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Procedure

Double Sequential Defibrillation for Cardiac Arrest (DOSEVF Trial)

N/A
Waitlist Available
Led By Sheldon Cheskes, MD
Research Sponsored by Sunnybrook Health Sciences Centre
Eligibility Criteria Checklist
Specific guidelines that determine who can or cannot participate in a clinical trial
Must have
Be older than 18 years old
Timeline
Screening 3 weeks
Treatment Varies
Follow Up throughout study completion of three years
Awards & highlights

DOSEVF Trial Summary

This trial will compare three methods of resuscitation for patients in refractory ventricular fibrillation (VF) during out-of-hospital cardiac arrest: (1) standard defibrillation; (2) double sequential external defibrillation (DSED); or (3) vector change defibrillation.

Eligible Conditions
  • Cardiac Arrest
  • Ventricular Fibrillation

DOSEVF Trial Timeline

Screening ~ 3 weeks
Treatment ~ Varies
Follow Up ~through study completion of three years
This trial's timeline: 3 weeks for screening, Varies for treatment, and through study completion of three years for reporting.

Treatment Details

Study Objectives

Outcome measures can provide a clearer picture of what you can expect from a treatment.
Primary outcome measures
Survival to Hospital Discharge
Secondary outcome measures
Neurologic outcome
Electric Countershock
Return of Spontaneous Circulation
+2 more

DOSEVF Trial Design

3Treatment groups
Active Control
Group I: Standard ArmActive Control1 Intervention
All defibrillation attempts will occur using the standard defibrillation method, i.e. defibrillation pads will be placed in the anterior-anterior configuration. The patient may also be administered antiarrythmic agents and epinephrine, as per current provincial standard.
Group II: Double Sequential DefibrillationActive Control1 Intervention
The first three shocks will occur with defibrillation pads placed in the anterior-anterior position. For all further shocks, a second set of defibrillation pads (via a second on scene EMS or fire defibrillator) will be applied in the anterior-posterior position, and defibrillation will be carried out by sequential defibrillation shocks provided by the two defibrillators (i.e. with a short delay between the two defibrillators). The patient may also be administered antiarrythmic agents and epinephrine, as per current provincial standard.
Group III: Vector Change DefibrillationActive Control1 Intervention
The first three shocks will occur with defibrillation pads placed in the anterior-anterior position. All further shocks will occur with the pads placed in the anterior-posterior position. The patient may also be administered antiarrythmic agents and epinephrine, as per current provincial standard.

Find a Location

Who is running the clinical trial?

Toronto Paramedic ServicesUNKNOWN
1 Previous Clinical Trials
173 Total Patients Enrolled
Halton Region Paramedic ServicesOTHER
2 Previous Clinical Trials
1,795 Total Patients Enrolled
Ottawa Paramedic ServiceUNKNOWN
1 Previous Clinical Trials
192 Total Patients Enrolled

Frequently Asked Questions

These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.
Recent research and studies
clinicaltrials.govStudy
DOuble SEquential External Defibrillation for Refractory VF
2019. "DOuble SEquential External Defibrillation for Refractory VF". ClinicalTrials.gov. https://clinicaltrials.gov/ct2/show/NCT04080986.
~73 spots leftby Apr 2025
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