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Non-invasive Brain Stimulation

Repetitive Transcranial Magnetic Stimulation for Overactive Bladder

Phase < 1
Waitlist Available
Research Sponsored by University of Southern California
Eligibility Criteria Checklist
Specific guidelines that determine who can or cannot participate in a clinical trial
Must have
Be older than 18 years old
Timeline
Screening 3 weeks
Treatment Varies
Follow Up feasibility will be assessed after completion of the study, up to 6 months.
Awards & highlights

Study Summary

This study is evaluating whether repetitive transcranial magnetic stimulation (rTMS) can be used to treat overactive bladder (OAB) in women.

Eligible Conditions
  • Overactive Bladder
  • Urge Incontinence

Timeline

Screening ~ 3 weeks
Treatment ~ Varies
Follow Up ~feasibility will be assessed after completion of the study, up to 6 months.
This trial's timeline: 3 weeks for screening, Varies for treatment, and feasibility will be assessed after completion of the study, up to 6 months. for reporting.

Treatment Details

Study Objectives

Outcome measures can provide a clearer picture of what you can expect from a treatment.
Primary outcome measures
Effects of rTMS on pelvic floor muscle activity after high-frequency rTMS
Effects of rTMS on pelvic floor muscle activity after low-frequency rTMS
Effects of rTMS on pelvic-SMA activity after high-frequency rTMS
+1 more
Secondary outcome measures
Assess objective OAB and UUI symptom changes following rTMS
Assess subjective OAB and UUI symptom changes following rTMS
Other outcome measures
Feasibility of repetitive transcranial magnetic stimulation (rTMS) use in women with overactive bladder (OAB) and urgency urinary incontinence (UUI)

Trial Design

2Treatment groups
Experimental Treatment
Group I: Low Frequency rTMS ProtocolExperimental Treatment1 Intervention
Low frequency 1 Hz at 80% motor threshold intensity with figure-of-eight coil for a total of 2,000 pulses. Pulses will be delivered continuously.
Group II: High Frequency rTMS ProtocolExperimental Treatment1 Intervention
High frequency with 10 Hz at 80% motor threshold intensity with figure-of-eight coil for a total of 2,000 pulses. Pulses will be delivered in 10-second trains with a 50-second pause between the trains.
Treatment
First Studied
Drug Approval Stage
How many patients have taken this drug
Repetitive Transcranial Magnetic Stimulation
2013
Completed Phase 3
~1170

Find a Location

Who is running the clinical trial?

University of Southern CaliforniaLead Sponsor
905 Previous Clinical Trials
1,596,308 Total Patients Enrolled
Larissa Rodriguez, MDStudy DirectorUniversity of Southern California

Frequently Asked Questions

These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.

Who else is applying?

What state do they live in?
California
How old are they?
18 - 65
What site did they apply to?
University of Southern California
What portion of applicants met pre-screening criteria?
Met criteria
Recent research and studies
Clinical NeurophysiologyJournal
Seizures from Transcranial Magnetic Stimulation 2012–2016: Results of a Survey of Active Laboratories and Clinics
Lerner, Adam J., Eric M. Wassermann, and Diana I. Tamir. 2019. “Seizures from Transcranial Magnetic Stimulation 2012–2016: Results of a Survey of Active Laboratories and Clinics”. Clinical Neurophysiology. Elsevier BV. doi:10.1016/j.clinph.2019.03.016.
Clinical NeurophysiologyJournal
Evidence-based Guidelines on the Therapeutic Use of Repetitive Transcranial Magnetic Stimulation (rtms)
Lefaucheur, Jean-Pascal, Nathalie André-Obadia, Andrea Antal, Samar S. Ayache, Chris Baeken, David H. Benninger, Roberto M. Cantello, et al.. 2014. “Evidence-based Guidelines on the Therapeutic Use of Repetitive Transcranial Magnetic Stimulation (rtms)”. Clinical Neurophysiology. Elsevier BV. doi:10.1016/j.clinph.2014.05.021.
Current Bladder Dysfunction ReportsJournal
The Burden of Overactive Bladder on US Public Health
Reynolds, W. Stuart, Jay Fowke, and Roger Dmochowski. 2016. “The Burden of Overactive Bladder on US Public Health”. Current Bladder Dysfunction Reports. Springer Science and Business Media LLC. doi:10.1007/s11884-016-0344-9.
Journal of UrologyJournal
Diagnosis and Treatment of Overactive Bladder (non-neurogenic) in Adults: AUA/SUFU Guideline Amendment 2019
Lightner, Deborah J., Alexander Gomelsky, Lesley Souter, and Sandip P. Vasavada. 2019. “Diagnosis and Treatment of Overactive Bladder (non-neurogenic) in Adults: AUA/SUFU Guideline Amendment 2019”. Journal of Urology. Ovid Technologies (Wolters Kluwer Health). doi:10.1097/ju.0000000000000309.
All > Overactive Bladder > Transcranial Magnetic Stimulation
~3 spots leftby Apr 2025
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