Psychotherapy for Postpartum Depression
What You Need to Know Before You Apply
What is the purpose of this trial?
This trial explores the effectiveness of two therapies—Cognitive Behavioral Therapy (CBT) and Interpersonal Therapy (IPT)—in treating postpartum depression (PPD) in mothers with babies in the Neonatal Intensive Care Unit (NICU). It compares a 4-week session of each therapy individually with an 8-week session that combines both therapies. This trial suits mothers with an infant in the NICU who are experiencing postpartum depression. As an unphased trial, it provides a unique opportunity for mothers to explore new therapeutic approaches tailored to their specific needs.
Will I have to stop taking my current medications?
The trial information does not specify whether you need to stop taking your current medications. It might be best to discuss this with the trial coordinators or your doctor.
Is there any evidence suggesting that this trial's treatments are likely to be safe?
Research shows that both Cognitive Behavioral Therapy (CBT) and Interpersonal Therapy (IPT) are generally safe for treating postpartum depression. Studies on CBT have found it well-tolerated, with many women experiencing symptom relief and few side effects. For instance, online and app-based CBT programs have effectively helped women with postpartum depression, indicating it is a safe option.
Similarly, IPT has a strong safety record. Research indicates that women who undergo IPT for postpartum depression often see significant improvements in their symptoms. Specifically, women receiving IPT are much less likely to remain clinically depressed. These findings suggest that IPT is also well-tolerated, with no major negative effects reported.
In summary, both CBT and IPT are considered safe and effective for treating postpartum depression, with studies supporting their use without significant safety concerns.12345Why are researchers excited about this trial?
Researchers are excited about these treatments for postpartum depression because they combine Cognitive Behavioral Therapy (CBT) and Interpersonal Therapy (IPT) in a novel way. Unlike standard treatments that often rely solely on medication or a single type of therapy, this approach uses a cross-over method, allowing participants to benefit from both CBT and IPT. This unique combination may provide more comprehensive support by addressing both cognitive patterns and social dynamics, potentially leading to better outcomes for new mothers. Plus, the use of telehealth makes these therapies more accessible, offering flexibility for participants to receive support from the comfort of their homes.
What evidence suggests that this trial's treatments could be effective for postpartum depression?
Research has shown that Cognitive Behavioral Therapy (CBT), one of the therapies under study in this trial, effectively treats postpartum depression (PPD). One study found that even a single day of online CBT improved PPD symptoms in mothers. Traditional CBT has also proven effective in reducing depression, anxiety, and stress in new mothers.
Interpersonal Therapy (IPT), the other therapy under study, also benefits those with PPD. Studies indicate that women who received IPT were 4.5 times less likely to remain clinically depressed. IPT effectively reduces depressive symptoms, enhancing mood and well-being in postpartum women.
Both therapies have strong evidence supporting their effectiveness for PPD, making them promising options for those experiencing this condition. Participants in this trial will receive both therapies in a cross-over design to evaluate their effectiveness.12367Who Is on the Research Team?
Yeraz Markarian, PhD
Principal Investigator
Hackensack Meridian Health
Are You a Good Fit for This Trial?
This trial is for mothers with Postpartum Depression (PPD) whose newborns are in the Neonatal Intensive Care Unit (NICU). Participants should be experiencing PPD symptoms that affect daily life. The study seeks to include those who have not yet started psychotherapy treatment.Inclusion Criteria
Exclusion Criteria
Timeline for a Trial Participant
Screening
Participants are screened for eligibility to participate in the trial
Initial Treatment
Participants receive either a 4-week CBT or IPT intervention
Crossover Treatment
Participants cross over to the second 4-week intervention (IPT or CBT)
Follow-up
Participants are monitored for safety and effectiveness after treatment
What Are the Treatments Tested in This Trial?
Interventions
- Cognitive Behavioral Therapy (CBT)
- Interpersonal Therapy (IPT)
Trial Overview
The OBWELL trial tests Cognitive Behavioral Therapy (CBT) and Interpersonal Therapy (IPT) delivered via telehealth over 4 weeks. It compares their effectiveness separately and explores if an 8-week sequential combination of both therapies offers greater benefits for treating PPD in NICU mothers.
How Is the Trial Designed?
2
Treatment groups
Experimental Treatment
After the first 4-week of IPT intervention , participants will be administered the Peri-Intervention (Week 4) Assessment - which consists of the EPDS, Social Determinants of Health, and the Risk Factor questionnaire - and then "cross-over" to the second 4-week of CBT intervention.
After the first 4-week of CBT intervention , participants will be administered the Peri-Intervention (Week 4) Assessment - which consists of the EPDS, Social Determinants of Health, and the Risk Factor questionnaire - and then "cross-over" to the second 4-week of IPT intervention.
Find a Clinic Near You
Who Is Running the Clinical Trial?
Hackensack Meridian Health
Lead Sponsor
New Jersey Health Foundation
Collaborator
Citations
The Effects of Online Cognitive Behavioral Therapy on ...
Background/Objectives: Postpartum depression seriously affects the safety and health of mothers and children. Online cognitive behavioral therapy is ...
Home | SAMHSA - Substance Abuse and Mental Health ...
SAMHSA leads efforts to advance behavioral health across the U.S., offering resources for mental health, substance use, and community well-being.
Effectiveness of cognitive behavioral therapy for perinatal ...
Overall, CBT is effective for perinatal maternal depression, anxiety and stress. · CBT-only is effective for perinatal depression in low-income women. · Partner- ...
4.
bmcpsychiatry.biomedcentral.com
bmcpsychiatry.biomedcentral.com/articles/10.1186/s12888-023-04547-9Effectiveness of cognitive behavioural therapy-based ...
Although existing evidence suggests cognitive behavioral therapy (CBT) based interventions are effective for perinatal depression, less is known ...
Effect of Online 1-Day Cognitive Behavioral Therapy ...
In this randomized clinical trial of 403 mothers, online 1-day CBT-based workshops led to clinically and statistically significant improvements in PPD and ...
Effectiveness of an app-based cognitive behavioral therapy ...
The objective of this study was to examine the effect of mobile phone applications (App) based cognitive behavioral therapy (CBT) on postpartum depression.
Internet Cognitive Behavioral Therapy for Women With ...
Background: There are few published controlled trials examining the efficacy of Internet-based treatment for postnatal depression (PND) and ...
Other People Viewed
By Subject
By Trial
Related Searches
Unbiased Results
We believe in providing patients with all the options.
Your Data Stays Your Data
We only share your information with the clinical trials you're trying to access.
Verified Trials Only
All of our trials are run by licensed doctors, researchers, and healthcare companies.