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Behavioural Intervention

Real TBS to the vmPFC for Smoking

N/A
Waitlist Available
Led By Merideth A. Addicott, PhD
Research Sponsored by Wake Forest University Health Sciences
Eligibility Criteria Checklist
Specific guidelines that determine who can or cannot participate in a clinical trial
Must have
Be older than 18 years old
Timeline
Screening 3 weeks
Treatment Varies
Follow Up through study completion, an average of 8 weeks
Awards & highlights

Study Summary

This trial is looking at using magnetic stimulation to help people quit smoking, specifically in the first week after they quit, when cravings are highest.

Eligible Conditions
  • Addiction
  • Smoking
  • Nicotine Addiction
  • Smoking/Cigarette Smoking
  • Craving
  • Smoking Cessation

Timeline

Screening ~ 3 weeks
Treatment ~ Varies
Follow Up ~through study completion, an average of 8 weeks
This trial's timeline: 3 weeks for screening, Varies for treatment, and through study completion, an average of 8 weeks for reporting.

Treatment Details

Study Objectives

Outcome measures can provide a clearer picture of what you can expect from a treatment.
Primary outcome measures
Questionnaire on Smoking Urges administered daily both pre/post TMS to measure craving
Self- report assessment of tobacco use through Timeline Follow-Back (TLFB) Interview
Secondary outcome measures
Biochemical assessment of recent tobacco use via breath Carbon Monoxide (CO) sample
Biochemical assessment of tobacco use via quantitative urine screens to detect cotenine level
Changes in Delayed Discounting Cognitive Behavioral Task
+2 more

Trial Design

4Treatment groups
Experimental Treatment
Placebo Group
Group I: Real TBS to the vmPFCExperimental Treatment1 Intervention
Ten sessions of real Theta Burst Stimulation (TBS) will be delivered to the left medial prefrontal cortex (mPFC)
Group II: Real TBS to the dlPFCExperimental Treatment1 Intervention
Ten sessions of real intermittent Theta Burst Stimulation (TBS) will be delivered to the left dorsolateral prefrontal cortex (dlPFC)
Group III: Sham TBS to the dlPFCPlacebo Group1 Intervention
Ten sessions of sham Theta Burst Stimulation (iTBS) will be delivered to the left dorsolateral prefrontal cortex (dlPFC)
Group IV: Sham TBS to the vmPFCPlacebo Group1 Intervention
Ten sessions of sham Theta Burst Stimulation (TBS) will be delivered to the left medial prefrontal cortex (mPFC)
Treatment
First Studied
Drug Approval Stage
How many patients have taken this drug
Real TBS to the dlPFC
2020
N/A
~70
Real TBS to the vmPFC
2020
N/A
~70

Find a Location

Who is running the clinical trial?

Wake Forest University Health SciencesLead Sponsor
1,240 Previous Clinical Trials
1,004,142 Total Patients Enrolled
3 Trials studying Smoking
956 Patients Enrolled for Smoking
Virginia Tech Carilion School of Medicine and Research InstituteOTHER
6 Previous Clinical Trials
2,493 Total Patients Enrolled
Merideth A. Addicott, PhDPrincipal InvestigatorWake Forest University Health Sciences

Frequently Asked Questions

These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.

Who else is applying?

What state do they live in?
Wisconsin
How old are they?
18 - 65
What portion of applicants met pre-screening criteria?
Did not meet criteria
Recent research and studies
clinicaltrials.govStudy
QuitFast: Evaluating Transcranial Magnetic Stimulation as a Tool to Reduce Smoking Directly Following a Quit Attempt
2020. "QuitFast: Evaluating Transcranial Magnetic Stimulation as a Tool to Reduce Smoking Directly Following a Quit Attempt". ClinicalTrials.gov. https://clinicaltrials.gov/ct2/show/NCT04159571.
~14 spots leftby Apr 2025
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