← Back to Search

Non-invasive Brain Stimulation

Comprehensive behavioral intervention for Tourette Syndrome (STOP-TIC Trial)

N/A
Waitlist Available
Led By Aparna Wagle Shukla, MD
Research Sponsored by University of Florida
Eligibility Criteria Checklist
Specific guidelines that determine who can or cannot participate in a clinical trial
Must have
Be older than 18 years old
Timeline
Screening 3 weeks
Treatment Varies
Follow Up baseline (t0), immediately after completion of rtms (t1), immediately after completion of cbit (t2), and approximately one month after completion of the intervention (rtms + cbit) (t3)
Awards & highlights

STOP-TIC Trial Summary

This study is evaluating whether rTMS can improve tics in people with Tourette's Syndrome.

Eligible Conditions
  • Tourette Syndrome

STOP-TIC Trial Timeline

Screening ~ 3 weeks
Treatment ~ Varies
Follow Up ~baseline (t0), immediately after completion of rtms (t1), immediately after completion of cbit (t2), and approximately one month after completion of the intervention (rtms + cbit) (t3)
This trial's timeline: 3 weeks for screening, Varies for treatment, and baseline (t0), immediately after completion of rtms (t1), immediately after completion of cbit (t2), and approximately one month after completion of the intervention (rtms + cbit) (t3) for reporting.

Treatment Details

Study Objectives

Outcome measures can provide a clearer picture of what you can expect from a treatment.
Primary outcome measures
Tic Severity
Secondary outcome measures
Adult ADHD Self-Report Scale (ASRS)
Anxiety
Beck Depression Inventory (BDI)
+4 more

STOP-TIC Trial Design

1Treatment groups
Experimental Treatment
Group I: Active rTMS GroupExperimental Treatment2 Interventions
Patients will be seated in a comfortable reclined chair. The neurostimulation protocol will include 1-Hz rTMS over the bilateral SMA at 110% resting motor threshold (RMT). The SMA will be identified as 4 cm anterior to the vertex (Cz in standard 10-20 EEG setup). Each session will consist of 6 trains lasting 5 minutes each (300 pulses per train) with an intertrain interval of 1 minute for a total duration of 35 minutes (1800 pulses). Patients will receive 4 sessions each day on 4 consecutive days for a total of 16 sessions. Daily duration of this study protocol should last approximately 170 minutes including a 10 minute break in between each session.
Treatment
First Studied
Drug Approval Stage
How many patients have taken this drug
Transcranial Magnetic Stimulation
2017
Completed Phase 4
~730
Comprehensive behavioral intervention
2021
N/A
~10

Find a Location

Who is running the clinical trial?

University of FloridaLead Sponsor
1,341 Previous Clinical Trials
715,664 Total Patients Enrolled
7 Trials studying Tourette Syndrome
139 Patients Enrolled for Tourette Syndrome
Aparna Wagle Shukla, MDPrincipal InvestigatorUniversity of Florida
4 Previous Clinical Trials
105 Total Patients Enrolled
Jessica Frey, MDPrincipal InvestigatorUniversity of Florida
2 Previous Clinical Trials
25 Total Patients Enrolled
1 Trials studying Tourette Syndrome
20 Patients Enrolled for Tourette Syndrome

Frequently Asked Questions

These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.
Recent research and studies
clinicaltrials.govStudy
Combined CBIT and rTMS to Improve Tourette's Syndrome
2021. "Combined CBIT and rTMS to Improve Tourette's Syndrome". ClinicalTrials.gov. https://clinicaltrials.gov/ct2/show/NCT04795908.
~1 spots leftby Apr 2025
Unbiased ResultsWe believe in providing patients with all the options.
Your Data Stays Your DataWe only share your information with the clinical trials you're trying to access.
Verified Trials OnlyAll of our trials are run by licensed doctors, researchers, and healthcare companies.
Back to top