Tinnitus Clinical Trials 2023

Tinnitus studies recruiting patients for novel treatments. Filter by phase, distance, and inclusion criteria to find your perfect tinnitus clinical trial in 2023.

Reviewed by Michael Gill, B. Sc.
Image of U.S. Army Aeromedical Research Laboratory in Fort Rucker, United States.
Phase-Based Progress Estimates

Oasis™ Devicefor Tinnitus

18 - 60
All Sexes
Fort Rucker, AL
The most current data indicate that tinnitus and hearing impairment are the Number 1 and 2 disabilities associated with service in Operations Iraqi Freedom and Enduring Freedom. Tinnitus can result from exposure to continuous noise from vehicles, generators, and other equipment, and from blast, or impulse noise from friendly-or opposing-forces weapon systems. Thus, tinnitus caused by both long-term noise exposure and acute acoustic trauma is an obstacle to be overcome in return-to-duty decisions and represents a serious liability to the retention of a healthy and fit force. Until recently, there has been no treatment that has been clinically validated as consistently effective. The development of the Neuromonics Tinnitus Treatment sought to overcome the practical limitations of previously available approaches (e.g. tinnitus maskers and biofeedback). While these studies have demonstrated the efficacy of the Neuromonics Tinnitus Treatment over alternative therapies, these trials studied target populations that may not be representative of the typical Soldier experiencing tinnitus. One hundred and twenty (120) Soldiers or veterans with debilitating tinnitus will be recruited and divided into groups treated with two treatments, the Neuromonics Tinnitus Treatment Program which includes the use of the Neuromonics Oasis™ treatment device and a similarly-treated device using a placebo treatment. The study uses a randomized, double-blind design. The effectiveness of the treatments will be assessed using standard audiometric procedures and tinnitus subjective questionnaires. This study will allow the Office of the Surgeon General of the Army to provide direction regarding the Neuromonics Tinnitus Treatment Program (NTTP) for alleviation of debilitating tinnitus that adversely affects Soldier deployability and operational performance. Retention of a fit force and improved quality of life for active-duty Soldiers are important issues associated with a successful approach to the treatment of tinnitus.
Waitlist Available
U.S. Army Aeromedical Research LaboratoryWilliam A Ahroon, Ph.D.
10 Tinnitus Clinical Trials Near Me

What Are Tinnitus Clinical Trials?

Tinnitus is an auditory disease symptom associated with ringing, buzzing, or whooshing in one or both ears. More than 200 conditions are associated, including ear infections. Though tinnitus may be a temporary symptom of an acute condition, this auditory condition is permanent for one in eight individuals. It is experience by more than 25 million Americans each year.

Although it commonly presents as ‘ringing in ears’ tinnitus can manifest many different perceptions of sounds. It can be both an acute and chronic health condition.

Clinical trials for tinnitus aim to find drug therapies that desensitize the auditory system, thereby inhibiting the perception of the ringing sound. However, there are no reliable prognostic tools to determine the severity of a patient's tinnitus. Therefore, tinnitus clinical trials rely exclusively on patient interviews.

Why Is Tinnitus Being Studied Through Clinical Trials?

Despite the first cases of tinnitus dating back to 1600 BC, scientists are yet to find a cure for this condition. It is thought that the complexity of the auditory system and the mysterious etiology of tinnitus are the reasons why curing tinnitus has proved so challenging.

An estimated 30% of the global population experience this perplexing condition at least once in their lifetime. Therefore, further research about tinnitus's etiology, management, and prophylaxis is significantly valuable.

What Are The Types of Treatments Available For Tinnitus?

Although there are currently no treatments available to cure tinnitus, it can be managed in several ways. Hearing aids, cochlear implants, and wearable sound generators assist in alleviating the ringing noise so that patients may live better alongside their condition.

Tinnitus is associated with changes in mood, sleep, and concentration. Therefore, behavioral therapies play an essential role in the management of tinnitus patients. Such therapies include counseling patients about ways to live alongside their condition and initiating antidepressants to balance secondary mood disorders.

What Are Some Recent Breakthrough Clinical Trials For Tinnitus?

In recent years, scientists have made substantial strides in tinnitus research. Some of the most notable research includes the following:

2018: Using auditory-somatosensory bimodal stimulation to desynchronize brain circuitry and reduce tinnitus – Researchers at Michigan University have created a device that utilizes carefully timed sounds and electrical impulses to target touch-sensitive neurons in the brain. This treatment aims to steer damaged neural tissue involved in tinnitus back to normal function.

2020: Bimodal neuromodulation combining sound and tongue stimulation – In a study at the University of Minnesota, researchers showed that concomitant electrical stimulation of the tongue and sound stimulation effectively reduced tinnitus. Furthermore, these therapeutic outcomes could be sustained for up to 12 months.

Who Are Some Of The Key Institutions Conducting Tinnitus Clinical Trial Research?

The Lauer Tinnitus Research Center

The Lauer Tinnitus Research Center, launched in 2015 by Massachusetts General Hospital, is responsible for ground-breaking research on cochlear nerve repair, inner ear imaging, and the brain's involvement in tinnitus. Furthermore, this institution aims to address the diagnostic problems associated with tinnitus by developing testing strategies.

About The Author

Michael Gill preview

Michael Gill - B. Sc.

First Published: October 6th, 2021

Last Reviewed: February 19th, 2023