Mannose Supplementation for Healthy Individuals

Overseen By Elisa Lin

Age: 18+

Sex: Any

Trial Phase: Academic

Sponsor: University of Texas Southwestern Medical Center

Must not be taking: Medications, Supplements

Disqualifiers: Medical diagnosis, Pregnancy, others

No Placebo Group All trial participants will receive the active study treatment (no placebo)

Compensation: Varies

Number of Visits: 2

Duration: 1 week

What You Need to Know Before You Apply

What is the purpose of this trial?

This trial explores how mannose, a type of sugar, affects proteins in healthy people. Researchers aim to determine if mannose helps proteins form better and faster or alters protein structures beneficially. The trial is open to healthy individuals not taking any medications or supplements and willing to give consent. As an unphased trial, participants have the unique opportunity to contribute to foundational research that could lead to new scientific insights.

Do I have to stop taking my current medications to join the trial?

Yes, you must stop taking any medications or nutritional supplements to participate in this trial.

Is there any evidence suggesting that mannose supplementation is safe for healthy individuals?

Research has shown that D-mannose is likely safe for most adults when used for up to six months. However, some people might experience side effects such as diarrhea, nausea, and bloating. A rare allergic reaction similar to serum sickness has also been reported in connection with D-mannose. Although uncommon, this underscores the need for further research to better understand potential side effects. Overall, many tolerate D-mannose well, but awareness of possible reactions is important. ^{1 2 3 4 5}

Why are researchers excited about this trial?

Mannose supplementation is unique because it explores the potential benefits of mannose, a simple sugar, for improving overall health in people without specific health conditions. Unlike standard treatments that target specific diseases with medications, mannose could offer a natural way to support bodily functions. Researchers are excited about its potential to promote a healthy metabolism and possibly support immune function, setting it apart from conventional health supplements due to its novel approach and natural origin.

What evidence suggests that mannose supplementation might be effective for healthy individuals?

Research suggests that mannose might enhance protein function by adding sugar molecules, potentially increasing stability. Some studies have examined mannose for preventing urinary tract infections (UTIs) but found it ineffective. This trial focuses on how mannose supplementation might alter protein structure in healthy individuals, possibly increasing stability or improving production. Strong clinical evidence on these effects in healthy individuals is lacking, so further research is necessary to confirm these ideas. ^{6 7 8 9 10}

Who Is on the Research Team?

Jeffrey SoRelle, M.D.

Principal Investigator

UT Southwestern Medical Center

Are You a Good Fit for This Trial?

This trial is for healthy adults over 18 who aren't on any medications or supplements. Participants must not have known medical conditions and agree to provide informed consent.

Inclusion Criteria

Agree to the study and provide informed consent

I am not taking any medications or supplements.

I do not have any known medical conditions.

Exclusion Criteria

I am under 18 years old.

I have a known medical condition or am pregnant.

Do not provide consent

Timeline for a Trial Participant

Screening

Participants are screened for eligibility to participate in the trial

1-2 weeks

Treatment

Participants take mannose supplements for 1 week

1 week

2 visits (in-person)

Follow-up

Participants are monitored for changes in glycan structure and protein levels

4 weeks

What Are the Treatments Tested in This Trial?

Interventions

• Mannose

Trial Overview The study is testing the effects of mannose, a type of sugar, as a supplement in healthy individuals. Researchers will look at changes in protein levels and structures in blood samples to see if mannose improves protein stability or affects glycosylation—the process where sugars attach to proteins.

How Is the Trial Designed?

Group I: Mannose supplementation Experimental Treatment 1 Intervention

Mannose supplementation will be given and subjects will be studied at baseline and after treatment.

Who Is Running the Clinical Trial?

University of Texas Southwestern Medical Center

Lead Sponsor

Trials

1,102

Recruited

1,077,000+

Citations

1. evidence.nihr.ac.uk evidence.nihr.ac.uk/alert/d-mannose-does-not-prevent-urinary-tract-infections-utis/

D-mannose does not prevent urinary tract infections (UTIs) The study suggests that D-mannose is not effective at preventing urinary tract infections (UTIs) in women who have frequent infections.

2. sciencedirect.com sciencedirect.com/science/article/pii/S2214426920300926

Clinical outcomes in an adult patient with mannose ... Clinical features include hyperinsulinaemic hypoglycaemia, protein losing enteropathy, hepatomegaly and hepatic fibrosis, digestive symptoms and coagulation ...

3. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov/articles/PMC9788503/

The Clinical Trial Outcomes of Cranberry, D-Mannose and ... Although D-mannose was successful at reducing the number of UTIs, there were insufficient trials with a sufficient sample size to validate this ...

4. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov/articles/PMC12582996/

D-Mannose for prevention of recurrent urinary tract infection in ... Prophylaxis with D-mannose did not cause any difference in the risk of recurrent UTI during follow-up and adverse events in adult women. Fewer ...

5. jamanetwork.com jamanetwork.com/journals/jamainternalmedicine/fullarticle/2817488

d-Mannose for Prevention of Recurrent Urinary Tract ... Primary outcome data were available for 583 participants (97.5%). The proportion contacting ambulatory care with a clinically suspected UTI was ...

6. webmd.com webmd.com/vitamins/ai/ingredientmono-1114/d-mannose

D-Mannose - Uses, Side Effects and More When taken by mouth: D-mannose is possibly safe for most adults when taken for up to 6 months. It can cause diarrhea and nausea. There isn't enough reliable ...

7. innophos.com innophos.com/-/media/innophos-com/customer-center-files/nutrition/public/unique/002/d-mannose-sds.pdf

SAFETY DATA SHEET D-Mannose Ecotoxicity. Not regarded as dangerous for the environment. However, large or frequent spills may have hazardous effects on the environment.

8. chemicalbook.com chemicalbook.com/article/adverse-effect-of-d-mannose.htm

Adverse effect of D-mannose Adverse effect. Common side effects of D-mannose include bloating, loose stools, and diarrhea. As D-mannose is excreted from the body in urine, ...

9. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov/articles/PMC11193288/

Serum sickness-like reaction to D-mannose supplement This case report describes the first documented case of serum sickness-like reaction caused by UQora (active ingredient D-mannose).

10. medicalnewstoday.com medicalnewstoday.com/articles/323938

D-mannose: Uses, UTIs, benefits, and risks More research can help provide accurate information about the potential side effects and risks of D-mannose, and confirm an appropriate dosage.