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Device

Low Intensity Focused Ultrasound Device for Traumatic Brain Injury (LIFUP Trial)

N/A
Waitlist Available
Led By Martin M Monti, Prof
Research Sponsored by University of California, Los Angeles
Eligibility Criteria Checklist
Specific guidelines that determine who can or cannot participate in a clinical trial
Must have
Be older than 18 years old
Timeline
Screening 3 weeks
Treatment Varies
Follow Up day 16 (+/-3) and day 180 (+/-15)
Awards & highlights

LIFUP Trial Summary

This trial is testing whether focused ultrasound pulsation of the thalamus can help patients with disorders of consciousness.

Eligible Conditions
  • Traumatic Brain Injury
  • Consciousness Disorders

LIFUP Trial Timeline

Screening ~ 3 weeks
Treatment ~ Varies
Follow Up ~day 16 (+/-3) and day 180 (+/-15)
This trial's timeline: 3 weeks for screening, Varies for treatment, and day 16 (+/-3) and day 180 (+/-15) for reporting.

Treatment Details

Study Objectives

Outcome measures can provide a clearer picture of what you can expect from a treatment.
Primary outcome measures
Number of Participants With (Severe) Adverse Events
Number of Voxels in Which the Functional Magnetic Resonance Imaging (fMRI) Signal is Significantly Associated to LIFUP (Session 2)
Number of Voxels in Which the Functional Magnetic Resonance Imaging (fMRI) Signal is Significantly Associated to LIFUP Across the Whole Group (Session 1)
Secondary outcome measures
Coma Recovery Scale Revised (CRS-R)
Glasgow Outcome Scale-Extended (GOS-E)

LIFUP Trial Design

1Treatment groups
Experimental Treatment
Group I: Low Intensity Focused Ultrasound DeviceExperimental Treatment1 Intervention
15 acute DOC patients, 15 chronic DOC patients

Find a Location

Who is running the clinical trial?

University of California, Los AngelesLead Sponsor
1,528 Previous Clinical Trials
10,276,828 Total Patients Enrolled
Tiny Blue Dot FoundationUNKNOWN
4 Previous Clinical Trials
368 Total Patients Enrolled
The Dana FoundationOTHER
17 Previous Clinical Trials
961 Total Patients Enrolled

Frequently Asked Questions

These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.
Recent research and studies
clinicaltrials.govStudy
Thalamic Low Intensity Focused Ultrasound in Brain Injury
Martin M Monti 2016. "Thalamic Low Intensity Focused Ultrasound in Brain Injury". ClinicalTrials.gov. https://clinicaltrials.gov/ct2/show/NCT02522429.
~3 spots leftby Apr 2025
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