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Behavioral Intervention

Spatiomotor Rehabilitation for Blindness & Visual Impairment

N/A

Recruiting

Led By Lora T Likova

Research Sponsored by Smith-Kettlewell Eye Research Institute

Eligibility Criteria Checklist

Specific guidelines that determine who can or cannot participate in a clinical trial

Must have

Be older than 18 years old

Timeline

Screening 3 weeks

Treatment Varies

Follow Up 3-6 months

Awards & highlights

Study Summary

This trial will test a new rehabilitation method to help improve the navigational abilities of people who are blind or visually impaired, and study the brain changes that result from the training.

Who is the study for?

This trial is for individuals with severe vision impairment or blindness, comfortable with MRI procedures, and within the average height and weight range for their gender. They must be able to control their limbs and hear/understand instructions. Those with metal implants or who can't fit in an MRI machine cannot participate.Check my eligibility

What is being tested?

The study tests Cognitive-Kinesthetic Navigational Training designed to improve navigation skills in blind or visually impaired people by enhancing spatial cognition. It also examines changes in brain structure through advanced imaging techniques.See study design

What are the potential side effects?

Since this intervention involves training rather than medication, traditional side effects are not expected. However, participants may experience fatigue or mental strain from the cognitive exercises involved.

Timeline

Screening ~ 3 weeks3 visits

Treatment ~ Varies

Follow Up ~ 3-6 months

Screening ~ 3 weeks

Treatment ~ Varies

Follow Up ~3-6 months

This trial's timeline: 3 weeks for screening, Varies for treatment, and 3-6 months for reporting.

Treatment Details

Study Objectives

Outcome measures can provide a clearer picture of what you can expect from a treatment.

Primary outcome measures

Change in Granger causal connectivity (GCC) density in the cortical navigation network

Change in blind map drawing errors from Pre to Post1 timepoints

Change in blind map drawing speed from pre-training (Pre) to immediate post-training (Post1) timepoints

+11 more

Secondary outcome measures

Change in Diffusion Tensor Imaging (DTI) in the cortical navigation network

Change in mobility self-assessment

Maintenance of change in Diffusion Tensor Imaging (DTI) in the cortical navigation network

+2 more

Other outcome measures

Age

Age of onset of current level of vision

Current level of vision

+3 more

Trial Design

1Treatment groups

Experimental Treatment

Group I: Blindness historyExperimental Treatment1 Intervention

Since this is a regression analysis, all participants are assigned to the same Arm with blindness history and the demographics as covariates.

Do I qualify?Apply below to find out

Find a Location

Who is running the clinical trial?

Smith-Kettlewell Eye Research InstituteLead Sponsor

4 Previous Clinical Trials

298 Total Patients Enrolled

Lora T LikovaPrincipal InvestigatorSenior Scientist

Media Library

Cognitive-Kinesthetic Navigational Training (Behavioral Intervention) Clinical Trial Eligibility Overview. Trial Name: NCT05377853 — N/A

Blindness Research Study Groups: Blindness history

Blindness Clinical Trial 2023: Cognitive-Kinesthetic Navigational Training Highlights & Side Effects. Trial Name: NCT05377853 — N/A

Cognitive-Kinesthetic Navigational Training (Behavioral Intervention) 2023 Treatment Timeline for Medical Study. Trial Name: NCT05377853 — N/A

Frequently Asked Questions

These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.

Are elderly participants being enrolled in this experiment?

"This medical experiment is open to individuals aged 18 and above, up until the age of 80."

Answered by AI

How many participants are currently enrolled in this research project?

"Affirmative. The details of this medical trial, first posted on February 15th 2022, are publicly accessible via clinicaltrials.gov and it is currently recruiting participants - 75 individuals from 1 treatment site."

Answered by AI

Do I meet the criteria to take part in this scientific research?

"The goal of this clinical trial is to recruit 75 people with amaurosis aged 18-80. Essential eligibility requirements include visual acuity between 20/500 and NLP, physical size within 1 standard deviation of the average for their gender, tolerance towards MRI scans, and more."

Answered by AI

Are there any opportunities for patients to participate in this trial at present?

"All the data on clinicaltrials.gov points to this trial being actively open for recruitment, with a launch date of February 15th 2022 and its latest amendment made May 11th 2022."

Answered by AI

What goals are this trial hoping to accomplish?

"The primary outcome assessed over a 3-6 month time span will be the maintenance of change in GCC density in the cortical navigation network. Secondary outcomes include transfer of training to untrained spatio-cognitive abilities, measured by score on the Cognitive Test for the Blind (CTB) of McCarron Dial Comprehensive Vocational Evaluation System; change in mobility self-assessment as determined by Kuyk Mobility Function Questionnaire for blindness and profound visual impairment; and maintenance of transfer of training to untrained spatio cognitive abilities, also measured by CTB scores."

Answered by AI

Recent research and studies

Frontiers in PsychologyJournal

A Cross-modal Perspective on the Relationships Between Imagery and Working Memory

Likova, Lora T.. 2013. “A Cross-modal Perspective on the Relationships Between Imagery and Working Memory”. Frontiers in Psychology. Frontiers Media SA. doi:10.3389/fpsyg.2012.00561.

Frontiers in Systems NeuroscienceJournal

Mental Visualization in the Cerebellum: Rapid Non-motor Learning at Sub-lobular and Causal Network Levels

Likova, Lora T., Kristyo N. Mineff, and Spero C. Nicholas. 2021. “Mental Visualization in the Cerebellum: Rapid Non-motor Learning at Sub-lobular and Causal Network Levels”. Frontiers in Systems Neuroscience. Frontiers Media SA. doi:10.3389/fnsys.2021.655514.

Frontiers in Human NeuroscienceJournal

Drawing Enhances Cross-modal Memory Plasticity in the Human Brain: A Case Study in a Totally Blind Adult

Likova, Lora T.. 2012. “Drawing Enhances Cross-modal Memory Plasticity in the Human Brain: A Case Study in a Totally Blind Adult”. Frontiers in Human Neuroscience. Frontiers Media SA. doi:10.3389/fnhum.2012.00044.

Electronic ImagingJournal