Depression Clinical Trials in Boston

View 54 new treatments for depression near you in Boston, MA. Every day, Power helps over 527 depression patients connect with leading medical research.

ALTO-300 for Depression

Alto Neuroscience Clinic, Boston + 3 more

This trial is testing ALTO-300, a new medication, to see if it can make antidepressants work better for patients who are already taking them.

Verified

Recruiting
Phase 2
Est. 3 - 12 Weeks
Adam Savitz, MD, PhD
Study Director

BI 1569912 for Depression

Boehringer Ingelheim Clinic, Boston + 4 more

This trial tests a new medicine, BI 1569912, for adults with depression who haven't improved with other treatments. Participants take the medicine daily while continuing their usual therapy. The study checks if the new medicine helps reduce depression symptoms.Show More

Verified

Recruiting
Phase 2
Est. 6 - 12 Weeks
Unregistered Study Lead
Research Team

TMS for Depression

Research Clinic, Boston + 1 more

The goal of this clinical trial is to test a new brain stimulation treatment target for individuals with depression plus at least one additional psychiatric disorder. The main question is to understand the safety profile of a non-invasive form of brain stimulation called accelerated intermittent theta burst stimulation when it is targeting the posterior parietal cortex. Additional questions focus on whether this stimulation improves symptoms of depression and other psychiatric disorders as well as whether this stimulation changes brain function.Show More
Recruiting

No Placebo Trial

Phase < 1
Est. 4 - 6 Weeks
Joseph J Taylor, MD, PhD
Principal Investigator

Xenon Inhalation Therapy for Depression

Research Clinic, Boston + 1 more

The investigators will test the hypothesis that inhaled xenon will produce a rapid improvement in depressive symptoms in patients suffering from treatment-resistant depression. Specifically, the investigators will conduct a parallel randomized, double-blind crossover study that will compare the effects of xenon-oxygen (35:65 ratio by volume) added to treatment as usual (X-TAU group) to the effects of nitrogen-oxygen (35:65 ratio by volume) added to treatment as usual (N-TAU group). A total of 20 severely depressed patients, 10 with major depressive disorder (MDD) and 10 with Bipolar Depression (BP), will be exposed in random order to N-TAU and X-TAU in a double-blind protocol.Show More
Recruiting
Phase < 1
Est. 6 - 12 Weeks
Andrew Nierenberg, MD
Principal Investigator

AXS-05 for Depression

Axsome Clinic, Boston + 1 more

This trial is testing AXS-05, a new medication, to see if it can prevent depression from returning in people who have already improved with it. The study focuses on those with major depressive disorder and aims to maintain their balanced brain chemicals to keep them feeling better. AXS-05 (a combination of dextromethorphan and bupropion) has shown positive results in previous trials for major depressive disorder.Show More
Recruiting

No Placebo Trial

Phase 4
Est. 3 - 12 Weeks
Unregistered Study Lead
Research Team

Antidepressants for Depression

Research Clinic, Belmont + 1 more

The main goal of this research is to use behavioral, brain, and clinical data to determine which type of antidepressant might be optimal before people with depression start treatment.Show More
Recruiting

No Placebo Trial

Phase 4
Est. 6 - 12 Weeks
Diego A. Pizzagalli, PhD
Principal Investigator

Multiple Medications for Bipolar Depression

Research Clinic, Belmont + 2 more

This trial is testing four different medications to find the best treatment for adults with bipolar disorder type 1 who are currently depressed. The medications work by balancing brain chemicals that affect mood. The goal is to help patients recover from depression and stay well.Show More
Waitlist

No Placebo Trial

Phase 4
Est. 3 - 6 Weeks
Unregistered Study Lead
Research Team

ECT vs. Ketamine for Depression

Research Clinic, Belmont + 2 more

This trial compares two treatments for patients with severe depression who are at risk of suicide. One treatment uses electric currents to change brain activity, while the other uses a low dose of a fast-acting drug. The goal is to find out which treatment works better for rapid relief. The drug has recently emerged as a fast-acting alternative for patients with treatment-resistant depression.Show More
Waitlist

No Placebo Trial

Phase 4
Est. 3 - 6 Weeks
Amit Anand, MD
Principal Investigator

Brexanolone for Depression in Perimenopausal Women

Research Clinic, Boston + 1 more

This study aims to identify how the progesterone metabolite allopregnanolone affects behavior and neurobiology that may underlie perimenopausal depression.
Recruiting
Phase 4
Est. 3 - 6 Weeks
Unregistered Study Lead
Research Team

Ketamine + Esketamine for Depression

Research Clinic, Boston + 1 more

The study will consist of a 24-week-long trial examining outcomes in patients with Major Depressive Disorder and suicidal ideation who will receive intravenous (IV) ketamine and intranasal (IN) esketamine, compared to a large sample of matched historical controls. Patients will be recruited from an inpatient psychiatric unit. Eligible patients who provided informed consent will be enrolled in the study that will include a eight IV ketamine treatments, 13 esketamine treatment visits, seven long assessment visits, five short assessment visits, and daily surveys. The study will examine the feasibility, tolerability, and efficacy of repeated IV ketamine followed by esketamine, as well as predictors of treatment response.Show More
Recruiting

No Placebo Trial

Phase 4
Est. 5 - 8 Weeks
Unregistered Study Lead
Research Team
Page 1 of 10

Frequently Asked Questions

How much do depression clinical trials pay?

Each trial will compensate patients a different amount, but $50-100 for each visit is a fairly common range. Further, most trials will cover the costs of an Uber to-and-from the clinic. Factors that can affect compensation include the phase of the trial, the length of the trial, the frequency of visits, and the specific condition being studied.

Do I need to be insured to participate in a medical study?

Clinical trials are almost always free to participants, and so do not require insurance. The only exception here are trials focused on Cancer, because only a small part of the typical treatment plan is actually experimental. For these cancer trials, participants typically need insurance to cover all the non-experimental components.

How do depression clinical trials work?

After a researcher reviews your profile, they may choose to invite you in to a screening appointment, where they'll determine if you meet 100% of the eligibility requirements. If you do, you'll typical be sorted into one of the treatment groups, and will receive your study drug. For some trials, there is a chance you'll receive a placebo. Across depression trials in Boston, 42% of clinical trials have a placebo. Typically you'll be required to check-in with the clinic every month or two. The average trial length in this city for depression patients is 6 Months.

What does the "phase" of a clinical trial mean?

The phase of a trial reveals what stage the drug is in getting approval for a specific condition. Phase 3 trials are in the final step before approval. The drug already has data showing both safety and effectiveness. Phase 2 trials are those where the drug has some data showing safety in humans, but where effectiveness has typically only been shown in animals and non-human experiments. Phase 1 trials are the trials where we don't have safety data in humans. As a general rule, phase 3 trials are more promising than phase 2, and phase 2 trials are more promising than phase 1.

Why are others applying to these studies?

  • I have tried two other drugs that didn't have any positive affect on my mental health and am hoping that trying out this trial will help me find a solution.

    M.A. Patient

    Depression Patient

  • I've tried many anti-depressants in my 45 year struggle with Major Depression. I'm hoping this study is the 'game changer'

    B.E. Patient

    Late-Life Depression Patient

  • I've tried more then 5 drugs for depression and it's very depressing frustrating when they do not work, or even help nothing, I'm still looking for that one or 2 that will help

    A.L. Patient

    Major Depression Patient