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Chemotherapy Combinations for Advanced Pancreatic Cancer
Study Summary
This trial is testing two different combinations of drugs to see which is better at treating metastatic pancreatic cancer in older patients.
Eligibility Criteria
Inclusion Criteria
You may be eligible if you check “Yes” for the criteria belowTimeline
Treatment Details
Study Objectives
Outcome measures can provide a clearer picture of what you can expect from a treatment.Side effects data
From 2022 Phase 3 trial • 87 Patients • NCT02066181Trial Design
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- I had hepatitis C but am cured, or I'm being treated with no detectable virus.You do not live in the United States.I haven't had any cancer except for skin cancer in the last 5 years.Your white blood cell count should be at least 1,500 per microliter of blood.My kidney function is within the safe range for the study.Your bilirubin levels are within the normal range set by the hospital.I agree not to father a child during the study.My hepatitis B virus is under control with treatment.Your blood platelet count is at least 100,000 per microliter as measured within 4 weeks before joining the study.I have chronic hepatitis B but it's not under control even with treatment.My disease can be measured and I've had scans within the last 4 weeks.My kidney function is within the safe range for the trial.My cancer is not acinar cell or adenosquamous carcinoma.Your liver enzymes (AST and ALT) should not be more than 2.5 times the normal level.I am HIV positive, on treatment, and my viral load has been undetectable for the last 6 months.Your white blood cell count is at least 3,000 per microliter.You need to have a certain amount of platelets in your blood, which will be checked within 4 weeks of signing up for the study.I have hepatitis C that is either untreated or still active.I agree not to take any strong CYP3A4 affecting drugs or UGT1A1 inhibitors if assigned to the liposomal irinotecan treatment.You have severe problems with thinking or doing everyday tasks, or you have a high number of other health issues.I am HIV positive and on a treatment that includes ritonavir or cobicistat.I am able to care for myself and perform daily activities.Your total bilirubin level is within the normal range set by the hospital.Your liver enzymes (AST and ALT) should not be more than 2.5 times the normal level.I have a new, untreated metastatic pancreatic cancer but may have had surgery or therapy before.My heart is healthy enough for treatment, even with my history of heart issues or treatments.You have mild to moderate issues in any of the areas checked during the screening for older adults, and are classified as 'vulnerable'.
- Group 1: Arm A (gemcitabine, nab-paclitaxel)
- Group 2: Arm B (fluorouracil, leucovorin, liposomal irinotecan)
- No Placebo-Only Group - All patients enrolled in this study will receive some form of active treatment.
- Screening: It may take up to 3 Weeks to process to see if you qualify in this trial.
- Treatment: The duration you will receive the treatment varies.
- Follow Ups: You may be asked to continue sharing information regarding the trial for 6 Months after you stop receiving the treatment.
Frequently Asked Questions
What is the current enrollment size for this research endeavor?
"Affirmative. According to clinicaltrials.gov, this medical trial is actively seeking participants and has been since June 18th 2020; the study's details were most recently updated on June 8th 2022. 184 people across 43 sites must be enrolled in order for it to be successful."
How is Quality-of-Life Assessment typically utilized?
"Quality-of-Life Assessment is a viable therapeutic option for mesotheliomas, as well as other afflictions such as osteomalacia, hemodialysis and advanced soft tissue sarcoma."
What other trials have examined the Quality-of-Life Assessment of participants?
"Quality-of-Life Assessment has been studied since 1997 at the City of Hope Comprehensive Cancer Center, with 3216 completed clinical trials to date. Presently, 1560 active studies are being conducted in several locations across America - many out of Lancaster, Idaho."
How many geographical areas are the research participants located in?
"This clinical trial is enrolling patients in various hospitals, such as Fairfield Medical Center, Walter Knox Memorial Hospital and Kalispell Regional Medical Center. Additionally, there are 43 additional sites recruiting subjects for this study."
What risks can be associated with Quality-of-Life Evaluation?
"The safety of Quality-of-Life Assessment was assessed by our team at Power as a 2, due to the lack of clinical data demonstrating efficacy but with some evidence supporting its security."
Is there still a possibility to join this medical research experiment?
"Affirmative. The information on clinicaltrials.gov indicates this clinical trial is still recruiting participants, which was initially posted on June 18th 2020 and last amended on June 8th 2022. 184 patients need to be recruited from 43 distinct sites."
Who else is applying?
What site did they apply to?
What portion of applicants met pre-screening criteria?
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