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Hormone Therapy

Growth Hormone for Turner Syndrome

N/A
Waitlist Available
Led By Rebecca Knickmeyer
Research Sponsored by Rebecca Knickmeyer Santelli, PhD
Eligibility Criteria Checklist
Specific guidelines that determine who can or cannot participate in a clinical trial
Must have
Be younger than 18 years old
Timeline
Screening 3 weeks
Treatment Varies
Follow Up change in volume from 12 months of age scan in 24 months of age scan
Awards & highlights

Study Summary

The purpose of this research study is to learn about brain development in very young girls with Turner syndrome (TS) and the effect that growth hormone (GH) therapy has on early brain development.

Eligible Conditions
  • Turner Syndrome

Timeline

Screening ~ 3 weeks
Treatment ~ Varies
Follow Up ~change in volume from 12 months of age scan in 24 months of age scan
This trial's timeline: 3 weeks for screening, Varies for treatment, and change in volume from 12 months of age scan in 24 months of age scan for reporting.

Treatment Details

Study Objectives

Outcome measures can provide a clearer picture of what you can expect from a treatment.
Primary outcome measures
Total Brain Volume
Secondary outcome measures
Volume of Brain Lobes (Central)
Volume of Brain Lobes (Frontal)
Volume of Brain Lobes (Insular Cortex)
+5 more

Trial Design

2Treatment groups
Experimental Treatment
Active Control
Group I: Growth HormoneExperimental Treatment1 Intervention
Subjects in the somatotropin (growth hormone, GH) arm will receive GH injections from 12-24 months of life.
Group II: ControlActive Control1 Intervention
Subjects will receive no GH or placebo.
Treatment
First Studied
Drug Approval Stage
How many patients have taken this drug
Somatotropin
FDA approved

Find a Location

Who is running the clinical trial?

PfizerIndustry Sponsor
4,587 Previous Clinical Trials
14,637,845 Total Patients Enrolled
Rebecca Knickmeyer Santelli, PhDLead Sponsor
Rebecca KnickmeyerPrincipal InvestigatorUniversity of North Carolina, Chapel Hill
~1 spots leftby Jun 2025
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