Barrett'S Esophagus Clinical Trials 2023

Browse 22 Barretts Esophagus Medical Studies Across 41 Cities

102 Barretts Esophagus Clinics

Clinical TrialsBarrett'S Esophagus Clinical Trials 2023
Reviewed by Michael Gill, B. Sc.
10 Barretts Esophagus Clinical Trials Near Me
Top Hospitals for Barretts Esophagus Clinical Trials
Image of Massachusetts General Hospital in Massachusetts.
Massachusetts General Hospital
Boston
4Active Trials
13All Time Trials for Barretts Esophagus
2008First Barretts Esophagus Trial
Image of University of Colorado in Colorado.
University of Colorado
Aurora
3Active Trials
5All Time Trials for Barretts Esophagus
2015First Barretts Esophagus Trial
Image of Mayo Clinic Rochester in Minnesota.
Mayo Clinic Rochester
Rochester
2Active Trials
8All Time Trials for Barretts Esophagus
2002First Barretts Esophagus Trial
Image of University Hospitals Cleveland Medical Center in Ohio.
University Hospitals Cleveland Medical Center
Cleveland
2Active Trials
3All Time Trials for Barretts Esophagus
2016First Barretts Esophagus Trial
Image of UCLA / Jonsson Comprehensive Cancer Center in California.
UCLA / Jonsson Comprehensive Cancer Center
Los Angeles
2Active Trials
2All Time Trials for Barretts Esophagus
2016First Barretts Esophagus Trial
Top Cities for Barretts Esophagus Clinical Trials
Image of Cleveland in Ohio.
Cleveland
6Active Trials
University Hospitals Cleveland Medical CenterTop Active Site
Barrett's Esophagus Clinical Trials by Phase of Trial
N/A Barrett's Esophagus Clinical Trials
15Active Barrett's Esophagus Clinical Trials
15Number of Unique Treatments
75Number of Active Locations
Intervention GroupPatients undergoing routine screening via upper endoscopy (EGD)Post-EET Surveillance Group: WATS-3D samples followed by Forceps biopsiesTethered Capsule EndomicroscopyEsophagogastroduodenoscopyIVLCM tethered capsuleCryoBalloon Focal Ablation SystemSECM capsule
Barrett's Esophagus Clinical Trials by Age Group
18+ Barrett's Esophagus Clinical Trials
20Active Barrett's Esophagus Clinical Trials
Intervention GroupPatients undergoing routine screening via upper endoscopy (EGD)Post-EET Surveillance Group: WATS-3D samples followed by Forceps biopsiesTethered Capsule EndomicroscopyEsophagogastroduodenoscopyIVLCM tethered capsuleCryoBalloon Focal Ablation SystemEMR
Most Recent Barretts Esophagus Clinical Trials
Clinical Trial
Began Recruiting Date
Phase
Arm I (OCA) for Barrett's Esophagus
7/27/2023
Phase 2
C2 Intervention for Barrett's Esophagus
4/9/2023
N/A
Enterotracker for Barrett's Esophagus
3/1/2023
Phase 1
Endoscopic Eradication Therapy for Barrett's Esophagus
1/24/2023
N/A
Esophagogastroduodenoscopy for Acid Reflux
10/25/2022
Phase < 1
Top Treatments for Barretts Esophagus Clinical Trials
Treatment Name
Active Barretts Esophagus Clinical Trials
All Time Trials for Barretts Esophagus
First Recorded Barretts Esophagus Trial
Esophagogastroduodenoscopy
2
5
2014
Intervention Group
1
1
2021
Patients undergoing routine screening via upper endoscopy (EGD)
1
1
2022
Post-EET Surveillance Group: WATS-3D samples followed by Forceps biopsies
1
1
2020
Tethered Capsule Endomicroscopy
1
1
2019
Recently Completed Studies with FDA Approved Treatments for Barretts Esophagus
Treatment
Year
Sponsor
Alginates
2017
Medical University of South Carolina

What Are Barrett's Esophagus Clinical Trials?

It is a condition that occurs when the food tube's (swallowing tube) pink lining connecting the mouth to the Esophagus gets damaged due to acid reflux. Barrett's Esophagus causes the tube lining to thicken and turn red. Symptoms of Barrett's Esophagus are acid regurgitation, sudden weight loss, difficulty swallowing, sore throat, and heartburn. An individual can be at risk to Barrett's Esophagus if they experience heartburn twice or more weekly. Heartburn is the biggest red flag.

