← Back to Search

Norepinephrine for Vasodilation

Q: Are individuals aged 70 or younger being included in this clinical study?

Patients within the age range of 18 to 45 years old are eligible for this trial.

Q: Is recruitment currently active for this research trial?

Verified by clinicaltrials.gov, this particular research project is no longer recruiting participants having initially been posted on July 28th 2022 and last updated October 27th of the same year. At present, 18 additional studies are actively seeking enrollees to continue their investigations.

Q: Could I potentially participate in this trial?

Generally, the ideal participants for this clinical trial would have vasoconstriction and fall between 18 to 45 years old. As of now, 20 candidates are needed for enrollment.

N/A

Waitlist Available

Led By Sean van Diepen, MD, MSc

Research Sponsored by University of Alberta

Eligibility Criteria Checklist

Specific guidelines that determine who can or cannot participate in a clinical trial

Must have

Be between 18 and 65 years old

Timeline

Screening 3 weeks

Treatment Varies

Follow Up 1 hour 30 minutes

Awards & highlights

Study Summary

This trial looks at how different sexes react to low oxygen levels, and how quickly they adapt to it.

Eligible Conditions

Vasodilation
Vasoconstriction

Timeline

Screening ~ 3 weeks3 visits

Treatment ~ Varies

Follow Up ~ 1 hour 30 minutes

Screening ~ 3 weeks

Treatment ~ Varies

Follow Up ~1 hour 30 minutes

This trial's timeline: 3 weeks for screening, Varies for treatment, and 1 hour 30 minutes for reporting.

Treatment Details

Study Objectives

Outcome measures can provide a clearer picture of what you can expect from a treatment.

Primary outcome measures

Change in arterial blood flow

Systemic arterial pressure

Change in vascular conductance

+3 more

Side effects data

From 2015 Phase 4 trial • 85 Patients • NCT02354833

63%

Nausea

100%

80%

60%

40%

20%

Study treatment Arm

Phenylephrine

Norepinephrine

Trial Design

2Treatment groups

Experimental Treatment

Group I: Low AltitudeExperimental Treatment8 Interventions

Participants will be assessed at an altitude of <1050m.

Group II: High AltitudeExperimental Treatment8 Interventions

Participants will be assessed on a high-altitude expedition at an elevation of 3,800m.

Treatment

First Studied

Drug Approval Stage

How many patients have taken this drug

Propranolol Hydrochloride

2021

Completed Phase 3

~130

Sodium Nitroprusside

2018

Completed Phase 1

~220

Phenylephrine Hydrochloride

2019

N/A

~50

Norepinephrine

2014

Completed Phase 4

~1780

Phentolamine Mesylate

2022

N/A

~20

Do I qualify?Apply below to find out

Find a Location

Who is running the clinical trial?

University of AlbertaLead Sponsor

886 Previous Clinical Trials

384,761 Total Patients Enrolled

3 Trials studying Vasodilation

63 Patients Enrolled for Vasodilation

Sean van Diepen, MD, MScPrincipal InvestigatorUniversity of Alberta

3 Previous Clinical Trials

63 Total Patients Enrolled

3 Trials studying Vasodilation

63 Patients Enrolled for Vasodilation

Craig D Steinback, PhDPrincipal InvestigatorUniversity of Alberta

Frequently Asked Questions

These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.

Are individuals aged 70 or younger being included in this clinical study?

"Patients within the age range of 18 to 45 years old are eligible for this trial."

Answered by AI

Is recruitment currently active for this research trial?

"Verified by clinicaltrials.gov, this particular research project is no longer recruiting participants having initially been posted on July 28th 2022 and last updated October 27th of the same year. At present, 18 additional studies are actively seeking enrollees to continue their investigations."

Answered by AI

Could I potentially participate in this trial?

"Generally, the ideal participants for this clinical trial would have vasoconstriction and fall between 18 to 45 years old. As of now, 20 candidates are needed for enrollment."

Answered by AI

Recent research and studies

HypertensionJournal

Sex Differences in Sympathetic Neural-hemodynamic Balance

Hart, Emma C., Nisha Charkoudian, B. Gunnar Wallin, Timothy B. Curry, John H. Eisenach, and Michael J. Joyner. 2009. “Sex Differences in Sympathetic Neural-hemodynamic Balance”. Hypertension. Ovid Technologies (Wolters Kluwer Health). doi:10.1161/hypertensionaha.108.126391.

Journal of Applied PhysiologyJournal

Catecholamine Response During 12 Days of High-altitude Exposure (4,300 M) in Women

Mazzeo, Robert S., Avon Child, Gail E. Butterfield, Jacinda T. Mawson, Stacy Zamudio, and Lorna G. Moore. 1998. “Catecholamine Response During 12 Days of High-altitude Exposure (4,300 M) in Women”. Journal of Applied Physiology. American Physiological Society. doi:10.1152/jappl.1998.84.4.1151.

American Journal of Physiology-Heart and Circulatory PhysiologyJournal

Menstrual Cycle and Sex Effects on Sympathetic Responses to Acute Chemoreflex Stress

Usselman, Charlotte W., Tamara I. Gimon, Chantelle A. Nielson, Torri A. Luchyshyn, Nicole S. Coverdale, Stan H. M. Van Uum, and J. Kevin Shoemaker. 2015. “Menstrual Cycle and Sex Effects on Sympathetic Responses to Acute Chemoreflex Stress”. American Journal of Physiology-heart and Circulatory Physiology. American Physiological Society. doi:10.1152/ajpheart.00345.2014.

Journal of Applied PhysiologyJournal