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Key Eligibility Criteria
88 Participants Needed
Trial Details
Key Eligibility Criteria
30 Participants Needed
"I've tried several different SSRIs over the past 23 years with no luck. Some of these new treatments seem interesting... haven't tried anything like them before. I really hope that one could work."
"I have dealt with voice and vocal fold issues related to paralysis for over 12 years. This problem has negatively impacted virtually every facet of my life. I am an otherwise healthy 48 year old married father of 3 living. My youngest daughter is 12 and has never heard my real voice. I am now having breathing issues related to the paralysis as well as trouble swallowing some liquids. In my research I have seen some recent trials focused on helping people like me."
"I've been struggling with ADHD and anxiety since I was 9 years old. I'm currently 30. I really don't like how numb the medications make me feel. And especially now, that I've lost my grandma and my aunt 8 days apart, my anxiety has been even worse. So I'm trying to find something new."
"I changed my diet in 2020 and I’ve lost 95 pounds from my highest weight (283). I am 5’3”, female, and now 188. I still have a 33 BMI. I've been doing research on alternative approaches to continue my progress, which brought me here to consider clinical trials."
"My orthopedist recommended a half replacement of my right knee. I have had both hips replaced. Currently have arthritis in knee, shoulder, and thumb. I want to avoid surgery, and I'm open-minded about trying a trial before using surgery as a last resort."
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Each trial will compensate patients a different amount, but $50-100 for each visit is a fairly common range for Phase 2–4 trials (Phase 1 trials often pay substantially more). Further, most trials will cover the costs of a travel to-and-from the clinic.
After a researcher reviews your profile, they may choose to invite you in to a screening appointment, where they'll determine if you meet 100% of the eligibility requirements. If you do, you'll be sorted into one of the treatment groups, and receive your study drug. For some trials, there is a chance you'll receive a placebo. Across Tinnitus trials in Phoenix, AZ 30% of clinical trials have a placebo. Typically, you'll be required to check-in with the clinic every month or so. The average trial length in Phoenix, AZ for Tinnitus is 12 months.
Not all studies recruit healthy volunteers: usually, Phase 1 studies do. Participating as a healthy volunteer means you will go to a research facility in Phoenix, AZ several times over a few days or weeks to receive a dose of either the test treatment or a "placebo," which is a harmless substance that helps researchers compare results. You will have routine tests during these visits, and you'll be compensated for your time and travel, with the number of appointments and details varying by study.
The phase of a trial reveals what stage the drug is in to get approval for a specific condition. Phase 1 trials are the trials to collect safety data in humans. Phase 2 trials are those where the drug has some data showing safety in humans, but where further human data is needed on drug effectiveness. Phase 3 trials are in the final step before approval. The drug already has data showing both safety and effectiveness. As a general rule, Phase 3 trials are more promising than Phase 2, and Phase 2 trials are more promising than phase 1.
Clinical trials are almost always free to participants, and so do not require insurance. The only exception here are trials focused on cancer, because only a small part of the typical treatment plan is actually experimental. For these cancer trials, participants typically need insurance to cover all the non-experimental components.
Most recently, we added Neuromodulation and Listening Therapy for Tinnitus and Etanercept for Tinnitus to the Power online platform.
Yes—well over 100 clinical studies for tinnitus (from quick online surveys to device or medication trials) are recruiting worldwide. The fastest way to see what’s open is to type “tinnitus” into ClinicalTrials.gov or the WHO international registry and filter for “recruiting,” then contact the listed study team or ask your ENT/audiologist if you meet their inclusion rules. Before signing up, weigh the possible benefits against travel, time, and the chance of receiving a placebo, and be sure to read the informed-consent form carefully.
There is no single “simple trick” that reliably switches tinnitus off, but you can make it less intrusive by calming your body and giving your ears something else to focus on: try slow belly-breathing, add gentle background sound (fan, soft music, white-noise app), and relax tight neck-jaw muscles. If the ringing is new, one-sided, pulsates with your heartbeat, or comes with sudden hearing loss, see a doctor promptly; otherwise, longer-term relief often comes from structured programs such as cognitive-behavioural therapy, sound therapy, or hearing aids that address both the noise and the stress it causes.
