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Neuromodulation

Neuromodulation for Hoarding Disorder and Depression

N/A

Recruiting

Led By Elizabeth Twamley, PhD

Research Sponsored by University of California, San Diego

Eligibility Criteria Checklist

Specific guidelines that determine who can or cannot participate in a clinical trial

Must have

Be older than 18 years old

Timeline

Screening 3 weeks

Treatment Varies

Follow Up change from baseline to 8 weeks

Awards & highlights

Study Summary

This trial will evaluate if iTBS can effectively treat depression in people with HD, and how it can potentially improve HD symptoms, cognitive performance, and brain region connectivity.

Who is the study for?

This trial is for adults aged 18-70 with both depression and hoarding disorder, who have been stable on psychiatric meds for 6 weeks. They must be able to commit to the treatment schedule, complete assessments in English, and not have any MRI or TMS contraindications. Pregnant individuals or those with certain neurological conditions or high suicide risk are excluded.Check my eligibility

What is being tested?

The study tests intermittent theta burst stimulation (iTBS) effectiveness on treating depression in patients also suffering from chronic hoarding disorder. It will assess improvements in hoarding symptoms, cognitive function, and brain connectivity related to the treatment.See study design

What are the potential side effects?

While specific side effects of iTBS aren't listed here, common ones include discomfort at the stimulation site, headache, lightheadedness, and seizures are a rare but serious risk especially if there's a history of seizures.

Timeline

Screening ~ 3 weeks3 visits

Treatment ~ Varies

Follow Up ~ change from baseline to 8 weeks

Screening ~ 3 weeks

Treatment ~ Varies

Follow Up ~change from baseline to 8 weeks

This trial's timeline: 3 weeks for screening, Varies for treatment, and change from baseline to 8 weeks for reporting.

Treatment Details

Study Objectives

Outcome measures can provide a clearer picture of what you can expect from a treatment.

Primary outcome measures

Hamilton Rating Scale for Depression

Savings Inventory -- Revised

Secondary outcome measures

Hoarding Rating Scale

Neuropsychological Global Deficit Score

Patient Health Questionnaire - 9

+1 more

Trial Design

1Treatment groups

Experimental Treatment

Group I: iTBSExperimental Treatment1 Intervention

intermittent Theta Burst Stimulation (a form of transcranial magnetic stimulation) targeting the left dorsolateral prefrontal cortex

Treatment

First Studied

Drug Approval Stage

How many patients have taken this drug

iTBS

2019

Completed Phase 3

~640

Do I qualify?Apply below to find out

Find a Location

Who is running the clinical trial?

University of California, San DiegoLead Sponsor

1,122 Previous Clinical Trials

1,521,032 Total Patients Enrolled

29 Trials studying Depression

56,166 Patients Enrolled for Depression

Elizabeth Twamley, PhDPrincipal InvestigatorUC San Diego

2 Previous Clinical Trials

136 Total Patients Enrolled

1 Trials studying Depression

72 Patients Enrolled for Depression

Media Library

Depression Clinical Trial 2023: iTBS Highlights & Side Effects. Trial Name: NCT05985356 — N/A

iTBS (Neuromodulation) 2023 Treatment Timeline for Medical Study. Trial Name: NCT05985356 — N/A

Frequently Asked Questions

These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.

Does this trial allow adults aged 20 and above to participate?

"Eligibility for this trial extends to individuals between the age of majority and 70 years old."

Answered by AI

Am I eligible to enroll for this medical experiment?

"Patients who are diagnosed with depression and of age 18-70 can qualify to partake in this trial, which seeks 12 participants."

Answered by AI

What is the ambition of this trial?

"This experiment is primarily concerned with assessing the alteration of the Hamilton Rating Scale for Depression from pre-treatment to 8 weeks post-intervention. Secondary objectives include monitoring self-reported depression symptoms via Patient Health Questionnaire - 9, gauging neurocognitive performance through Neuropsychological Global Deficit Score measurements, and utilizing functional magnetic resonance imaging to observe connections between subgenual nucleus accumbens and dorsolateral prefrontal cortex in a resting state."

Answered by AI

Is enrollment open for the experiment at present?

"Affirmative. Information on clinicaltrials.gov states that this medical trial has recently reopened for participants, with the original posting dated August 1st 2023 and an update made on August 9th of the same year. The study is currently recruiting 12 individuals from one location."

Answered by AI

How many participants are being recruited to participate in this experiment?

"Affirmative. Clinicaltrials.gov has evidence that this research project is still seeking out participants; it was initially posted on August 1st 2023 and updated on the 9th of the same month. The study requires 12 individuals to be recruited from one site."

Answered by AI

Recent research and studies

clinicaltrials.govStudy

Neuromodulation for Comorbid Hoarding Disorder and Depression

Elizabeth Twamley 2023. "Neuromodulation for Comorbid Hoarding Disorder and Depression". ClinicalTrials.gov. https://clinicaltrials.gov/ct2/show/NCT05985356.

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