Vaccine Information Videos for Vaccinations

(Conectados Trial)

Overseen By Lucia Abascal Moguel, MD, PhD

Age: 18+

Sex: Any

Trial Phase: Academic

Sponsor: University of California, San Francisco

Disqualifiers: Under 18, Not in California, others

No Placebo Group All trial participants will receive the active study treatment (no placebo)

Compensation: Varies

Number of Visits: Unknown

What You Need to Know Before You Apply

What is the purpose of this trial?

This trial explores how sharing a short video about flu and COVID-19 vaccines can influence trust and decision-making regarding vaccination. Indigenous community members in California contributed to the video's creation. It will be shared in three ways: through social media ads, by trusted community organizations, or through personal connections. Participants will watch the video, answer a trust question, and may complete a survey about their vaccine views. The goal is to observe how trust in vaccine information changes based on the source, aiming to enhance health messaging in Indigenous and underserved communities. Individuals living in California with internet access who can view online videos and complete surveys are well-suited for the trial. As an unphased trial, this study allows participants to contribute to improving health communication strategies in their communities.

Do I have to stop taking my current medications to join the trial?

The trial information does not specify whether you need to stop taking your current medications. It seems unlikely, as the study focuses on watching a video and answering questions about it.

What prior data suggests that this video is safe for sharing?

Research has shown that both flu and COVID-19 vaccines are generally safe for people. COVID-19 vaccines help the body build protection without causing illness. The Centers for Disease Control and Prevention (CDC) provides Vaccine Information Statements that explain the benefits and risks of vaccines, helping individuals know what to expect.

The flu vaccine is commonly given to children, seniors, pregnant individuals, and those with certain health conditions, indicating its high safety.

In this study, participants will watch an informational video. No medication is involved, so there are no safety risks from viewing it. Participants are simply asked to watch the video and share their thoughts. ^{1 2 3}

Why are researchers excited about this trial?

Researchers are excited about this trial because it explores innovative ways to boost vaccine confidence using digital media. Unlike traditional methods like brochures or doctor consultations, this trial uses short, engaging videos distributed through social media and community channels. These videos are tailored to reach people where they spend their time online, making the information more accessible and shareable. By leveraging personal networks and trusted community organizations, the trial aims to enhance trust in vaccine information and encourage wider dissemination of reliable health messages.

What evidence suggests that this video is effective for improving trust in vaccine information?

Research shows that COVID-19 and flu vaccines effectively reduce serious outcomes like hospitalization and death. Studies have found that flu vaccines can be about 67% effective in children, greatly lowering the chance of getting the flu. Regular checks confirm that flu vaccines help keep people healthier. In this trial, participants will view educational videos about these vaccines through various methods, such as social media, community-based organizations, or personal networks. The videos aim to share important information to increase understanding and trust. By presenting reliable facts, the videos help people make informed decisions about vaccination. ^{4 5 6 7 8}

Who Is on the Research Team?

Nadia Diamond-Smith, PhD, MS

Principal Investigator

University of California, San Francisco

Are You a Good Fit for This Trial?

This trial is for individuals interested in vaccine information, particularly those from Indigenous communities in California. It's open to people who are willing to watch a video about flu and COVID-19 vaccines and answer questions regarding their trust in the video and their views on vaccination.

Inclusion Criteria

Able to access and view an online video

For Arm 2 only: must have participated in the prior Aim 1 survey and consented to recontact

Currently resides in California

Exclusion Criteria

Does not reside in California

Unable to access the internet to view the intervention video or complete the survey

I am under 18 years old.

Timeline for a Trial Participant

Screening

Participants are screened for eligibility to participate in the trial

1-2 weeks

Intervention

Participants view a culturally tailored video about flu and COVID-19 vaccines through different dissemination methods

Immediately

Online interaction

Survey and Data Collection

Participants respond to a poll and may complete an optional survey assessing trust and vaccine attitudes

Immediately after video exposure

Online interaction

Follow-up

Participants' trust levels and vaccine intentions are analyzed based on dissemination method

1-2 weeks

What Are the Treatments Tested in This Trial?

