Mannose Supplementation for Healthy Individuals

Overseen By Elisa Lin

Age: 18+

Sex: Any

Trial Phase: Academic

Sponsor: University of Texas Southwestern Medical Center

Must not be taking: Medications, Supplements

Disqualifiers: Medical diagnosis, Pregnancy, others

No Placebo Group All trial participants will receive the active study treatment (no placebo)

Compensation: Varies

Number of Visits: 2

Duration: 1 week

6 Participants Needed

Trial Summary

What is the purpose of this trial?

The purpose of our study is to investigate the effects of supplemental mannose on sera of humans who are healthy. We will perform proteomics studies to elucidate changes to glycan structure and protein level changes. We hypothesize that we may find that mannose supplies more properly glycosylated protein substrate and helps expedite protein synthesis, that excess mannose leads to alternative glycan structures which confer improved stability, or that there are new sites that become glycosylated after mannose supplementation.

Research Team

Jeffrey SoRelle, M.D.

Principal Investigator

UT Southwestern Medical Center

Eligibility Criteria

This trial is for healthy adults over 18 who aren't on any medications or supplements. Participants must not have known medical conditions and agree to provide informed consent.

Inclusion Criteria

Agree to the study and provide informed consent

I am not taking any medications or supplements.

I do not have any known medical conditions.

Exclusion Criteria

I am under 18 years old.

I have a known medical condition or am pregnant.

I am currently taking medications or nutritional supplements.

Timeline

Screening

Participants are screened for eligibility to participate in the trial

1-2 weeks

Treatment

Participants take mannose supplements for 1 week

1 week

2 visits (in-person)

Follow-up

Participants are monitored for changes in glycan structure and protein levels

4 weeks

Treatment Details

Interventions

• Mannose

Trial Overview The study is testing the effects of mannose, a type of sugar, as a supplement in healthy individuals. Researchers will look at changes in protein levels and structures in blood samples to see if mannose improves protein stability or affects glycosylation—the process where sugars attach to proteins.

Participant Groups

Group I: Mannose supplementation Experimental Treatment 1 Intervention

Mannose supplementation will be given and subjects will be studied at baseline and after treatment.

Who Is Running the Clinical Trial?

University of Texas Southwestern Medical Center

Lead Sponsor

Trials

1,102

Recruited

1,077,000+