Doctors label tinnitus “chronic” once it has persisted for about six months; after that point it rarely goes away on its own, although many people can still reduce how much it bothers them with treatment. Ringing that begins after loud noise or an ear infection usually settles within minutes, days, or at most a few weeks—so if yours lasts longer than two weeks, or is paired with new hearing loss, see an audiologist or ENT promptly to look for reversible causes and start proven coping strategies before it becomes long-term.
Yes—tinnitus can and does disappear for some people, especially when the underlying cause (e.g., ear-wax, middle-ear infection, medication side-effect, sudden hearing loss or jaw/neck problems) is found and fixed, and about 1 in 5 new cases fade on their own within a year. Even when it persists, most patients can make it much less intrusive by combining ear-focused measures (hearing aids, sound or masking devices) with brain-focused approaches like cognitive-behavioural therapy or tinnitus-retraining therapy, so the key first step is a thorough exam by an ENT/audiologist to look for reversible triggers and then choose the right management tools.
There is actually no single “drug of choice” for tinnitus—no medicine has been proven to reliably silence the ringing, and any drug use is off-label and aimed at easing related problems such as anxiety, depression, or poor sleep. Doctors first recommend non-drug strategies (hearing aids, background sound generators, cognitive-behavioral therapy) and then may trial medicines like a tricyclic antidepressant (e.g., nortriptyline), a benzodiazepine (e.g., clonazepam), or gabapentin in selected patients who are very distressed, monitoring closely for side-effects. Work with an ENT or audiologist to create a plan that addresses both the noise and its emotional impact rather than relying on a single pill.
Tinnitus can qualify as a legal disability when the ringing is severe enough to limit your ability to work or perform major life activities, but the exact test depends on the system making the decision. For Social Security (SSDI/SSI) you must show medical proof of the condition and that it stops you from “substantial gainful activity” for at least 12 months; under the ADA the same medical evidence can trigger workplace accommodations; and the VA automatically grants a 10 % rating if the tinnitus is service-connected, with higher benefits possible if it prevents employment. In every case, detailed ENT or audiology records, treatment history, and statements describing how the noise affects concentration, sleep, balance, or communication are what turn tinnitus from a symptom into a legally recognized disability.
Off-the-shelf “tinnitus ear drops” have never been shown in good studies to quiet chronic ringing, and standard prescription drops help only when they treat a reversible ear problem—think wax blockage or an outer-ear infection that is causing or amplifying the noise. If the tinnitus comes from inner-ear damage or brain pathways (the usual case), drops won’t work; proven relief instead comes from strategies like hearing aids, sound therapy, or tinnitus-focused CBT after an ENT or audiology evaluation. Seek prompt medical review if the ringing is one-sided, pulsating, or tied to sudden hearing loss, and avoid unregulated drops that can irritate the canal.
Most tinnitus is “subjective,” meaning only you can hear it, so a doctor can’t capture the sound itself—but they can still document it by showing related hearing changes on an audiogram, matching the pitch/loudness of the ringing, and scoring its impact with validated questionnaires such as the Tinnitus Handicap Inventory. This bundle of test results is usually enough for a formal diagnosis and for insurance or disability claims; only in the uncommon “objective” form can a clinician actually hear the noise through a stethoscope or microphone.
There is still no permanent cure for tinnitus, but the newest FDA-cleared treatment is Lenire, a headset that pairs tailored sounds with gentle electrical pulses to the tongue; in a 326-person randomized study, about 70 % of users had a meaningful drop in symptom scores after 12 weeks, and benefits often persisted for a year with minimal side effects. Results vary—ringing rarely disappears completely—so specialists still rely on hearing aids, sound-therapy apps, and cognitive-behavioral techniques when Lenire isn’t available or sufficient. Discuss the pros, cost, and suitability of each option with an ENT or audiologist to decide what’s realistic for you.