Healthy Lifestyle Intervention for Bone Health
(LIMB-Q Trial)
Trial Summary
Do I need to stop my current medications for the trial?
The trial requires that you do not use certain bone-acting drugs, like estrogen or bisphosphonates, and weight loss drugs. If you're on these, you may need to stop them to participate.
What data supports the effectiveness of the treatment Healthy Lifestyle Intervention for Bone Health?
Is the Healthy Lifestyle Intervention generally safe for humans?
How is the Healthy Lifestyle Intervention treatment for bone health different from other treatments?
The Healthy Lifestyle Intervention treatment is unique because it focuses on improving bone health through lifestyle changes like diet and physical activity, rather than using medications. This approach is similar to interventions used for weight loss and cardiovascular health, emphasizing behavior change and counseling to promote long-term health improvements.247810
What is the purpose of this trial?
Obese older adults will be randomized to participate in either healthy lifestyle intervention or behavioral diet and exercise intervention for one year. This study aims to determine the effects of Lifestyle intervention on bone microarchitecture, bone strength, bone material properties, and the mechanism behind it.
Research Team
Dennis T Villareal, MD
Principal Investigator
Baylor College of Medicine
Eligibility Criteria
This trial is for obese older adults aged 65-85 with a BMI of 30-40 who are sedentary and have had a stable body weight in the last six months. It's not for those with osteoporosis, severe diseases that limit exercise, cognitive impairments, uncontrolled hypertension, recent cancer (except skin), or on certain medications.Inclusion Criteria
Exclusion Criteria
Timeline
Screening
Participants are screened for eligibility to participate in the trial
Treatment
Participants are randomized to either a healthy lifestyle intervention or a behavioral diet and exercise intervention for one year
Follow-up
Participants are monitored for changes in bone quality, strength, and other health metrics after the intervention
Treatment Details
Interventions
- Healthy Lifestyle Intervention
- Lifestyle Intervention
Find a Clinic Near You
Who Is Running the Clinical Trial?
Baylor College of Medicine
Lead Sponsor
National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
Collaborator
Michael E. DeBakey VA Medical Center
Collaborator
Biomedical Research Institute of New Mexico
Collaborator