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Biological

Platelet Rich Plasma plus IGF for Tendinopathy

N/A
Waitlist Available
Led By Michael Baria, MD
Research Sponsored by Ohio State University
Eligibility Criteria Checklist
Specific guidelines that determine who can or cannot participate in a clinical trial
Must have
Be older than 18 years old
Timeline
Screening 3 weeks
Treatment Varies
Follow Up 6 months
Awards & highlights

Study Summary

This trial is comparing two different PRP injections for patellar tendinosis, to see which is more effective.

Eligible Conditions
  • Tendinopathy
  • Patellar Tendon
  • Platelet Rich Plasma

Timeline

Screening ~ 3 weeks
Treatment ~ Varies
Follow Up ~6 months
This trial's timeline: 3 weeks for screening, Varies for treatment, and 6 months for reporting.

Treatment Details

Study Objectives

Outcome measures can provide a clearer picture of what you can expect from a treatment.
Primary outcome measures
Victorian Institute of Sport Assessment-patellar Tendon (VISA-P)
Secondary outcome measures
Blazina Classification
Tegner Activity Scale
Visual Analog Scale-Pain

Trial Design

2Treatment groups
Active Control
Group I: Platelet Rich Plasma plus IGFActive Control1 Intervention
The PRP preparation and blood draw will be identical to the above. 55ml of whole blood will be drawn (1ml will undergo a CBC and the remaining 54ml will be used to make PRP). In addition to preparing the PRP, the resultant PPP (instead of discarding it) will be placed into the Plasmax device (Zimmer Biomet, Warsaw, IN) and concentrated via a second centrifugation cycle. The plasmax concentrate (concentrated IGF) will be added to the PRP (3ml of PRP + 2ml of plasmax concentrate for a total of 5ml) and then will be injected (after 5ml 1% lidocaine has been injected into the skin for comfort) under ultrasound guidance followed by the same rest period.
Group II: Platelet Rich PlasmaActive Control1 Intervention
Procedure will be carried out with excellent sterile technique. 54ml of whole blood will be drawn. 54ml will be processed by centrifugation using the GPS III system (Zimmer Biomet, Warsaw, IN) and 1 ml will undergo a complete blood count (for a baseline comparison to determine the fold increase in platelets). The resultant PRP (5ml) will be injected (after 5ml 1% lidocaine has been injected into the skin for comfort) into the patellar tendon using ultrasound guidance to accurately direct the injection to the site of the tendon abnormality. The patient will rest after the injection for 15 minutes and then be dismissed.

Find a Location

Who is running the clinical trial?

Ohio State UniversityLead Sponsor
829 Previous Clinical Trials
505,729 Total Patients Enrolled
Michael Baria, MDPrincipal Investigator - Ohio State University
OSU Harding Hospital, Ohio State University Hospital - Wexner Medical Center, Richard M. Ross Heart Hospital
Wright State University School Of Medicine (Medical School)
1 Previous Clinical Trials
79 Total Patients Enrolled

Frequently Asked Questions

These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.
Recent research and studies
The American Journal of Sports MedicineJournal
Hyaluronic Acid Versus Platelet-rich Plasma: A Prospective, Double-blind Randomized Controlled Trial Comparing Clinical Outcomes and Effects on Intra-articular Biology for the Treatment of Knee Osteoarthritis
Cole, Brian J., Vasili Karas, Kristen Hussey, David B. Merkow, Kyle Pilz, and Lisa A. Fortier. 2016. “Hyaluronic Acid Versus Platelet-rich Plasma: A Prospective, Double-blind Randomized Controlled Trial Comparing Clinical Outcomes and Effects on Intra-articular Biology for the Treatment of Knee Osteoarthritis”. The American Journal of Sports Medicine. SAGE Publications. doi:10.1177/0363546516665809.
The American Journal of Sports MedicineJournal
Intra-articular Autologous Conditioned Plasma Injections Provide Safe and Efficacious Treatment for Knee Osteoarthritis
Smith, Patrick A.. 2016. “Intra-articular Autologous Conditioned Plasma Injections Provide Safe and Efficacious Treatment for Knee Osteoarthritis”. The American Journal of Sports Medicine. SAGE Publications. doi:10.1177/0363546515624678.
The American Journal of Sports MedicineJournal
Treatment with Platelet-rich Plasma Is More Effective Than Placebo for Knee Osteoarthritis
Patel, Sandeep, Mandeep S. Dhillon, Sameer Aggarwal, Neelam Marwaha, and Ashish Jain. 2013. “Treatment with Platelet-rich Plasma Is More Effective Than Placebo for Knee Osteoarthritis”. The American Journal of Sports Medicine. SAGE Publications. doi:10.1177/0363546512471299.
The American Journal of Sports MedicineJournal
Hyaluronic Acid Versus Platelet-rich Plasma: A Prospective, Double-blind Randomized Controlled Trial Comparing Clinical Outcomes and Effects on Intra-articular Biology for the Treatment of Knee Osteoarthritis
Cole, Brian J., Vasili Karas, Kristen Hussey, David B. Merkow, Kyle Pilz, and Lisa A. Fortier. 2016. “Hyaluronic Acid Versus Platelet-rich Plasma: A Prospective, Double-blind Randomized Controlled Trial Comparing Clinical Outcomes and Effects on Intra-articular Biology for the Treatment of Knee Osteoarthritis”. The American Journal of Sports Medicine. SAGE Publications. doi:10.1177/0363546516665809.
~3 spots leftby Apr 2025
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