Barrett's Esophagus clinical trials are designed to develop a comprehensive understanding of the disease and to find effective methods to diagnose and treat it.

Why Is Barrett's Esophagus Being Studied Through Clinical Trials?

Barrett's Esophagus affects 3.3 million people in the US. It is approximately 1.6 percent of the general population. Barrett's Esophagus is a GERD complication. It occurs in 10 to 20 percent of people with chronic symptoms of GERD (Gastroesophageal Reflux Disease).

Furthermore, Barrett's Esophagus increases the risk of developing esophageal adenocarcinoma. It is rare cancer. Though the risk is small, getting regular checkups with extensive esophagus biopsies is vital to check for dysplasia (precancerous cells).

Barrett's Esophagus clinical trials are essential to determine the exact cause. These clinical trials provide crucial insights to researchers much needed to find the best treatments to prevent, treat and cure the problem.   

What Are the Types of Treatments Available for Barrett's Esophagus?

The treatment for Barrett's Esophagus primarily depends on the growth of abnormal cells in the patient's Esophagus and their overall health. For example, if there is no dysplasia, then treatment for GERD is suitable for Barrett's Esophagus patients. This includes medication and some lifestyle changes. In some cases, endoscopy may be recommended for tightening the lower esophageal.

Similarly, for low and high-grade dysplasia, preferred treatments are:

  • Endoscopic resection
  • Radiofrequency ablation

What Are Some Recent Breakthrough Clinical Trials for Barrett's Esophagus?

2013: Managing Barrett's Esophagus with radiofrequency ablation – The study was conducted to determine the efficacy of radiofrequency ablation in patients with Barrett's Esophagus. It was concluded that the RFA with the HALO system provides the best treatment for successfully eradicating Barrett's Esophagus without or with dysplasia with efficacy, durability, and safety profiles.

2019: Novel Barrett's esophagus screening assays based on swallowable devices: The study identifies the need for better and cost-effective screen tests compared to endoscopy, which is expensive and inconvenient. It shows that swallowable balloons and immunohistochemistry-based assays are promising for BE detection.

Who Are Some of the Key Opinion Leaders/Researchers/Institutions Conducting Barrett's Esophagus Clinical Trial Research?

NIDDK

The National Institute of Diabetes and Digestive and Kidney Diseases is focused on conducting and supporting research to gain new knowledge and improve health. The research studies are centered around diet, nutrition, and digestive diseases.

American College of Gastroenterology

The organization is one of the top funding sources for educational programs and clinical research related to gastroenterology. These research studies help improve patient care and strengthen practitioner capabilities.

About The Author

Michael Gill preview

Michael Gill - B. Sc.

