Quick Renal MRI for Pediatric Kidney Disease

Overseen By Shannon Cannon, MD

Age: < 65

Sex: Any

Trial Phase: Academic

Sponsor: University of Wisconsin, Madison

Disqualifiers: No pyuria, Negative urine culture, MRI contraindications, others

No Placebo Group All trial participants will receive the active study treatment (no placebo)

Compensation: Varies

Number of Visits: 4

100 Participants Needed

What You Need to Know Before You Apply

What is the purpose of this trial?

This trial tests a new, quick MRI method to detect kidney infections and scarring in children with urinary tract issues. It aims to determine if this quick MRI matches the accuracy of the current standard test, which requires an injection and radiation. The goal is to make testing easier and less stressful for children with chronic kidney problems. The trial seeks participants who have experienced more than one urinary tract infection (UTI) in the past year or are currently hospitalized due to a UTI and undergoing the standard kidney scan. As an unphased trial, this study offers an opportunity to contribute to research that could enhance diagnostic methods for children.

Will I have to stop taking my current medications?

The trial information does not specify whether you need to stop taking your current medications. It's best to discuss this with the trial coordinators or your doctor.

What prior data suggests that this imaging method is safe for children?

Research shows that the quick renal MRI is being tested as a safer method for imaging children's kidneys. Unlike some other techniques, this MRI doesn't require injections, sedation, or radiation, reducing risks for kids and likely resulting in fewer side effects.

Participants in these studies generally find MRIs manageable, as they only need to lie still during the scan. However, some may feel uncomfortable inside the machine. This MRI functions like regular MRIs, which are generally safe unless metal in the body could interfere with the scan. Informing the medical team about any metal implants before the MRI is crucial.

Overall, researchers are examining the quick renal MRI to simplify and enhance the safety of imaging for children with kidney issues. ^{1 2 3 4 5}

Why are researchers excited about this trial?

Researchers are excited about the Quick Renal MRI for pediatric kidney disease because it promises a faster and safer alternative to traditional imaging methods like DMSA scans. Unlike conventional scans, which involve radiation exposure and can take a longer time, Quick MRI uses magnetic resonance imaging to capture detailed kidney images without radiation. This method is particularly beneficial for children because it reduces their exposure to potentially harmful radiation and makes the imaging process quicker and more comfortable. If proven effective, Quick MRI could revolutionize how we diagnose and monitor kidney disease in young patients.

What evidence suggests that the quick renal MRI is effective for detecting acute renal infections and scars in pediatric kidney disease?

This trial will evaluate the Quick Renal MRI as a potential alternative to the traditional DMSA kidney scan for detecting infections and scarring in children's kidneys. Studies have shown that a quick kidney MRI could be a promising option, as it avoids injections, sedation, and radiation, making it safer and more comfortable for children. Early findings suggest that the quick kidney MRI might match the accuracy of the DMSA scan. This could simplify care for children with long-term kidney problems. Although more research is needed, the early results are encouraging. ^{1 2 3 6 7}

Who Is on the Research Team?

Shannon Cannon, MD

Principal Investigator

University of Wisconsin, Madison

Are You a Good Fit for This Trial?

This trial is for children and young adults (0-21 years) with kidney conditions like infections or scarring, who are already getting DMSA scans as part of their care. It's not for those uncomfortable with MRI, without signs of infection in urine tests, negative urine cultures, or who can't have an MRI due to other medical reasons.

Inclusion Criteria

I am in the hospital for a fever and kidney infection, getting a special kidney scan.

I have had more than one urinary tract infection in the last year.

You are currently having DMSA scans as part of your regular medical care.

Exclusion Criteria

Your urine test does not show any signs of infection.

I am not comfortable with undergoing a Quick MRI.

You cannot have an MRI for medical reasons.

Timeline for a Trial Participant

Screening

Participants are screened for eligibility to participate in the trial

1-2 weeks

Aim 1: Acute Pyelonephritis Evaluation

Inpatients with acute pyelonephritis undergo a clinical DMSA scan and quick MRI within one week of each other.

1 week

2 visits (inpatient)

Aim 2: Renal Scarring Evaluation

Patients with renal scarring undergo a clinical DMSA scan and quick MRI within 6 months of each other.

6 months

2 visits (outpatient)

Follow-up

Participants are monitored for safety and effectiveness after imaging procedures.

4 weeks

What Are the Treatments Tested in This Trial?

Interventions

• Quick MRI

Trial Overview The study is testing a new 'quick renal MRI' method against the standard DMSA scan used to detect kidney infections and scarring. The goal is to see if this quick MRI can be a faster, safer option that doesn't need injections, sedation, or radiation.

How Is the Trial Designed?

Group I: DMSA/Quick MRI Experimental Treatment 1 Intervention

All participants will go through DMSA and Quick MRI scan to help determine the validity of the Quick Renal MRI in pediatric kidney disease.

Who Is Running the Clinical Trial?

University of Wisconsin, Madison

Lead Sponsor

Trials

1,249

Recruited

3,255,000+

Citations

1. clinicaltrials.gov clinicaltrials.gov/study/NCT03959163

The Validity of the Quick Renal MRI in Pediatric Kidney ... Findings from these studies will provide preliminary data and rationale for a multi-centered study to further test this new technology.

2. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov/articles/PMC12159281/

Diffusion Tensor Imaging (DTI) as a Non‐Invasive Tool for ... Our study demonstrates the feasibility of using diffusion tensor imaging (DTI) to evaluate pediatric kidney transplants.

3. cdn.clinicaltrials.gov cdn.clinicaltrials.gov/large-docs/63/NCT03959163/Prot_SAP_000.pdf

The Validity of the Quick Renal MRI in Pediatric Kidney ... Data from eligible patients' medical records will be entered into an ... • A lack of efficacy of the Quick MRI to accurately image renal scarring.

4. withpower.com withpower.com/trial/quick-renal-mri-for-pediatric-kidney-disease-ccbf0

Quick Renal MRI for Pediatric Kidney Disease This proposal hypothesizes that the quick renal MRI has high validity compared to current radiologic standard for renal infection and scarring, the ...

5. kireports.org kireports.org/article/S2468-0249(24)01924-7/pdf

Multimodal Magnetic Resonance Imaging Assessments of ... In this initial study, patients with ARPKD (n ¼ 13, 5 males and 8 females, aged 6–22 years) were evaluated both as a single cohort as well as 2 ...

6. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov/articles/PMC6993529/

State-of-the-Art Renal Imaging in Children - PMC We review common practice and novel renal imaging techniques in ultrasonography and MRI as well as 3D printing for children with kidney and urinary tract ...

7. ncbi.nlm.nih.gov ncbi.nlm.nih.gov/books/NBK551669/

Magnetic Resonance Imaging Contraindications - NCBI - NIH Patients should be asked about the presence of any foreign substances or materials that could interfere with the MRI. If a patient has a device ...