Rifaximin for Dementia
(RIDE Trial)
What You Need to Know Before You Apply
What is the purpose of this trial?
Using a new formulation of rifaximin, a non-absorbable antibiotic, to test if it can affect microbes in the gut of patients with dementia favorably.
Will I have to stop taking my current medications?
The trial does not specify if you must stop all current medications, but you cannot take medications that interact with Rifaximin. If you are on P-glycoprotein (P-gp) inhibitors, you can continue them, but you need to discuss this with the investigator.
Is rifaximin safe for humans?
What data supports the effectiveness of the drug Rifaximin SSD for dementia?
Who Is on the Research Team?
Jasmohan Bajaj
Principal Investigator
Richmond VA Medical Center
Are You a Good Fit for This Trial?
This trial is for individuals aged 65 or older with mild to moderate Alzheimer's Disease or Vascular Dementia. Participants must be able to consent (or have a legal guardian who can), speak English, and live in the community with a caregiver available.Inclusion Criteria
Exclusion Criteria
Timeline for a Trial Participant
Screening
Participants are screened for eligibility to participate in the trial
Treatment
Participants receive Rifaximin SSD or placebo in a single-blind, placebo-controlled trial to assess changes in gut microbiota and systemic biomarkers
Follow-up
Participants are monitored for safety and effectiveness after treatment
What Are the Treatments Tested in This Trial?
Interventions
- Rifaximin SSD
Find a Clinic Near You
Who Is Running the Clinical Trial?
Jasmohan Bajaj
Lead Sponsor
Bausch Health Companies, INC.
Collaborator
Bausch Health Americas, Inc.
Industry Sponsor
Dr. Jonathan Sadeh
Bausch Health Americas, Inc.
Chief Medical Officer
MD from Mount Sinai School of Medicine, MSc in Clinical Research from Harvard Medical School
Thomas J. Appio
Bausch Health Americas, Inc.
Chief Executive Officer since 2021
Bachelor's degree in Biology from Rutgers University