too much clotting can be bad for your health and so dabigatran is used to reduce thrombin activity. Dabigatran is a reversible direct thrombin inhibitor which means it can be turned on and off, allowing some normal clotting activity to occur. It also inhibits platelet aggregation, though the exact mechanism is unknown.

When to interrupt dosage

The proposed dosage of Pradaxa is contingent upon the diagnosed condition, such as Systemic Embolism, Deep Vein Thrombosis and recurrent Prophylaxis of Deep Vein Thrombosis. The measure of dosage can be found in the subsequent table, depending on the technique of delivery (e.g. Capsule - Oral or Capsule).
Condition
Dosage
Administration
Systemic Embolism
, 150.0 mg, 75.0 mg, 110.0 mg, 6.25 mg/mL, 30.0 mg, 50.0 mg, 20.0 mg, 40.0 mg
, Oral, Capsule, Capsule - Oral, Capsule, coated pellets - Oral, Capsule, coated pellets, Pellet, Pellet - Oral
Disease
, 150.0 mg, 75.0 mg, 110.0 mg, 6.25 mg/mL, 30.0 mg, 50.0 mg, 20.0 mg, 40.0 mg
, Oral, Capsule, Capsule - Oral, Capsule, coated pellets - Oral, Capsule, coated pellets, Pellet, Pellet - Oral
Stroke
, 150.0 mg, 75.0 mg, 110.0 mg, 6.25 mg/mL, 30.0 mg, 50.0 mg, 20.0 mg, 40.0 mg
, Oral, Capsule, Capsule - Oral, Capsule, coated pellets - Oral, Capsule, coated pellets, Pellet, Pellet - Oral
Pulmonary Embolism
, 150.0 mg, 75.0 mg, 110.0 mg, 6.25 mg/mL, 30.0 mg, 50.0 mg, 20.0 mg, 40.0 mg
, Oral, Capsule, Capsule - Oral, Capsule, coated pellets - Oral, Capsule, coated pellets, Pellet, Pellet - Oral
Total Knee Arthroplasty
, 150.0 mg, 75.0 mg, 110.0 mg, 6.25 mg/mL, 30.0 mg, 50.0 mg, 20.0 mg, 40.0 mg
, Oral, Capsule, Capsule - Oral, Capsule, coated pellets - Oral, Capsule, coated pellets, Pellet, Pellet - Oral
following at least 5 days of initial therapy with a parenteral anticoagulant
, 150.0 mg, 75.0 mg, 110.0 mg, 6.25 mg/mL, 30.0 mg, 50.0 mg, 20.0 mg, 40.0 mg
, Oral, Capsule, Capsule - Oral, Capsule, coated pellets - Oral, Capsule, coated pellets, Pellet, Pellet - Oral
Atrial Fibrillation
, 150.0 mg, 75.0 mg, 110.0 mg, 6.25 mg/mL, 30.0 mg, 50.0 mg, 20.0 mg, 40.0 mg
, Oral, Capsule, Capsule - Oral, Capsule, coated pellets - Oral, Capsule, coated pellets, Pellet, Pellet - Oral
previously treated
, 150.0 mg, 75.0 mg, 110.0 mg, 6.25 mg/mL, 30.0 mg, 50.0 mg, 20.0 mg, 40.0 mg
, Oral, Capsule, Capsule - Oral, Capsule, coated pellets - Oral, Capsule, coated pellets, Pellet, Pellet - Oral
Deep Vein Thrombosis
, 150.0 mg, 75.0 mg, 110.0 mg, 6.25 mg/mL, 30.0 mg, 50.0 mg, 20.0 mg, 40.0 mg
, Oral, Capsule, Capsule - Oral, Capsule, coated pellets - Oral, Capsule, coated pellets, Pellet, Pellet - Oral
Pulmonary Embolism
, 150.0 mg, 75.0 mg, 110.0 mg, 6.25 mg/mL, 30.0 mg, 50.0 mg, 20.0 mg, 40.0 mg
, Oral, Capsule, Capsule - Oral, Capsule, coated pellets - Oral, Capsule, coated pellets, Pellet, Pellet - Oral
Pulmonary Embolism
, 150.0 mg, 75.0 mg, 110.0 mg, 6.25 mg/mL, 30.0 mg, 50.0 mg, 20.0 mg, 40.0 mg
, Oral, Capsule, Capsule - Oral, Capsule, coated pellets - Oral, Capsule, coated pellets, Pellet, Pellet - Oral
Hip structure
, 150.0 mg, 75.0 mg, 110.0 mg, 6.25 mg/mL, 30.0 mg, 50.0 mg, 20.0 mg, 40.0 mg
, Oral, Capsule, Capsule - Oral, Capsule, coated pellets - Oral, Capsule, coated pellets, Pellet, Pellet - Oral
Deep Vein Thrombosis (DVT)
, 150.0 mg, 75.0 mg, 110.0 mg, 6.25 mg/mL, 30.0 mg, 50.0 mg, 20.0 mg, 40.0 mg
, Oral, Capsule, Capsule - Oral, Capsule, coated pellets - Oral, Capsule, coated pellets, Pellet, Pellet - Oral
Deep Vein Thrombosis
, 150.0 mg, 75.0 mg, 110.0 mg, 6.25 mg/mL, 30.0 mg, 50.0 mg, 20.0 mg, 40.0 mg
, Oral, Capsule, Capsule - Oral, Capsule, coated pellets - Oral, Capsule, coated pellets, Pellet, Pellet - Oral
recurrent Prophylaxis of Deep Vein Thrombosis
, 150.0 mg, 75.0 mg, 110.0 mg, 6.25 mg/mL, 30.0 mg, 50.0 mg, 20.0 mg, 40.0 mg
, Oral, Capsule, Capsule - Oral, Capsule, coated pellets - Oral, Capsule, coated pellets, Pellet, Pellet - Oral