First Published: October 13th, 2021

Last Reviewed: August 7th, 2023

References1 Spechler SJ, Souza RF. Barrett's esophagus. N Engl J Med. 2014 Aug 28;371(9):836-45. doi: 10.1056/NEJMra1314704. Review. https://pubmed.ncbi.nlm.nih.gov/251628902 Spechler SJ, Souza RF. Barrett's esophagus. N Engl J Med. 2014 Aug 28;371(9):836-45. doi: 10.1056/NEJMra1314704. No abstract available. https://pubmed.ncbi.nlm.nih.gov/251628903 ASGE STANDARDS OF PRACTICE COMMITTEE, Qumseya B, Sultan S, Bain P, Jamil L, Jacobson B, Anandasabapathy S, Agrawal D, Buxbaum JL, Fishman DS, Gurudu SR, Jue TL, Kripalani S, Lee JK, Khashab MA, Naveed M, Thosani NC, Yang J, DeWitt J, Wani S; ASGE Standards of Practice Committee Chair. ASGE guideline on screening and surveillance of Barrett's esophagus. Gastrointest Endosc. 2019 Sep;90(3):335-359.e2. doi: 10.1016/j.gie.2019.05.012. https://pubmed.ncbi.nlm.nih.gov/314391274 ASGE STANDARDS OF PRACTICE COMMITTEE, Qumseya B, Sultan S, Bain P, Jamil L, Jacobson B, Anandasabapathy S, Agrawal D, Buxbaum JL, Fishman DS, Gurudu SR, Jue TL, Kripalani S, Lee JK, Khashab MA, Naveed M, Thosani NC, Yang J, DeWitt J, Wani S; ASGE Standards of Practice Committee Chair. ASGE guideline on screening and surveillance of Barrett's esophagus. Gastrointest Endosc. 2019 Sep;90(3):335-359.e2. doi: 10.1016/j.gie.2019.05.012. No abstract available. https://pubmed.ncbi.nlm.nih.gov/314391275 Vennalaganti PR, Kaul V, Wang KK, Falk GW, Shaheen NJ, Infantolino A, Johnson DA, Eisen G, Gerson LB, Smith MS, Iyer PG, Lightdale CJ, Schnoll-Sussman F, Gupta N, Gross SA, Abrams J, Haber GB, Chuttani R, Pleskow DK, Kothari S, Goldblum JR, Zhang Y, Sharma P. Increased detection of Barrett's esophagus-associated neoplasia using wide-area trans-epithelial sampling: a multicenter, prospective, randomized trial. Gastrointest Endosc. 2018 Feb;87(2):348-355. doi: 10.1016/j.gie.2017.07.039. Epub 2017 Jul 27. https://pubmed.ncbi.nlm.nih.gov/287573166 ASGE STANDARDS OF PRACTICE COMMITTEE; Qumseya B, Sultan S, Bain P, Jamil L, Jacobson B, Anandasabapathy S, Agrawal D, Buxbaum JL, Fishman DS, Gurudu SR, Jue TL, Kripalani S, Lee JK, Khashab MA, Naveed M, Thosani NC, Yang J, DeWitt J, Wani S; ASGE Standards of Practice Committee Chair. ASGE guideline on screening and surveillance of Barrett's esophagus. Gastrointest Endosc. 2019 Sep;90(3):335-359.e2. doi: 10.1016/j.gie.2019.05.012. No abstract available. https://pubmed.ncbi.nlm.nih.gov/314391277 Moinova HR, LaFramboise T, Lutterbaugh JD, Chandar AK, Dumot J, Faulx A, Brock W, De la Cruz Cabrera O, Guda K, Barnholtz-Sloan JS, Iyer PG, Canto MI, Wang JS, Shaheen NJ, Thota PN, Willis JE, Chak A, Markowitz SD. Identifying DNA methylation biomarkers for non-endoscopic detection of Barrett's esophagus. Sci Transl Med. 2018 Jan 17;10(424). pii: eaao5848. doi: 10.1126/scitranslmed.aao5848. https://pubmed.ncbi.nlm.nih.gov/293436238 Yousef F, Cardwell C, Cantwell MM, Galway K, Johnston BT, Murray L. The incidence of esophageal cancer and high-grade dysplasia in Barrett's esophagus: a systematic review and meta-analysis. Am J Epidemiol. 2008 Aug 1;168(3):237-49. doi: 10.1093/aje/kwn121. Epub 2008 Jun 12. https://pubmed.ncbi.nlm.nih.gov/185505639 Runge TM, Abrams JA, Shaheen NJ. Epidemiology of Barrett's Esophagus and Esophageal Adenocarcinoma. Gastroenterol Clin North Am. 2015 Jun;44(2):203-31. doi: 10.1016/j.gtc.2015.02.001. Epub 2015 Apr 9. https://pubmed.ncbi.nlm.nih.gov/2602119110 Dong J, Grant C, Vuong B, Nishioka N, Gao AH, Beatty M, Baldwin G, Baillargeon A, Bablouzian A, Grahmann P, Bhat N, Ryan E, Barrios A, Giddings S, Ford T, Beaulieu-Ouellet E, Hosseiny SH, Lerman I, Trasischker W, Reddy R, Singh K, Gora M, Hyun D, Queneherve L, Wallace M, Wolfsen H, Sharma P, Wang KK, Leggett CL, Poneros J, Abrams JA, Lightdale C, Leeds S, Rosenberg M, Tearney GJ. Feasibility and Safety of Tethered Capsule Endomicroscopy in Patients With Barrett's Esophagus in a Multi-Center Study. Clin Gastroenterol Hepatol. 2022 Apr;20(4):756-765.e3. doi: 10.1016/j.cgh.2021.02.008. Epub 2021 Feb 4. https://pubmed.ncbi.nlm.nih.gov/33549871
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