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Released from hosptial prior to day 14 for Sepsis
N/A
Waitlist Available
Led By Mark Segal, M.D.
Research Sponsored by University of Florida
Eligibility Criteria Checklist
Specific guidelines that determine who can or cannot participate in a clinical trial Must have
Be older than 18 years old
Timeline
Screening 3 weeks
Treatment Varies
Follow Up 1 year
Awards & highlights
Study Summary
This trial investigates whether kidney dysfunction plays a role in worsening outcomes for patients with chronic critical illness.
Eligible Conditions
- Sepsis
Timeline
Screening ~ 3 weeks3 visits
Treatment ~ Varies
Follow Up ~ 1 year
Screening ~ 3 weeks
Treatment ~ Varies
Follow Up ~1 year
Treatment Details
Study Objectives
Outcome measures can provide a clearer picture of what you can expect from a treatment.Primary outcome measures
Area under the curve versus time curve (AUC) of Iohexol
Secondary outcome measures
Serum Creatinine
Urine Creatinine Ratio
Urine Urea Concentration
Trial Design
2Treatment groups
Experimental Treatment
Active Control
Group I: Released from hosptial prior to day 14Experimental Treatment3 Interventions
This group of sepsis participants will be released from the hospital prior to day 14. A normal saline dilution of Iohexol 0.5-1 ml will be given IV push. Blood or urine will be collected prior to the injection and at approximately 1, 2, 3, and 4 hours after the injection for glomerular filtration rate measurements. This test will be repeated in one year. In addition to or as an option would be to have a timed urine collection to determine clearance of urea and creatinine can be performed instead of the saline dilution of Iohexol 0.5-1 ml and/or an estimated of GFR using serum creatinine and cystatin C measurement using calculations from blood samples.
Group II: Inhospital group at day 14Active Control3 Interventions
This group of sepsis participants will remain hospitalized after day 14. A normal saline dilution of Iohexol 0.5-1 ml will be given IV push. Blood or urine will be collected prior to the injection and at approximately 1, 2, 3, and 4 hours after the injection for glomerular filtration rate measurements. This test will be repeated in one year. In addition to or as an option would be to have a timed urine collection to determine clearance of urea and creatinine can be performed instead of the saline dilution of Iohexol 0.5-1 ml and/or an estimated of GFR using serum creatinine and cystatin C measurement using calculations from blood samples.
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Who is running the clinical trial?
National Institutes of Health (NIH)NIH
2,696 Previous Clinical Trials
6,952,453 Total Patients Enrolled
13 Trials studying Sepsis
9,658 Patients Enrolled for Sepsis
National Institute of General Medical Sciences (NIGMS)NIH
268 Previous Clinical Trials
248,674 Total Patients Enrolled
19 Trials studying Sepsis
187,897 Patients Enrolled for Sepsis
University of FloridaLead Sponsor
1,340 Previous Clinical Trials
715,619 Total Patients Enrolled
20 Trials studying Sepsis
7,661 Patients Enrolled for Sepsis
Frequently Asked Questions
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