Warnings

Pradaxa has three contraindications which preclude its combination with the conditions given in the below table.Pradaxa Contraindications
Condition
Risk Level
Notes
mechanical prosthetic heart valve
Do Not Combine
Hemorrhage
Do Not Combine
Severe Hypersensitivity Reactions
Do Not Combine
Dabigatran Etexilate may interact with Pulse Frequency
There are 20 known major drug interactions with Pradaxa.
Common Pradaxa Drug Interactions
Drug Name
Risk Level
Description
(R)-warfarin
Major
Dabigatran etexilate may increase the anticoagulant activities of (R)-warfarin.
(S)-Warfarin
Major
Dabigatran etexilate may increase the anticoagulant activities of (S)-Warfarin.
4-hydroxycoumarin
Major
Dabigatran etexilate may increase the anticoagulant activities of 4-hydroxycoumarin.
Abciximab
Major
Dabigatran etexilate may increase the anticoagulant activities of Abciximab.
Acenocoumarol
Major
Dabigatran etexilate may increase the anticoagulant activities of Acenocoumarol.
Pradaxa Toxicity & Overdose RiskThere is not enough data available to know the effects of dabigatran on pregnant women, labor and delivery, nursing mothers, or children. Elderly people may be more likely to experience side effects, but the drug can still be beneficial. People with reduced kidney function should take a lower dose of the drug. Animal studies have shown that dabigatran can lead to dead offspring and bleeding near the time of birth. It is unknown whether the drug is passed through breast milk, so the potential risks must be weighed against the benefits before taking it or breastfeeding.
image of a doctor in a lab doing drug, clinical research

Pradaxa Novel Uses: Which Conditions Have a Clinical Trial Featuring Pradaxa?

99 active clinical trials are currently investigating the potential of Pradaxa to provide relief from Pulmonary Embolism, Anticoagulant Therapy and Systemic Embolism.
Condition
Clinical Trials
Trial Phases
Pulmonary Embolism
25 Actively Recruiting
Phase 4, Phase 3, Early Phase 1, Not Applicable
Systemic Embolism
3 Actively Recruiting
Not Applicable
recurrent Prophylaxis of Deep Vein Thrombosis
0 Actively Recruiting
Disease
0 Actively Recruiting
Total Knee Arthroplasty
6 Actively Recruiting
Not Applicable, Phase 2, Phase 3, Phase 4
Atrial Fibrillation
4 Actively Recruiting
Not Applicable
Deep Vein Thrombosis (DVT)
25 Actively Recruiting
Phase 4, Early Phase 1, Phase 3, Phase 2, Not Applicable
Stroke
9 Actively Recruiting
Phase 4, Phase 1, Not Applicable
Pulmonary Embolism
0 Actively Recruiting
Deep Vein Thrombosis
0 Actively Recruiting
Pulmonary Embolism
0 Actively Recruiting
following at least 5 days of initial therapy with a parenteral anticoagulant
0 Actively Recruiting
Deep Vein Thrombosis
10 Actively Recruiting
Not Applicable, Phase 2, Phase 3, Phase 4
previously treated
0 Actively Recruiting
Hip structure
0 Actively Recruiting

