X-TAU (xenon) for Depression

Dauten Family Center for Bipolar Treatment Innovation, Boston, MA
Depression+1 More ConditionsXenon - Drug
18 - 65
All Sexes
What conditions do you have?

Study Summary

This trial is testing whether inhaling xenon gas can help people with treatment-resistant depression. The study is comparing the effects of adding xenon to treatment as usual to adding nitrogen to treatment as usual.

Eligible Conditions
  • Depression
  • Depression, Bipolar Disorder

Treatment Effectiveness

Phase-Based Effectiveness

1 of 3
Phase < 1

Similar Trials

Study Objectives

1 Primary · 0 Secondary · Reporting Duration: Improvement at day 1

Improvement at day 1
Depressive Symptoms

Trial Safety

Phase-Based Safety

1 of 3

Similar Trials

Trial Design

2 Treatment Groups

X-TAU (xenon)
1 of 2
N-TAU (nitrogen-placebo)
1 of 2

Active Control

Non-Treatment Group

20 Total Participants · 2 Treatment Groups

Primary Treatment: X-TAU (xenon) · Has Placebo Group · Phase < 1

N-TAU (nitrogen-placebo)
PlaceboComparator Group · 1 Intervention: Nitrogen gas · Intervention Types: Drug
X-TAU (xenon)
ActiveComparator Group · 1 Intervention: Xenon · Intervention Types: Drug

Trial Logistics

Trial Timeline

Screening: ~3 weeks
Treatment: Varies
Reporting: improvement at day 1

Who is running the clinical trial?

Massachusetts General HospitalLead Sponsor
2,782 Previous Clinical Trials
31,225,181 Total Patients Enrolled
178 Trials studying Depression
30,592 Patients Enrolled for Depression
Andrew Nierenberg, MDPrincipal InvestigatorMassachussetts General Hospital
2 Previous Clinical Trials
73 Total Patients Enrolled
2 Trials studying Depression
73 Patients Enrolled for Depression

Eligibility Criteria

Age 18 - 65 · All Participants · 2 Total Inclusion Criteria

Mark “Yes” if the following statements are true for you:
You have either Major Depressive Disorder or Bipolar Depression, and that is the main condition that needs to be treated.
If you have depression, you must have been taking your antidepressant medication for at least four weeks before enrolling in the study. If you have bipolar disorder, you must have been on a stable mood stabilizing medication for at least four weeks before enrolling.

Frequently Asked Questions

Is this medical experiment open to individuals younger than fifty-five years of age?

"In order to participate in this trial, subjects must be aged between 18 and 65. There are 418 medical studies with a lower age threshold and 1503 trials open for those beyond the upper limit of 65 years old." - Anonymous Online Contributor

Unverified Answer

Is this research actively enrolling participants?

"Affirmative. Data hosted on clinicaltrials.gov states that this medical study is currently recruiting individuals, with 20 participants sought from a single centre. The trial was initiated on December 5th 2019 and last updated February 23rd 2022." - Anonymous Online Contributor

Unverified Answer

Is there an eligibility criteria for enrolling in this clinical research?

"In order to gain entry into this medical trial, an individual must experience psychosis, involutional depression, and be between 18-65 years old. The total number of participants required for the study is 20 individuals." - Anonymous Online Contributor

Unverified Answer

What is the participant quota for this medical study?

"Affirmative. According to the information provided by clinicaltrials.gov, this medical research is actively enrolling patients that meet its criteria; it was first made public on December 5th 2019 and recently updated on February 23rd 2022. The trial seeks 20 participants from a single location." - Anonymous Online Contributor

Unverified Answer

What prior investigations have utilized xenon as an element?

"Currently, 18 independent research projects are being conducted on X-TAU (xenon), none of which have reached Phase 3. Philadelphia, Pennsylvania hosts the majority of these trials; however 25 different sites have trials open for this drug's efficacy." - Anonymous Online Contributor

Unverified Answer

What clinical conditions commonly warrant the use of X-TAU (xenon)?

"X-TAU (xenon) is usually used to treat actinic keratosis, yet it also has the potential of managing hypoxemia, respiratory challenge test and certain types of verruca (warts)." - Anonymous Online Contributor

Unverified Answer
Please Note: These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.