Cognitive-Kinesthetic Navigational Training for Amaurosis

Phase-Based Progress Estimates
1
Effectiveness
1
Safety
Smith-Kettlewell Eye Research Institute, San Francisco, CA
Amaurosis+4 More
Cognitive-Kinesthetic Navigational Training - Behavioral
Eligibility
18+
All Sexes
What conditions do you have?
Select

Study Summary

One of the most challenging tasks for blind and visually impaired individuals is navigation through a complex environment. The goal of the present multidisciplinary study is to increase spatial-cognition abilities in people who are blind or visually impaired through training with the previously-developed Cognitive-Kinesthetic Rehabilitation Training to improve navigation, and to investigate the resultant neuroplastic brain reorganization through multimodal brain imaging. In accordance with National Eye Institute (NEI) strategic goals, this multidisciplinary project will promote the development of well-informed new approaches to navigational rehabilitation, memory enhancement and cross-modal brain plasticity to benefit 'cutting edge' fields of mobile assistive technologies, vision restoration and memory facilitation for the aging brain.

Eligible Conditions

  • Amaurosis
  • Vision, Low
  • Blindness, Acquired
  • Blindness, Complete

Treatment Effectiveness

Study Objectives

14 Primary · 5 Secondary · Reporting Duration: 3-6 months

3-6 months
Change in mobility self-assessment
Maintenance of change in Diffusion Tensor Imaging (DTI) in the cortical navigation network
Maintenance of change in GCC density in the cortical navigation network
Maintenance of change in blind map drawing errors from Post1 to Post2 timepoints
Maintenance of change in blind map drawing speed from Post1 to extended post-training (Post2) timepoints
Maintenance of change in fMRI activation in the cortical navigation network
Maintenance of change in fMRI activation in the spatial working memory network
Maintenance of change in number of total navigation time during blind navigation of the shortest path at macro-scale from Post1 to Post2 timepoints
Maintenance of change in total number of contact errors during blind macro-scale navigation from Post1 to Post2 timepoints
Maintenance of transfer of training to untrained spatio-cognitive abilities
6-10 days
Change in Diffusion Tensor Imaging (DTI) in the cortical navigation network
Change in Granger causal connectivity (GCC) density in the cortical navigation network
Change in blind map drawing errors from Pre to Post1 timepoints
Change in blind map drawing speed from pre-training (Pre) to immediate post-training (Post1) timepoints
Change in functional MRI (fMRI) activation in the cortical navigation network
Change in functional MRI (fMRI) activation in the spatial working memory network
Change in total navigation time during blind macro-scale navigation of the shortest path from Pre to Post1 timepoints
Change in total number of contact errors during blind macro-scale navigation from Pre to Post1 timepoints
Transfer of training to untrained spatio-cognitive abilities
Pre-training timepoint
Age
Age of onset of current level of vision
Current level of vision
Duration of Orientation and Mobility (O&M) training
Duration of full vision
Pre-training timepoint.
Gender

Trial Safety

Trial Design

1 Treatment Group

Blindness history
1 of 1
Experimental Treatment

75 Total Participants · 1 Treatment Group

Primary Treatment: Cognitive-Kinesthetic Navigational Training · No Placebo Group · N/A

Blindness history
Behavioral
Experimental Group · 1 Intervention: Cognitive-Kinesthetic Navigational Training · Intervention Types: Behavioral

Trial Logistics

Trial Timeline

Approximate Timeline
Screening: ~3 weeks
Treatment: Varies
Reporting: 3-6 months
Closest Location: Smith-Kettlewell Eye Research Institute · San Francisco, CA
Photo of San Francisco 1Photo of San Francisco 2Photo of San Francisco 3
N/AFirst Recorded Clinical Trial
0 TrialsResearching Amaurosis
0 CompletedClinical Trials

Who is running the clinical trial?

Smith-Kettlewell Eye Research InstituteLead Sponsor
4 Previous Clinical Trials
298 Total Patients Enrolled
Lora T LikovaPrincipal InvestigatorSenior Scientist

Eligibility Criteria

Age 18+ · All Participants · 5 Total Inclusion Criteria

Mark “yes” if the following statements are true for you:
Vision from 20/500 to NLP (No Light Perception) is impaired.
You have a height within the average range for your gender.
You are within the average weight range for your gender.
You are comfortable with MRI procedures.

About The Reviewer

Michael Gill preview

Michael Gill - B. Sc.

First Published: October 9th, 2021

Last Reviewed: August 12th, 2022

Michael Gill holds a Bachelors of Science in Integrated Science and Mathematics from McMaster University. During his degree he devoted considerable time modeling the pharmacodynamics of promising drug candidates. Since then, he has leveraged this knowledge of the investigational new drug ecosystem to help his father navigate clinical trials for multiple myeloma, an experience which prompted him to co-found Power Life Sciences: a company that helps patients access randomized controlled trials.

References