Study Summary
This trial demonstrates that STAR ablation is a safe and feasible option for cardiomyopathy patients with refractory ventricular tachycardia.
Eligible Conditions
- Stereotactic Radioablation for Ventricular Tachycardia
Treatment Effectiveness
Effectiveness Progress
Study Objectives
2 Primary · 1 Secondary · Reporting Duration: 6 month period before treatment to the 6 month period after ablation with a 6 week blanking period post-treatment.
Month 6
Efficacy of radiation treatment for VT reduction
90 days after treatment
Safety composite endpoint of radiation treatment-related pericarditis, pneumonitis, changes in cardiac structures, function, and/or ICD function.
Six months
Overall mortality
Trial Safety
Safety Progress
Trial Design
1 Treatment Group
Radioablation Treatment
1 of 1
Experimental Treatment
20 Total Participants · 1 Treatment Group
Primary Treatment: Stereotactic Radioablation · No Placebo Group · N/A
Radioablation Treatment
Radiation
Experimental Group · 1 Intervention: Stereotactic Radioablation · Intervention Types: RadiationTrial Logistics
Trial Timeline
Screening: ~3 weeks
Treatment: Varies
Reporting: 6 month period before treatment to the 6 month period after ablation with a 6 week blanking period post-treatment.
Who is running the clinical trial?
University of CalgaryLead Sponsor
706 Previous Clinical Trials
493,701 Total Patients Enrolled
Libin Cardiovascular Institute of AlbertaOTHER
3 Previous Clinical Trials
628 Total Patients Enrolled
Vikas Kuriachan, MDPrincipal InvestigatorUniversity of Calgary
Eligibility Criteria
Age 18+ · All Participants · 3 Total Inclusion Criteria
Mark “Yes” if the following statements are true for you:References
- “Noninvasive Ablation of Ventricular Tachycardia”. 2018. “Noninvasive Ablation of Ventricular Tachycardia”. New England Journal of Medicine. Massachusetts Medical Society. doi:10.1056/nejmc1802625.
- Cuculich, Phillip S., Matthew R. Schill, Rojano Kashani, Sasa Mutic, Adam Lang, Daniel Cooper, Mitchell Faddis, et al.. 2017. “Noninvasive Cardiac Radiation for Ablation of Ventricular Tachycardia”. New England Journal of Medicine. Massachusetts Medical Society. doi:10.1056/nejmoa1613773.
- Cuculich PS, Robinson CG. Noninvasive Ablation of Ventricular Tachycardia. N Engl J Med. 2018 Apr 26;378(17):1651-1652. doi: 10.1056/NEJMc1802625. No abstract available.
- Vikas Kuriachan 2021. "Stereotactic Arrhythmia Radioablation for Ventricular Tachycardia Management". ClinicalTrials.gov. https://clinicaltrials.gov/ct2/show/NCT04065802.
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Conditions
Cancer Related
Treatments