Reviewed by Michael Gill, B. Sc.
25 Pancreatic Cancer Clinical Trials Near Me

What Are Pancreatic Cancer Clinical Trials?

Pancreatic cancer clinical trials seek to test new drugs or treatment protocols for pancreatic cancer patients. If it is diagnosed early, pancreatic cancer is treatable; however, there are no discernable symptoms in the early stages, so it's rarely detected.

Symptoms only start to appear as the disease spreads to other organs, by which time it is a more advanced stage and at which time treatment options are limited.

Trials are aimed at both early detection and treatment.

What Is Pancreatic Cancer?

The pancreas organ is located behind the lower part of the stomach. The pancreas releases enzymes that aid digestion and produce and release hormones that help control the body's sugar levels.

Pancreatic cancer is observed when a metastatic tumor forms in the pancreatic cells. There are two main categories of pancreatic cancer.

  1. Pancreatic exocrine tumors.
  2. Pancreatic neuroendocrine tumors.

What Are Clinical Trials For Pancreatic Cancer?

Pancreatic cancer trials aim to test the best treatment options and give participating patients early access to cutting-edge treatment. They intend to advance progress and provide treatment with better outcomes.

Why Is Pancreatic Cancer Being Studied Through Clinical Trials?

Over 62,000 Americans are diagnosed with pancreatic cancer annually, and just under 50,000 Americans will die from the disease. It accounts for 3% of all cancers in America and 7% of all cancer deaths.

The five-year survival rate of pancreatic cancer is 10%.

Clinical trials are run to find better treatments with improved outcomes, and treatments used were the subject of previous clinical trials.

What Are The Types of Treatments Available For Pancreatic Cancer?

Current treatments for early-stage pancreatic cancer include surgery, radiation, and chemotherapy. There is no viable treatment for late-stage Pancreatic cancer.

Examples Of Current Pancreatic Treatment Trials Are

PV-10 (10% Rose Bengal Disodium) For Pancreatic Metastatic Cancer

This trial tests a single treatment injection of the drug PV-10 intended for patients with inoperable cancer.The trial will measure the drug's efficacy, safety, and the body's tolerance.

Plerixafor For Pancreatic Metastatic Cancer

The trial tests a new cancer treatment combination for safety and effectiveness in people with pancreatic cancer that has spread.

Improving Early Detection

The trial, conducted by the Pancreatic Cancer Cohort Consortium, piggybacks off the new-onset diabetes tests. The tests have shown that that 1 in 100 people with new-onset diabetes are also diagnosed with pancreatic cancer within 3 years.

The trials comprises of two imaging studies which use computerized tomography (CT) scans or magnetic resonance imaging (MRI) and their efficacy as early Detection of Pancreatic Ductal Adenocarcinoma on patients who have tested positive for hyperglycemia and diabetes.

What Are Some Recent Breakthrough Clinical Trials For Pancreatic Cancer?

Pancreatic clinical trials look to help prevent, detect, and treat pancreatic cancer,

2013: Testing The Efficacy of a second-line regimen treatment - A study, conducted by the CONKO Study Group, was performed to test the use of oxaliplatin and folinic acid-modulated fluorouracil on patients with advanced pancreatic cancer. The conclusion of the trial was that the treatments extended the duration of overall survival.

2023: Improved outcome – A study, conducted by the Perelman School of Medicine at the University of Pennsylvania, found that trial participants who received the immunotherapy nivolumab with two chemotherapy drugs, nab-paclitaxel, and gemcitabine, have an increased first-year survival rate from 35% to 57.7%.

Who Are Some Of The Key Opinion Leaders / Researchers In Pancreatic Cancer Research?

Dr. Brian Wolpin is the Director of the Gastrointestinal Cancer Center and Co-Director of the Pancreas and Biliary Tumor Center at Dana-Farber

Jason Fleming, MD: Moffitt Cancer Center in Tampa, FL

Andrea Wang-Gillam, MD Ph.D.: Siteman Cancer Center at Barnes-Jewish Hospital and Washington University School of Medicine in St. Louis, MO

About The Author

Michael Gill preview

Michael Gill - B. Sc.

First Published: October 10th, 2021

Last Reviewed: January 21st, 2023