Interventions

• Vaccine Information Video

Trial Overview The study tests how different methods of sharing a community-informed vaccine information video affect viewers' trust. The dissemination channels include social media ads, trusted community organizations, or personal contacts.

How Is the Trial Designed?

Group I: Participant seed Experimental Treatment 1 Intervention

Participants in this arm are individuals who previously completed a related survey and consented to be recontacted. These "seed" participants receive a personalized video link and instructions to share it with at least 10 people in their personal networks. They will first watch the same 2-3 minute vaccine education video, answer a 1-question poll ("How much do you trust this video?"), and complete an anonymous online survey assessing vaccine attitudes, trust in the message and source, and willingness to share. Recipients of their shared video link may also complete the poll and survey. Sharing patterns are tracked via unique link analytics.

Group II: Community based organizations Experimental Treatment 1 Intervention

Participants in this arm will view a short educational video about flu and COVID-19 vaccines distributed by trusted community-based organizations (CBOs) using their usual communication methods, such as WhatsApp, email, newsletters, or social media. After watching the video, participants will be asked to answer a 1-question poll ("How much do you trust this video?") and will be invited to complete an optional, anonymous online survey assessing vaccine attitudes, trust in the source of the information, and willingness to share the video. CBOs will use unique tracking links to monitor video engagement.

Group III: Social media Active Control 1 Intervention

Participants in this arm will view a short (2-3 minute) educational video about flu and COVID-19 vaccines through paid advertisements on Facebook and Instagram. After viewing the video, they will be asked to respond to a single poll question: "How much do you trust this video?" Participants will then be invited to complete an optional, anonymous online survey assessing vaccine confidence, trust in the information source, and willingness to share the video. All procedures are self-directed and occur online.

Who Is Running the Clinical Trial?

University of California, San Francisco

Lead Sponsor

Trials

2,636

Recruited

19,080,000+

Citations

1. nejm.org nejm.org/doi/full/10.1056/NEJMsa2514268

Updated Evidence for Covid-19, RSV, and Influenza ... Children. Six case–control studies involving a pooled pediatric population showed an influenza vaccine effectiveness of 67% (95% CI, 58 to 75) ...

2. cdc.gov cdc.gov/flu-vaccines-work/php/effectiveness-studies/index.html

CDC Seasonal Flu Vaccine Effectiveness Studies CDC conducts studies each flu season to help determine how well flu vaccines are working. These vaccine effectiveness (VE) studies help regularly assess the ...

3. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov/articles/PMC11724835/

The Impact of Vaccination on COVID-19, Influenza, and ... Vaccines for COVID-19 (caused by SARS-CoV-2) and influenza are effective against the most severe outcomes, such as hospitalization and death.

4. youtube.com youtube.com/watch?v=ZyX2mLPlKSw

Flu vac causing flu Bottom line of this video, Flu jab, calculated vaccine effectiveness of −26.9% N = 43,857 'This study found a significantly higher risk of ...

5. nature.com nature.com/articles/s41541-025-01145-6

Comparing Moderna's mRNA-1083 and Pfizer's dual-target ... This review examines Moderna's mRNA-1083 and Pfizer/BioNTech's mRNA-1020/1030 dual-target vaccines for COVID-19 and influenza.

6. cdc.gov cdc.gov/covid/vaccines/how-they-work.html

COVID-19 Vaccine Basics COVID-19 vaccines help our bodies develop immunity to the virus that causes COVID-19 without us having to get the illness.

7. immunize.org immunize.org/vaccines/vis/about-vis/

Vaccine Information Statements (VISs) Overview Vaccine Information Statements are information sheets produced by CDC that explain both the benefits and risks of a vaccine to vaccine recipients.

8. youtube.com youtube.com/watch?v=EZe8D9IaTAY

Get the Flu Vaccine - Protect Yourself, Protect Others (English) The flu vaccine is free to all children aged 2 – 17, all adults 65 or older, people who are pregnant and people who have medical conditions ...