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multi-modality neuroimaging for Essential Tremor

N/A
Waitlist Available
Led By Vibhor Krishna, MD SM
Research Sponsored by Vibhor Krishna
Eligibility Criteria Checklist
Specific guidelines that determine who can or cannot participate in a clinical trial
Must have
Be older than 18 years old
Timeline
Screening 3 weeks
Treatment Varies
Follow Up during the surgical procedure
Awards & highlights

Study Summary

This study is evaluating whether neuroimaging can be used to examine the functional connectivity of brain networks in Essential Tremor patients before, during, and after a focused ultrasound procedure.

Eligible Conditions
  • Essential Tremor

Timeline

Screening ~ 3 weeks
Treatment ~ Varies
Follow Up ~immediately post-operative and 24-hours after surgery for et patients
This trial's timeline: 3 weeks for screening, Varies for treatment, and immediately post-operative and 24-hours after surgery for et patients for reporting.

Treatment Details

Study Objectives

Outcome measures can provide a clearer picture of what you can expect from a treatment.
Primary outcome measures
connectivity correlates of tremor (CCT)
Secondary outcome measures
changes in functional connectivity

Trial Design

2Treatment groups
Experimental Treatment
Active Control
Group I: control cohortExperimental Treatment1 Intervention
Twenty adult healthy controls (control cohort) will undergo multi-modality neuroimaging (structural imaging, diffusion tensor imaging (DTI), task-based functional MRI (t-fMRI), and resting state functional MRI (rs-fMRI)).
Group II: ET cohortActive Control1 Intervention
Ten adults with refractory ET (ET cohort) will undergo multi-modality neuroimaging (structural imaging, diffusion tensor imaging (DTI), task-based functional MRI (t-fMRI), and resting state functional MRI (rs-fMRI)). In addition the ET cohort will also undergo imaging with the identical protocol immediately after and 24 hours after FUS-T.

Find a Location

Who is running the clinical trial?

Vibhor KrishnaLead Sponsor
3 Previous Clinical Trials
14 Total Patients Enrolled
National Institutes of Health (NIH)NIH
2,696 Previous Clinical Trials
6,952,558 Total Patients Enrolled
1 Trials studying Essential Tremor
72 Patients Enrolled for Essential Tremor
Focused Ultrasound FoundationOTHER
14 Previous Clinical Trials
274 Total Patients Enrolled

Frequently Asked Questions

These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.
Recent research and studies
clinicaltrials.govStudy
Functional Neuroimaging Feedback for Focused Ultrasound Thalamotomy
Vibhor Krishna 2018. "Functional Neuroimaging Feedback for Focused Ultrasound Thalamotomy". ClinicalTrials.gov. https://clinicaltrials.gov/ct2/show/NCT03560622.
~5 spots leftby Apr 2025
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