HPV Vaccine Videos for Vaccinations

Overseen By Michelle Goryn

Age: Any Age

Sex: Any

Trial Phase: Academic

Sponsor: Johns Hopkins Bloomberg School of Public Health

Disqualifiers: Children vaccinated, Incomplete survey, Unable to view videos

No Placebo Group All trial participants will receive the active study treatment (no placebo)

Compensation: Varies

Number of Visits: 1

1100 Participants Needed

What You Need to Know Before You Apply

What is the purpose of this trial?

This trial aims to determine which type of video—informational, personal story, or a mix of both—best encourages HPV vaccinations. The focus is on the HPV vaccine, which prevents certain cancers caused by the human papillomavirus. Parents of 11-17-year-olds who haven't yet received the HPV vaccine are ideal candidates for this trial. Participants will watch various videos about the vaccine to identify the most convincing approach. As an unphased trial, this study provides a unique opportunity to contribute to public health by identifying effective communication strategies for increasing HPV vaccination rates.

What prior data suggests that these HPV vaccine videos are safe for viewers?

Research has shown that the HPV vaccine is safe and generally well-tolerated. Since its approval in the United States in 2006, studies have consistently confirmed its safety. Most recipients do not experience serious side effects. Common reactions may include mild soreness at the injection site or a slight fever, typical for many vaccines.

The video treatments in this study are not physically invasive. Designed to inform and educate about the HPV vaccine, these videos pose no safety concerns. They aim to help individuals make informed decisions about vaccination. ^{1 2 3 4 5}

Why are researchers excited about this trial?

Researchers are excited about this trial because it explores new ways to boost HPV vaccination rates using video content. Unlike traditional methods that rely on brochures or verbal information, this trial tests video formats like animations and personal narratives, which might be more engaging and relatable. By tailoring personal stories to the viewer, the narrative videos could make the information more impactful and increase vaccine uptake. The combination of animation and narrative might also help clarify complex information, making it easier for people to understand why getting vaccinated is important. Researchers hope to find out which video approach, if any, is most effective at encouraging people to get vaccinated against HPV.

What evidence suggests that these HPV vaccine videos are effective in increasing vaccination rates?

Research has shown that videos can improve understanding and positivity about the HPV vaccine. In this trial, participants will view various video formats. Some studies have found that videos, especially when combined with text message reminders, increase vaccination rates. Videos featuring personal experiences with HPV have also succeeded. One study found that these personal stories nearly doubled vaccination rates within two months. This trial will test whether combining informational videos with personal stories enhances effectiveness, as different people are drawn to different types of content. ^{6 7 8 9 10}

Who Is on the Research Team?

Daniel Salmon, PhD

Principal Investigator

Johns Hopkins University

Are You a Good Fit for This Trial?

This trial is for parents of children aged 11-17 who have not yet received the HPV vaccine. It aims to find out if different types of videos can encourage vaccination.

Inclusion Criteria

My child, aged 11-17, has not received the HPV vaccine.

Timeline for a Trial Participant

Screening

Participants are screened for eligibility to participate in the trial

2-4 weeks

Intervention

Participants are exposed to different video interventions to assess their impact on HPV vaccination uptake

1 day

1 visit (in-person or virtual)

Follow-up

Participants are monitored for HPV vaccination uptake

9 months

What Are the Treatments Tested in This Trial?

Interventions

• HPV Vaccine Information Video
• Viewer-tailored Personal Human Papillomavirus (HPV) Narrative Video

Trial Overview The study is testing three approaches: informational animation videos about HPV, personal narrative videos sharing individual stories, and a combination of both, to see which method increases HPV vaccine uptake the most.

How Is the Trial Designed?

Group I: Narrative Then Animation Experimental Treatment 2 Interventions

personal narrative video followed immediately by the informational animation video

Group II: Narrative Only Experimental Treatment 1 Intervention

personal narrative video only

Group III: Animation Then Narrative Experimental Treatment 2 Interventions

informational animation video followed immediately by the personal narrative video

Group IV: Animation Only Experimental Treatment 1 Intervention

informational animation video only

Group V: Control Active Control 1 Intervention

No videos

Who Is Running the Clinical Trial?

Johns Hopkins Bloomberg School of Public Health

Lead Sponsor

Trials

441

Recruited

2,157,000+

Merck Sharp & Dohme LLC

Industry Sponsor

Trials

4,096

Recruited

5,232,000+

Chirfi Guindo

Merck Sharp & Dohme LLC

Chief Marketing Officer since 2022

Degree in Engineering from Ecole Centrale de Paris, MBA from New York University Stern School of Business

Robert M. Davis

Merck Sharp & Dohme LLC

Chief Executive Officer since 2021

JD from Northwestern University Pritzker School of Law, MBA from Northwestern University Kellogg Graduate School of Management, Bachelor's in Finance from Miami University

Citations

1. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov/articles/PMC12501893/

momentary intervention effects of an educational video - PMC Video- and Short Message Service (SMS)-based prompts have been demonstrated to improve vaccine knowledge, attitudes, and uptake, thus supporting ...

2. nature.com nature.com/articles/s41599-024-03644-8

Promoting HPV vaccination: effectiveness of mobile short ... This study seeks to investigate if and how HPV vaccine information delivered via mobile short videos (MSVs) can persuade individuals to decide ...

3. sciencedirect.com sciencedirect.com/science/article/pii/S2772628222000966

Digital HPV education to increase vaccine uptake among ... Optimizing kiosk design and information delivery can improve HPV vaccine uptake. ... vaccination reminder text messages and additional HPV vaccine information.

4. jmir.org jmir.org/2025/1/e67778

Web-Based Video Intervention and Associated Factors for ... Objective: This study aims to evaluate the effect of video-based informational intervention and explore factors associated with the uptake of ...

5. clinicaltrials.gov clinicaltrials.gov/study/NCT06587243

Study Details | NCT06587243 | "Facts Tell… and With ... Personal narrative videos will consist of someone describing the person's own personal experience with HPV. The investigators have a collection of videos of ...

6. youtube.com youtube.com/watch?v=4snd3NzXhrA&vl=en-US

HPV Vaccine Explained: Safety, Myths, and How It Prevents ... Cancer prevention in a shot? Yep. Here's the truth about the HPV vaccine—what it does, who it's for, and why the myths don't hold up.

7. youtube.com youtube.com/watch?v=40Sv7hFOxgs

Is the HPV vaccine safe? | Dr. Offit Answers YOUR Question ... Ever since the HPV vaccine was licensed for use in the United States in 2006, people have wondered whether it is safe. In this short video, ...

8. facebook.com facebook.com/TheNewEnglandJournalofMedicine/videos/in-this-double-take-video-dr-julie-barzilay-discusses-the-connection-between-cer/1909528223231012/

In this Double Take video, Dr. Julie Barzilay discusses the ... In this Double Take video, Dr. Julie Barzilay discusses the connection between certain strains of human papillomavirus (HPV) and cancer, as well ...

9. youtube.com youtube.com/watch?v=NukU5pdLvzw

Human Papillomavirus and Cancer | NEJM There are highly effective vaccines that can prevent HPV infection and decrease the burden of disease due to HPV.

10. instagram.com instagram.com/reel/DPO1rObghX2/?hl=en

HPV Vaccine: Understanding Efficacy, Safety, and Protection The HPV vaccine can prevent HPV infection and safeguard against cervical and other HPV-associated cancers. Check out this video for more ...