Pradaxa Reviews: What are patients saying about Pradaxa?

5Patient Review
2/9/2016
Pradaxa for Treatment to Prevent Blood Clots in Chronic Atrial Fibrillation
I was disappointed when I received my last refill in the form of a blister package instead of a bottle. It's not safe to have to use scissors to remove the pill, and there's no way to see the pill itself through the packaging. This could easily lead to damaging the pill.
4.7Patient Review
12/19/2014
Pradaxa for Treatment to Prevent a Blood Clot in the Lung
I've been taking this treatment for three years now and it seems to be working well. I don't have excessive bleeding or bruising, which is great.
4.3Patient Review
10/16/2017
Pradaxa for Treatment to Prevent Blood Clots in Chronic Atrial Fibrillation
I became anemic after seven years on this medication. I would recommend getting your blood checked frequently while taking this drug.
3.7Patient Review
10/16/2014
Pradaxa for Deep Vein Thrombosis Prevention
I had a DVT and PE about 10 years ago. I was initially put on Coumadin/Warfarin for treatment, but then I got another PE. So, my hematologist switched me to Lovenox injections, which are quite expensive. Then Pradaxa came out and I thought it was amazing. But after being on it for a while, I developed severe hemorrhoids. My hematologist denied that the medication was the cause, but after switching to Xarelto, my hemorrhoids cleared up within a week.
3.7Patient Review
9/22/2014
Pradaxa for Deep Vein Thrombosis Prevention
I had another pulmonary embolism while on coumadin, and the only available option at the time was heparin injections. These were quite expensive, so I took them for two years until Pradaxa became available. However, after being on Pradaxa for a month or so, I developed hemorrhoids which grew progressively worse. My hemotologist insisted that this drug wasn't the cause of my hemorrhoids but agreed to switch me to Xarelto instead. I've been happily taking Xarelto for over a year now with no side effects whatsoever.
View All Reviews
image of drug pills surrounding a glass of water symbolizing drug consumption

Patient Q&A Section about pradaxa

These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.

What's the difference between Eliquis and Pradaxa?

"Eliquis and Pradaxa work by blocking the action of clotting factors in your blood. Eliquis blocks factor Xa, and Pradaxa blocks thrombin. This prevents blood clots from forming in your blood vessels."

Answered by AI

What foods should you avoid while taking Pradaxa?

"There are no dietary restrictions. However, you may need to limit many foods with vitamin K, such as leafy green vegetables and some vegetable oils. This is because vitamin K can affect the way warfarin works in your body."

Answered by AI

What is the drug Pradaxa used for?

"Pradaxa is a medication used to thin the blood and prevent the formation of blood clots. It is commonly used after surgery or in patients with an abnormal heart beat."

Answered by AI

What is the most common side effect of Pradaxa?

"Pradaxa is most commonly associated with bleeding, as it inhibits the body's ability to clot. This can manifest as increased bruising or longer bleeding after cuts or injuries."

Answered by AI

Clinical Trials for Pradaxa

Have you considered Pradaxa clinical trials? We made a collection of clinical trials featuring Pradaxa, we think they might fit your search criteria.
Have you considered Pradaxa clinical trials? We made a collection of clinical trials featuring Pradaxa, we think they might fit your search criteria.
Have you considered Pradaxa clinical trials? We made a collection of clinical trials featuring Pradaxa, we think they might fit your search criteria.
Unbiased ResultsWe believe in providing patients with all the options.
Your Data Stays Your DataWe only share your information with the clinical trials you're trying to access.
Verified Trials OnlyAll of our trials are run by licensed doctors, researchers, and healthcare companies.
Back to top