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Gene Expression for Compartment Syndrome

N/A

Waitlist Available

Led By Justin Haller, M.D.

Research Sponsored by University of Utah

Eligibility Criteria Checklist

Specific guidelines that determine who can or cannot participate in a clinical trial

Must have

Patients with the clinical diagnosis of exertional compartment syndrome with planned surgical intervention.

Patients without clinical compartment syndrome undergoing operative intervention within 48 hours of injury for tibial shaft or tibial plateau fractures.

Timeline

Screening 3 weeks

Treatment Varies

Follow Up immediately after the muscle tissue harvest procedure.

Awards & highlights

Study Summary

This trial looks at whether there are genetic differences between people who develop a condition called acute traumatic compartment syndrome (ATCS) and those who don't, as well as whether there are differences in how the genes are expressed.

Who is the study for?

This trial is for English-speaking adults over 18 with lower leg injuries at risk of compartment syndrome. It includes those planning surgery for exertional compartment syndrome and patients with acute compartment syndrome from tibial fractures, as well as a control group without the syndrome.Check my eligibility

What is being tested?

The study aims to identify genetic differences by comparing gene expression in patients who develop acute traumatic compartment syndrome after a lower extremity injury to those who don't but have similar at-risk fractures.See study design

What are the potential side effects?

Since this trial focuses on observing genetic expressions rather than testing medications or interventions, there are no direct side effects associated with the study itself.

Eligibility Criteria

Inclusion Criteria

You may be eligible if you check “Yes” for the criteria below

Select...

I am diagnosed with exertional compartment syndrome and scheduled for surgery.

Select...

I am having surgery within 2 days for a broken shinbone without severe swelling.

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I have acute compartment syndrome in my lower leg due to a tibia fracture.

Timeline

Screening ~ 3 weeks3 visits

Treatment ~ Varies

Follow Up ~ immediately after the muscle tissue harvest procedure.

Screening ~ 3 weeks

Treatment ~ Varies

Follow Up ~immediately after the muscle tissue harvest procedure.

This trial's timeline: 3 weeks for screening, Varies for treatment, and immediately after the muscle tissue harvest procedure. for reporting.

Treatment Details

Study Objectives

Outcome measures can provide a clearer picture of what you can expect from a treatment.

Primary outcome measures

Myostatin (% increase)

Trial Design

3Treatment groups

Experimental Treatment

Group I: Exertional compartment syndromeExperimental Treatment1 Intervention

Patients with a diagnosis of exertional compartment syndrome who are planning to undergo surgical procedure to release the compartment fascia will be recruited to participate prior to surgical intervention.

Group II: Acute tibial shaft or tibial plateau fractures without compartment syndromeExperimental Treatment1 Intervention

Patients with acute lower leg fractures who do not have clinical compartment syndrome.

Group III: Acute tibial shaft or tibial plateau fractures with compartment syndrome.Experimental Treatment1 Intervention

Patients with acute lower leg fractures with acute compartment syndrome.

0 / 3Eligibility criteria met

Find a Location

Who is running the clinical trial?

University of UtahLead Sponsor

1,098 Previous Clinical Trials

1,778,550 Total Patients Enrolled

Justin Haller, M.D.Principal InvestigatorUniversity of Utah Orthopaedics

2 Previous Clinical Trials

100 Total Patients Enrolled

Media Library

Acute injury with compartment syndrome Clinical Trial Eligibility Overview. Trial Name: NCT05521958 — N/A

$Tibial Shaft Fracture Research Study Groups: Acute tibial shaft or tibial plateau fractures with compartment syndrome., Exertional compartment syndrome, Acute tibial shaft or tibial plateau fractures without compartment syndrome$

Tibial Shaft Fracture Clinical Trial 2023: Acute injury with compartment syndrome Highlights & Side Effects. Trial Name: NCT05521958 — N/A

Acute injury with compartment syndrome 2023 Treatment Timeline for Medical Study. Trial Name: NCT05521958 — N/A

Frequently Asked Questions

These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.

Does this research endeavor still have available spots for participants?

"According to clinicaltrials.gov, the posted requirements for this trial have not been updated since August 25th 2022 and are currently closed to prospective participants. Although no longer recruiting patients, there remain 1,741 other medical studies that are looking for volunteers at present."

Answered by AI

Are my qualifications sufficient to enter this medical trial?

"This clinical trial is seeking 80 individuals aged 18 to 90 with fractures. In addition, they must be proficient in English and meet any of the following criteria: i) Patient over 18 undergoing surgery for tibial shaft or plateau fracture within 48 hours; ii) Patients diagnosed with exertional compartment syndrome requiring surgical intervention; iii) Individuals suffering from lower leg acute compartment syndrome due to a tibial fracture."

Answered by AI

Does this research study allow for patients aged 70 or older to enroll?

"Patients aged between 18 and 90 years old can join this medical trial. For those under the age of 18, there are 445 different options available, while 1277 trials exist for adults over 65."

Answered by AI

Recent research and studies

clinicaltrials.govStudy

Gene Expression in Lower Extremity Acute Traumatic Compartment Syndrome

Justin Haller 2022. "Gene Expression in Lower Extremity Acute Traumatic Compartment Syndrome". ClinicalTrials.gov. https://clinicaltrials.gov/ct2/show/NCT05521958.