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Behavioural Intervention

Transcranial Magnetic Stimulation for Smoking Addiction

N/A
Recruiting
Led By Nicole Petersen, Ph.D
Research Sponsored by University of California, Los Angeles
Eligibility Criteria Checklist
Specific guidelines that determine who can or cannot participate in a clinical trial
Must have
Be between 18 and 65 years old
Timeline
Screening 3 weeks
Treatment Varies
Follow Up 4 weeks
Awards & highlights

Study Summary

This trial is testing if transcranial magnetic stimulation can help smokers quit by stimulating different parts of the brain. There will be a sham procedure to control for placebo effects.

Who is the study for?
This trial is for individuals aged 18-45 with Tobacco Use Disorder who smoke at least 10 cigarettes daily and have done so for over a year. Participants must be in good health without major diseases or psychiatric disorders, not use other tobacco forms frequently, and not be pregnant or seeking nicotine dependence treatment.Check my eligibility
What is being tested?
The study tests if rTMS can reduce cigarette cravings and withdrawal symptoms. It involves four sessions targeting different brain areas at UCLA, with each session followed by an MRI scan and questionnaires. Men's and women's responses to the treatment are compared.See study design
What are the potential side effects?
rTMS is generally considered safe but may cause discomfort at the stimulation site, headache, lightheadedness, or seizures in very rare cases. The MRI might cause discomfort due to its enclosed nature.

Timeline

Screening ~ 3 weeks
Treatment ~ Varies
Follow Up ~4 weeks
This trial's timeline: 3 weeks for screening, Varies for treatment, and 4 weeks for reporting.

Treatment Details

Study Objectives

Outcome measures can provide a clearer picture of what you can expect from a treatment.
Primary outcome measures
Positive and Negative Affect Schedule (PANAS)
Repetitive Transcranial Magnetic Stimulation (rTMS)
Shiffman-Jarvik Withdrawal Scale
+1 more
Secondary outcome measures
Baseline Magnetic Resonance Imaging (MRI)
Post-stimulation Magnetic Resonance Imaging (MRI)

Side effects data

From 2005 Phase 2 trial • 50 Patients • NCT00004980
59%
Headache
100%
80%
60%
40%
20%
0%
Study treatment Arm
Active Repetitive Transcanial Magnetic Stimulation
Placebo

Trial Design

4Treatment groups
Experimental Treatment
Placebo Group
Group I: TMS on dlPFCExperimental Treatment1 Intervention
Device: repetitive transcranial magnetic stimulation (rTMS) Transcranial magnetic stimulation (TMS) uses magnetic stimulation to change patterns of activity in your brain. This arm will target the dorsolateral prefrontal cortex (dlPFC). Other Name: rTMS (active stimulation)
Group II: TMS on SFGExperimental Treatment1 Intervention
Device: repetitive transcranial magnetic stimulation (real) Transcranial magnetic stimulation (TMS) uses magnetic stimulation to change patterns of activity in your brain. This arm will target the superior frontal gyrus (SFG). Other Name: rTMS (active stimulation)
Group III: TMS on PPCExperimental Treatment1 Intervention
Device: repetitive transcranial magnetic stimulation (rTMS) Transcranial magnetic stimulation (TMS) uses magnetic stimulation to change patterns of activity in your brain. This arm will target the posterior parietal cortex (PPC). Other Name: rTMS (active stimulation)
Group IV: TMS on v5Placebo Group1 Intervention
Device: repetitive transcranial magnetic stimulation (rTMS) Transcranial magnetic stimulation (TMS) uses magnetic stimulation to change patterns of activity in your brain. This arm will target visual cortex (v5). Other Name: rTMS (sham stimulation)
Treatment
First Studied
Drug Approval Stage
How many patients have taken this drug
repetitive transcranial magnetic stimulation (rTMS)
2003
Completed Phase 2
~380

Find a Location

Who is running the clinical trial?

University of California, Los AngelesLead Sponsor
1,530 Previous Clinical Trials
10,278,142 Total Patients Enrolled
8 Trials studying Tobacco Use Disorder
958 Patients Enrolled for Tobacco Use Disorder
National Institutes of Health (NIH)NIH
2,697 Previous Clinical Trials
7,492,259 Total Patients Enrolled
45 Trials studying Tobacco Use Disorder
26,160 Patients Enrolled for Tobacco Use Disorder
National Institute on Drug Abuse (NIDA)NIH
2,468 Previous Clinical Trials
2,619,288 Total Patients Enrolled
271 Trials studying Tobacco Use Disorder
49,007 Patients Enrolled for Tobacco Use Disorder

Media Library

repetitive transcranial magnetic stimulation (rTMS) (Behavioural Intervention) Clinical Trial Eligibility Overview. Trial Name: NCT03827265 — N/A
Tobacco Use Disorder Research Study Groups: TMS on v5, TMS on SFG, TMS on PPC, TMS on dlPFC
Tobacco Use Disorder Clinical Trial 2023: repetitive transcranial magnetic stimulation (rTMS) Highlights & Side Effects. Trial Name: NCT03827265 — N/A
repetitive transcranial magnetic stimulation (rTMS) (Behavioural Intervention) 2023 Treatment Timeline for Medical Study. Trial Name: NCT03827265 — N/A

Frequently Asked Questions

These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.

How many applicants are being considered for participation in this clinical experiment?

"Affirmative. Clinicaltrials.gov displays that this clinical trial, which had its first post on February 1st 2019, is still in demand of applicants. A total of 60 patients are currently needed at a single medical centre."

Answered by AI

Who is qualified to participate in this research experiment?

"This research project is recruiting 60 individuals with nicotine addiction between ages 18 and 45. For admission, applicants need to fulfil the following criteria: age range of 18-45 years, gender identification as male or female, absence of cardiovascular issues, hepatic problems, renal conditions or autoimmune diseases; no diabetes diagnosis nor cancer history; at least one year smoking cigarettes daily (10 minimum)."

Answered by AI

What are the study's primary objectives?

"This clinical trial is conducted over a 4 week period and its primary outcome will be measured with the Urge to Smoke Questionnaire. Secondary outcomes are observed by Post-stimulation MRI, Baseline Magnetic Resonance Imaging (MRI), and Post-stimulation Magnetic Resonance Imaging (MRI)."

Answered by AI

Is there availability for participants in this experiment?

"Affirmative. According to the data on clinicaltrials.gov, this medical examination is currently enrolling patients and has been since February 1st 2019. The most recent update was performed on November 9th 2021 and it requires 60 participants from a single site for completion."

Answered by AI

Does the eligibility criteria for this research endeavor include seniors aged 70 or above?

"Patients of legal age (18-45) are eligible to enroll in this trial. Alternatively, there are 4 trials available for those under 18 and 76 studies accommodating seniors over the age of 65."

Answered by AI
~10 spots leftby Apr 2025