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Imaging

4DCT Imaging for Wrist Ligament Injuries (4DCT Trial)

N/A
Waitlist Available
Led By Kristin D. Zhao, Ph.D.
Research Sponsored by Kristin Zhao, PhD
Eligibility Criteria Checklist
Specific guidelines that determine who can or cannot participate in a clinical trial
Must have
Unilateral scapholunate instability
Point tenderness over the dorsal aspect of the scapholunate joint
Timeline
Screening 3 weeks
Treatment Varies
Follow Up 2 years
Awards & highlights

4DCT Trial Summary

This trial will test whether a new, non-invasive imaging technique can replace current invasive diagnostic tests for wrist ligament injuries.

Who is the study for?
This trial is for adults aged 18-60 with suspected scapholunate ligament injuries in the wrist, indicated by specific signs like a positive Watson shift sign or tenderness over the joint. It's not for those with rheumatological conditions, congenital malformations of the wrist/forearm, diagnosed osteoarthritis, or if they can't be positioned properly in a scanner.Check my eligibility
What is being tested?
The study is testing whether 4DCT imaging can effectively diagnose wrist ligament injuries and potentially replace more invasive tests. Participants will undergo this advanced imaging technique to assess its accuracy and usefulness.See study design
What are the potential side effects?
Since 4DCT is an imaging procedure similar to regular CT scans but with movement captured, side effects might include exposure to radiation. However, there are typically no direct side effects from the scan itself.

4DCT Trial Eligibility Criteria

Inclusion Criteria

You may be eligible if you check “Yes” for the criteria below
Select...
I have instability in one of my wrist's key ligaments.
Select...
I have sharp pain on the back of my wrist over a specific joint.

4DCT Trial Timeline

Screening ~ 3 weeks
Treatment ~ Varies
Follow Up ~2 years
This trial's timeline: 3 weeks for screening, Varies for treatment, and 2 years for reporting.

Treatment Details

Study Objectives

Outcome measures can provide a clearer picture of what you can expect from a treatment.
Primary outcome measures
Equivalency of 4DCT-based treatment plan to arthroscopic-based treatment plan, determined by surgeon evaluation and comparison, VAS, and PRWE.
Secondary outcome measures
Subject perception of surgical outcome

4DCT Trial Design

1Treatment groups
Experimental Treatment
Group I: SLIL InjuryExperimental Treatment1 Intervention
Surgical interventions for all subjects will be determined based on combined findings of both 4DCT and standard arthroscopy.
Treatment
First Studied
Drug Approval Stage
How many patients have taken this drug
4DCT
2022
N/A
~40

Find a Location

Who is running the clinical trial?

Kristin Zhao, PhDLead Sponsor
6 Previous Clinical Trials
45 Total Patients Enrolled
National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS)NIH
483 Previous Clinical Trials
1,086,880 Total Patients Enrolled
Kristin D. Zhao, Ph.D.Principal InvestigatorMayo Clinic
7 Previous Clinical Trials
98 Total Patients Enrolled

Media Library

4DCT (Imaging) Clinical Trial Eligibility Overview. Trial Name: NCT03193996 — N/A
Scapholunate Ligament Injury Research Study Groups: SLIL Injury
Scapholunate Ligament Injury Clinical Trial 2023: 4DCT Highlights & Side Effects. Trial Name: NCT03193996 — N/A
4DCT (Imaging) 2023 Treatment Timeline for Medical Study. Trial Name: NCT03193996 — N/A

Frequently Asked Questions

These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.

Is there an opportunity for me to take part in this research?

"This clinical trial is accepting 60 people aged between 18 and 60 who exhibit a scapholunate interosseous ligament injury. Additionally, they must demonstrate the following criteria: Watson shift sign (Watson et al., J Hand Surg Am, 1988; 13:657-60); point tenderness on the dorsal side of the scapholunate joint; unilateral instability of the said joint."

Answered by AI

Are there any available slots for participants in this research endeavor?

"According to clinicaltrials.gov, this experimental study is no longer enlisting participants. It was initially posted on October 23rd 2017 and its details were last modified on February 25th 2022. Despite the conclusion of recruitment for this one trial, there are presently 739 other trials actively recruiting patients from around the world."

Answered by AI

Does this research endeavor include older participants over thirty years of age?

"The inclusion criteria for this medical trial stipulates that all participants must be aged 18 or older, and under 60."

Answered by AI
Recent research and studies
clinicaltrials.govStudy
4DCT Imaging for Improved Diagnosis and Treatment of Wrist Ligament Injuries
Kristin Zhao, PhD 2017. "4DCT Imaging for Improved Diagnosis and Treatment of Wrist Ligament Injuries". ClinicalTrials.gov. https://clinicaltrials.gov/ct2/show/NCT03193996.
~8 spots leftby Apr 2025
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