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Case Western Reserve University

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Cleveland, Ohio 44106

Global Leader in HIV Infection

Global Leader in Human Immunodeficiency Virus Infection

Conducts research for Ovarian Cancer

Conducts research for Lung Cancer

Conducts research for Breast Cancer

631 reported clinical trials

65 medical researchers

Photo of Case Western Reserve University in ClevelandPhoto of Case Western Reserve University in ClevelandPhoto of Case Western Reserve University in Cleveland

Summary

Case Western Reserve University is a medical facility located in Cleveland, Ohio. This center is recognized for care of HIV Infection, Human Immunodeficiency Virus Infection, Ovarian Cancer, Lung Cancer, Breast Cancer and other specialties. Case Western Reserve University is involved with conducting 631 clinical trials across 886 conditions. There are 65 research doctors associated with this hospital, such as Duncan S. Stearns, Amy Armstrong, MD, Pedro M. Barata, and Afshin Dowlati, MD.

Area of expertise

1

HIV Infection

Global Leader

Case Western Reserve University has run 81 trials for HIV Infection. Some of their research focus areas include:

t(9;22) positive
t(1;19) positive
t(4;11) positive
2

Human Immunodeficiency Virus Infection

Global Leader

Case Western Reserve University has run 76 trials for Human Immunodeficiency Virus Infection.

Top PIs

Clinical Trials running at Case Western Reserve University

Lung Cancer

Ovarian Cancer

Skin Cancer

Breast Cancer

Cancer

Kidney Cancer

Oropharyngeal Carcinoma

Breast cancer

Endometrial Cancer

Small Cell Lung Cancer

Image of trial facility.

Osimertinib + Bevacizumab

for Lung Cancer

This phase III trial compares the effect of bevacizumab and osimertinib combination vs. osimertinib alone for the treatment of non-small cell lung cancer that has spread outside of the lungs (stage IIIB-IV) and has a change (mutation) in a gene called EGFR. The EGFR protein is involved in cell signaling pathways that control cell division and survival. Sometimes, mutations in the EGFR gene cause EGFR proteins to be made in higher than normal amounts on some types of cancer cells. This causes cancer cells to divide more rapidly. Osimertinib may stop the growth of tumor cells by blocking EGFR that is needed for cell growth in this type of cancer. Bevacizumab is in a class of medications called antiangiogenic agents. It works by stopping the formation of blood vessels that bring oxygen and nutrients to tumor. This may slow the growth and spread of tumor. Giving osimertinib with bevacizumab may control cancer for longer and help patients live longer as compared to osimertinib alone.

Recruiting

2 awards

Phase 3

31 criteria

Image of trial facility.

High-Dose Radiation + Chemotherapy and Immunotherapy

for Non-Small Cell Lung Cancer

This trial tests whether adding a precise form of radiation therapy to the usual treatment improves outcomes for patients with advanced lung cancer that can't be operated on. The goal is to see if this combination helps patients live longer and prevents cancer from worsening. This form of radiation therapy has shown promise in improving survival rates in patients with various stages of lung cancer.

Recruiting

2 awards

Phase 3

14 criteria

Image of trial facility.

Chemotherapy + Immunotherapy vs. Immunotherapy

for Advanced Lung Cancer

This phase III trial compares the effect of adding chemotherapy to immunotherapy (pembrolizumab) versus immunotherapy alone in treating patients with stage IIIB-IV lung cancer. Immunotherapy with monoclonal antibodies, such as pembrolizumab, may help the body's immune system attack the cancer, and may interfere with the ability of tumor cells to grow and spread. Chemotherapy drugs work in different ways to stop the growth of tumor cells, either by killing the cells, by stopping them from dividing, or by stopping them from spreading. Giving pembrolizumab and chemotherapy may help stabilize lung cancer.

Recruiting

2 awards

Phase 3

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