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Diagnostic Test

VExUS score for Sepsis (DRI-US Trial)

N/A
Waitlist Available
Led By Keith Corl, MD
Research Sponsored by The Miriam Hospital
Eligibility Criteria Checklist
Specific guidelines that determine who can or cannot participate in a clinical trial
Must have
Be older than 18 years old
Timeline
Screening 3 weeks
Treatment Varies
Follow Up 28 days and during hospital admission up to 24 weeks
Awards & highlights

DRI-US Trial Summary

This study is evaluating whether a new method of fluid resuscitation can reduce fluid overload in critically ill patients with sepsis.

Eligible Conditions
  • Volume Overload
  • Sepsis
  • Septic Shock

DRI-US Trial Timeline

Screening ~ 3 weeks
Treatment ~ Varies
Follow Up ~28 days and during hospital admission up to 24 weeks
This trial's timeline: 3 weeks for screening, Varies for treatment, and 28 days and during hospital admission up to 24 weeks for reporting.

Treatment Details

Study Objectives

Outcome measures can provide a clearer picture of what you can expect from a treatment.
Primary outcome measures
Cumulative Fluid Balance at 5 days post ICU discharge or ICU Discharge
Secondary outcome measures
28-day and in-hospital mortality
Change in SOFA score
Daily Sonographic B Line Measurement
+3 more

DRI-US Trial Design

2Treatment groups
Experimental Treatment
Active Control
Group I: VExUS-Guided ArmExperimental Treatment1 Intervention
Will receive 24 hour fluid balance target based on daily VExUS score.
Group II: Usual Care Control ArmActive Control1 Intervention
Treating team will be blinded to results of daily VExUS score and will set 24 hour fluid balance target based on usual care.

Find a Location

Who is running the clinical trial?

The Miriam HospitalLead Sponsor
238 Previous Clinical Trials
37,323 Total Patients Enrolled
Keith Corl, MDPrincipal InvestigatorRhode Island Hospital / The Miriam Hospital
1 Previous Clinical Trials
113 Total Patients Enrolled
1 Trials studying Sepsis
113 Patients Enrolled for Sepsis

Frequently Asked Questions

These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.
Recent research and studies
clinicaltrials.govStudy
De-resuscitation Informed by Ultrasound for Patients With Sepsis
2021. "De-resuscitation Informed by Ultrasound for Patients With Sepsis". ClinicalTrials.gov. https://clinicaltrials.gov/ct2/show/NCT04921319.
All > Sepsis
~39 spots leftby Apr 2025
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